Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"time-kill curves"”.
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Cell physiology based pharmacodynamic modeling of antimicrobial drug combinations
… The population growth data comprised extensive time-kill curves for clinically relevant antibiotics (tetracycline, chloramphenicol, vancomycin, meropenem, linezolid, including dual combinations). The new cell-level approach allowed for the first time to simultaneously describe single and …
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A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents
… multiple doses of INH mimicking concentration-time profiles encountered during multiple dosing <em>in vivo</em>. The time-kill data was analyzed using a semi-mechanistic PK/PD model that included an adaptive IC50 function for explaining the re-growth of bacteria observed over the course of …