Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"tip links"”.
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Light Stimulation of Sensory Hair Cells
… force-sensitive ion channels by the tension in tip links located at the tops of the stereocilia. The study of hair cells and their mechanically gated channels has heretofore required physical displacement of a hair bundle to open its mechanotransduction channels. The work presented here …
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The Role of the Stereociliary Glycocalyx in Hair Bundle Cohesion
… channels joined to proteinaceous tip links that connect the distal tips of neighboring stereocilia along the axis of mechanosensitivity. When the hair bundle is deflected and the distal tips of stereocilia shear in relation to one another, tension is applied to the tip links …
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Modeling the Stimulation of Vestibular Hair Cell Bundles Using Computational Fluid Dynamics and Finite Element Analysis
… of hair cell bundles were modeled using tip-forcing only (commonly used experimentally), fluid-flow only (physiologic for free-standing bundles), and combined loading (physiologic for bundles with tip attachments) conditions to determine how the bundles behaved in each case. The bundles …
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Tension Propagation Along Tip-Link Cadherins: Regulation and Implications for the Auditory System
… atop the stereocilia and are gated by tension in tip links. Experimental evidence and theoretical arguments implicate a soft compliant element, with a stiffness of 1-4 mN/m, as necessary for mechanotransduction. Although the identity of this element remains an open question, direct measurements of …
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Analysis of Vestibular Hair Cell Bundle Mechanics Using Finite Element Modeling
… point load was analyzed. Bundle stiffness and tip link tension distributions were the primary data examined. The cells fell into two groups based on stiffness. All cells exhibited an increase in stiffness as the applied load was increased, but cells in the stiffer group showed a greater …
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The Nanomechanics of Protocadherin 15, A Protein Essential for Human Hearing
… but a leading candidate is the filamentous tip link connecting the mechanotransduction channel to the tallest neighboring stereocilium. The tip link is essential to mechanotransduction: when it is broken, mechanotransduction is abolished, and when it is allowed to regenerate, …