Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"tight junction proteins"”.
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Charakterisierung der Funktion des Tight Junction Proteins hu-CLDN1 und seine Bedeutung bei der Tumorgenese
… wurden erstmals die wahrscheinlich wichtigsten Tight Junction Proteine, Claudin-1 und -2 in der Maus beschrieben. An Hand von Sequenzhomologien konnten bis heute dieser 4 Transmembrandomänen Proteinfamilie 18 Mitglieder mit unterschiedlichen Gewebeverteilungen zugeordnet werden. Parallel zum …
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Colonic metabolism of dietary grape seed extract: Analytical method development, effect on tight-junction proteins, tissue accumulation, and pan-colonic pharmacokinetics
… seed extract increased the expression of gut junction protein occludin and reduced levels of fecal calprotectin, which suggests an improvement of gut barrier integrity and a potential modulation of endotoxemia. Additionally, chronic supplementation of the diet with flavanols did not increase …
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Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx
… prevalence of dry eye disease. Impairment of tight junctions and glycocalyx, which are critical for ocular surface barrier function, may underlie these diabetes-associated ocular surface defects. Therefore, the present study was designed to investigate the effect of high glucose exposure and …
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Effect of probiotics or high incubation temperature on gene expression and cell organization of the small intestine and yolk sac of chicks
… structure of epithelial cell-lined villi with tight junctions between adjacent cells. Probiotics have been reported to improve chicken growth performance and gut health including promotion of intestinal morphology. However, there are few studies that show the effect of probiotics on ontogeny of …
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Do Probiotics Protect Against the Deleterious Effects of a High-Fat Diet?
… metabolic dysregulation and degradation of tight-junction proteins between intestinal cells. Probiotic supplementation is the practice of ingesting live strains of bacteria that are proposed to have a beneficial effect on the host by enriching the intestine with healthy bacteria. The purpose …
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The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier
… addition, they inhibited the immunoreactivity of tight junction proteins (TJs; ZO-1 (Zonula occludens-1) and claudin-5). In in vitro model, pre-treatment of OE, Quer, YE, and HSP significantly attenuated hypoxia-induced Blood-Brain Barrier (BBB) hyperpermeability. The four materials also inhibited …
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Zebrafish Posterior Lateral Line Organogenesis Regulation by Notch Signaling
… that Notch signaling induces cell adhesion and tight junction proteins that interact with cytoskeleton causing cells to self‐organize into fewer larger organs rather than several smaller ones. Thus, Notch plays an essential role in coordinating actomyosin induced cell shape changes and their …
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MOLECULAR PHYSIOLOGY OF BLOOD-BRAIN BARRIER TIGHT JUNCTIONS
… of the BBB see from the perspective of its tight junctions (TJ). Tight junctions are a protein-protein adhesion structures that seal the paracellular space for small solutes. Tight junctions are a common feature in many epithelial and endothelial tissues and a crucial component of the BBB. …
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Requirements for digestible calcium by growing pigs
… Ca absorption (i.e., TRPV6 and S100G) and tight junction proteins (i.e., OCLN and ZO1) in the duodenum. Twenty corn-soybean meal based diets were formulated to contain 0.16, 0.33, 0.42, or 0.50% STTD P and 0.14, 0.29, 0.44, 0.59, or 0.74% STTD Ca. A total of 640 pigs (11.1 ± 1.4 kg) were …
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The Apical Polarity Complex Protein, Pals1, Regulates Cell Fate In The Development of Cerebellum and Neocortex
… and function within the cell, polarity complex proteins are necessary to establish the cellular asymmetry required for tissue organization. Well-characterized germinal zones, mitogenic signals, and cell types make the cerebellum and neocortex excellent models to address the critical function of …
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Mechanisms of Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model
… inhibition confers neuroprotection by reducing tight junction proteins (TJPs) degradation and preserve BBB integrity. Moreover, acute MMPs inhibition provides long term neuroprotection and neurological function recovery against neonatal HI brain injury.</p> <p>Rice-Vannucci model of neonatal HI …
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From the body to the brain: Studying drug delivery and physiological interactions using MRI
… selective collection of endothelial cells and tight junction proteins that restrict passage of extracerebral substances from the blood vessels into the brain tissue. We disrupted and bypassed the BBB to deliver an MRI contrast agent and quantitatively assessed the resulting contrast dynamics. …
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The Role of Claudins in Bone Metabolism
… caudins (Cldns), which comprise a major group of tight junction proteins, in bone biology and development. This notion is based on our previous studies which demonstrated that Cldn-18 knockout (KO) mice developed osteopenia phenotype by increasing bone resorption and osteoclast differentiation. …
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Investigating the potential utilisation of black soldier fly (Hermetia illucens) as an alternative protein source in tilapia and carp feed
… intestinal cytokines (il1β, tnfα, il10, tgfβ), tight junction proteins (cldn3, ocln), and mucosal immunity markers (IgM, pIgR, muc2) were unaffected, while β-defensin 1, pcna, and hsp70 were downregulated. While microbiota diversity remained stable across the diets, BSF frass reduced …
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Characterization and Molecular Analysis of Fragilysin: The Bacteroides fragilis Toxin
… zinc per molecule, and it hydrolyzed a number of proteins, including gelatin. Optimal proteolytic activity occurred at 37° C and pH 6.5. Activity was inhibited by metal chelators but not by inhibitors of other classes of proteinases. When fragilysin is injected into ligated ileal and colonic loops …
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Prevalence and impact of Malaria infection on pregnancy and prenatal outcomes in the Blue Nile state of Sudan
… crosses the placental barrier. The role of tight junction proteins in the placenta with regards to the crossing of the parasites through the placental barrier will be investigated. A cross-sectional study has been conducted with 336 pregnant women. The mean (SD) maternal age was (25.13 ± …
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EphA4 Influences Blood Brain Barrier Disruption and Endothelial Cell Response following Traumatic Brain Injury in a Mouse Model
… increased mRNA expression of Tie2, Ang1, and the tight junction proteins Zona Occludens and Occludin in KO mice compared to WT. As well as, connection with neuronal processes. Based off of these findings, we utilized a soluble Tie2 inhibitor to elucidate the influence of Eph receptors on the …
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Molekulare Analyse des probiotischen Stamms Escherichia coli Nissle 1917
… zu einer gesteigerten mRNA-Expression des Tight-junction Proteins ZO-1 führt. Des Weiteren führte die Untersuchung von EcN-Deletionsmutanten zu der Schlussfolgerung, dass einige genomische Inseln für Eigenschaften, die das probiotische Verhalten erklären können, eine Rolle spielen. Durch …
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Generation and Characterization of Human Blood-Brain Barrier Models for Investigating Neuropsychiatric Disorders and Tumor Metastasis
… to ~62% of the control values. Correspondingly, tight junction proteins and the endothelial glycocalyx that determine the integrity of the BBB are significantly disrupted. It was also found that CRKL, a gene within the 22q11.2 DS deletion region, contributes to the deficit. The CRKL is a major …
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