Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"tight junctions"”.
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MOLECULAR PHYSIOLOGY OF BLOOD-BRAIN BARRIER TIGHT JUNCTIONS
… of the BBB see from the perspective of its tight junctions (TJ). Tight junctions are a protein-protein adhesion structures that seal the paracellular space for small solutes. Tight junctions are a common feature in many epithelial and endothelial tissues and a crucial component of the BBB. …
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Role of Occludin in the Regulation of Epithelial Tight Junctions
<p>Tight junctions (TJ) constitute the primary component of epithelial barrier function, a disruption of which is involved in the pathogenesis of many gastrointestinal, pulmonary and renal diseases. Occludin is the major transmembrane protein of TJ, a deletion of which leads to a complex phenotype …
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Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx
… prevalence of dry eye disease. Impairment of tight junctions and glycocalyx, which are critical for ocular surface barrier function, may underlie these diabetes-associated ocular surface defects. Therefore, the present study was designed to investigate the effect of high glucose exposure and …
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Role of Protein Kinase C Zeta (PKCζ) in Regulation of Epithelial Tight Junctions
… on Ser and Thr residues in intact epithelial tight junctions. The dynamics of epithelial tight junctions appear to involve reversible phosphorylation of occludin on Ser and Thr residues. In the present study we determined the role of PKCζ in occludin phosphorylation and the dynamics of tight …
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Role of Extracellular Signal-Regulated Kinase (ERK) in Regulation of Intestinal Epithelial Tight Junctions
… (ERK1/2) is involved in regulation of epithelial tight junctions. There are different opinions expressed by investigators as to whether ERK disrupts the junctions or protects them. ERK has also been demonstrated to mediate the EGF-caused protection of the intestinal epithelial tight junctions (TJ) …
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Asthma: Cytokine-Induced Over-Expression of Matrix Metalloproteases Compromises Airway Epithelium Tight Junctions and a Clinical Case Study
… of the molecular cause of asthma is that the tight junctions of the airway epithelium are disrupted as a result of cytokine activity that up regulates expression of matrix metalloprotease 9. MMP9 encourages detachment-induced cell death - anoikis - which results in a structural change …
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Modulation of Brain Tissue Transport and Endothelial Glycocalyx and Tight Junctions of the Blood-Brain Barrier by Transcranial Direct Current Stimulation
… disrupt the endothelial glycocalyx (EG) and tight junctions of the BBB. The second part of the dissertation aimed to confirm this prediction indirectly in vivo by quantifying the BBB permeability to solutes with the same size but carrying opposite charges under control and after tDCS …
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Η μελέτη της επίδρασης του οξειδωτικού στρες στην οκλουδίνη, βασικού δομικού μορίου των στενών δεσμών (tight junctions) του αιματοεγκεφαλικού φραγμού σε επίμυες. Μελέτη της πιθανής προφυλακτικής επίδρασης αντιοξειδωτικών παραγόντων
Ο αιματο-εγκεφαλικός φραγμός (ΑΕΦ) παίζει έναν καθοριστικό ρόλο στην ομοιόσταση του Κεντρικού Νευρικού Συστήματος. Οι στενοσύνδεσμοι (TJ) των ενδοθηλιακών κυττάρων των εγκεφαλικών τριχοειδών συνεισφέρουν σημαντικά στη λειτουργία του ΑΕΦ περιορίζοντας την παρακυτταρική διάχυση. Η οκλουδίνη, μια …
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Computational Algorithms for Predicting Membrane Protein Assembly From Angstrom to Micron Scale
… of epithelial and endothelial cells called tight junctions with high molecular specificities are vital for homeostasis and to maintain proper health. While the breakdown of these barriers is associated with serious pathological consequences, their intact presence also poses a challenge to …
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Computational Algorithms For Predicting Membrane Protein Assembly From Angstrom To Micron Scale
… of epithelial and endothelial cells called tight junctions with high molecular specificities are vital for homeostasis and to maintain proper health. While the breakdown of these barriers is associated with serious pathological consequences, their intact presence also poses a challenge to …
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Neural Circuitry Deficits Associated With Dysfunctional Myelin
… mutant mice that lack Claudin 11 (Cldn11) tight junctions in CNS myelin sheaths. In myelin sheaths, Cldn11 forms tight junctions located along the outer and inner edges of the membrane spiral, preventing ions and small molecules from entering the intramyelinic space. The function of Cldn11 …
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Intestinal Inflammation Model Inducing Gut Leakage by Different Methods in Broiler Chickens Using FITC-d as a Marker
… passage into blood can be used as a marker for tight junction permeability. FITC-d is a large molecule (3-5 kDa) which does not usually leak through the intact gastrointestinal tract barrier. However, when conditions disrupt the tight junctions between epithelial cells, the FITC-d molecule can …
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Placental co-culture model reveals Listeria monocytogenes utilization of monocytes for vertical transmission
… integrity was confirmed using immunostaining of tight junctions and a FITC-dextran permeability assay. The model was then used to observe L. monocytogenes use of the “Trojan horse” method for vertical transmission. Human monocyte THP-1 cells were exposed to L. monocytogenes (MOI 100) for one hour …
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Mechanisms of methylenedianiline toxicity to rat biliary epithelial cells
… glucose, suggesting that DAPM loosens hepatic tight junctions. Early ultrastructural alterations in BEC mitochondria, however, suggested a possible role of mitochondrial dysfunction in the ability of BEC to maintain glucose transport and tight junction integrity. The working hypothesis for this …
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Development of Quantitative Tools for the Characterization and Analysis of the Blood Brain Barrier in Normal and MPS IIIB Mice
… cerebral endothelial cells known as the tight junctions (TJs) and the relationship of other supporting cells and proteins such as astrocytes, pericytes, microglia, and the basement membrane and extracellular matrix proteins associated with the endothelial cells. While beneficial in …
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Chloride Channels in Normal Human Blood Monocytes and a Macrophage-like Cell Line
… to, and actively migrate through, endothelial tight junctions in order to enter tissue, where they then differentiate into macrophages and function to phagocytose apoptotic bodies and damaged cells. Migration of monocytes into tissues through endothelial tight junctions requires shape and …
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Neurotoxic effects of malathion and lead acetate on the blood-brain barrier: Disruptive effects caused by different mechanisms examined with an in vitro blood-brain barrier system
… The main feature of the BBB is the presence of tight junctions between cells, which provide the BBB with its low permeability. The work presented in this dissertation tests the hypothesis that lead and malathion disrupt BBB integrity by affecting tight junctions of the BBB. The hypothesis …
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Activated EphA4 receptor in <i>Xenopus laevis</i> acts rhrough src- like tyrosine kinase p59fyn to inhibit RhoA GTPase
… laevis</em>, causes loss of cell adhesion, tight junctions, and stress fibers. Previous studies revealed that these receptors achieve their cellular effects at least in part by inhibiting RhoA GTPase. However, what links these GTPases with the EphA4 receptor remained unknown.</p> <p>In an …
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