Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"thyroid hormone receptor"”.
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Decreased Triiodothyronine Binding to the Hepatic Nuclear Thyroid Hormone Receptor in the Diabetic Mouse
… C57BL/KsJ-<em>db m</em> mouse has abnormal thyroid hormone levels and indications of thyroid hormone resistance. To investigate the basis of these abnormalities, the hepatic nuclear thyroid hormone receptor was extracted with 0.4 M KCl, 1.1 mM MgCl<sub>2</sub>, 20 mM Tris/HCl, pH 7.9 from …
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Effect of the ligands of thyroid hormone receptor on non-alcoholic fatty liver disease
… disease. Here, we examined the effect of the thyroid hormone triiodothyronine (T3) and the agonist of the thyroid hormone receptor β isoform (TRβ), GC-1, on fatty liver and steatohepatitis induced in rodents by a choline-deficient, methionine-restricted (CMD) diet. Male Fischer rats fed the …
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Molecular Dynamics Study of Hormone Receptors Binding DNA and Hormones
… of modified DNA, binding of the estrogen receptor to specific and non-specific DNA, and binding/unbinding of hormones to/from retinoic acid receptor and thyroid hormone receptor. In the DNA dodecamer, d(CGCGAATTCGCG), two Adenine residues, individually or jointly, were replaced with the 2 …
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Retinoic Acid Regulation of Thyroid Hormone Action in Bone Cells
<p>Retinoic acid and thyroid hormone are known to play key roles in the regulation of endochondral ossification. However, the issue of whether these two hormones interact with each other to regulate bone functions remains to be established. We investigated how thyroid hormone and retinoic acid …
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Isolation and Characterization of Estrogen Receptor- Interacting Proteins
… of physiological roles through its nuclear receptors, estrogen receptors (ERs). The action of ERs is modulated and mediated by diverse interacting cofactors. The initial aim of this thesis work was to identify ligand-, subtype- and/or cell typespecific ER-interacting proteins. I identified a …
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Identification of Phosphorylase Kinase Alpha Subunit Binding Partners in Skeletal Muscle
… being isolated of which 8 were identified as thyroid hormone receptor interacting protein 10 (TRIP10). TRIP10, also known as Cdc42 interacting protein 4 (CIP4), is highly expressed in skeletal muscle and is thought to act as a regulator of the actin cytoskeleton. The remaining 5 clones were …
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Transcriptional Regulation of Cardio-Pulmonary Development
… transcription factor (Btf), which was similar to thyroid hormone receptor associated protein 150 (TRAP150), was down regulated in dHAND mutants. TRAPs are a family of transcriptional co-activators that are required for normal cardiac and embryonic development. Mice lacking Btf showed normal …
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Targeting LGALS3 to treat steatotic liver disease and hepatocarcinogenesis
… of T3 and MGL-3196 (a selective agonist of the thyroid hormone receptor β-isoform) on neutral lipid content and collagen accumulation. The gene silencing was then combined with the administration of either T3 or MGL-3196, to evaluate the possible involvement of Gal-3 in the effects mediated by …
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Exploring the Multifaceted Life of Beige Adipocytes
… driven by a postnatal surge in circulating thyroid hormone, likely mediated through thyroid hormone receptor beta. We also revealed that macrophages can accelerate the lineage progression of these progenitor cells and increase the abundance of beige precursor cells. In adulthood, we examined …
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Role of the LPA2 Receptor in Protecting Against Apoptosis
… protection. In RH7777 cells lacking LPA receptors, OTP selectively protected LPA<sub>2</sub> but not LPA<sub>1</sub> and LPA<sub>3</sub> transfectants. In C57BL/6 and LPA<sub>1</sub> knockout mice exposed to 15 Gy g-irradiation, orally applied OTP reduced the number of apoptotic bodies …
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Intergenerational and Transgenerational Effects of Endocrine Insults
… synthetic glucocorticoids (sGCs), and hyperthyroidism – in two different species, humans and mice. EDCs are exogenous substances that interfere with endocrine axes to cause adverse health effects. Humans are ubiquitously exposed to EDCs and recent animal studies have suggested a role for …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
… reported that PDK4 gene expression is induced by thyroid hormone (T3). These studies did not investigate the mechanisms by which T3 regulated PDK4 gene expression. I have examined the role of the thyroid hormone receptor (TR), transcriptional coactivators especially the peroxisome proliferator …
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Genetic Analysis of Variation in Neuron Number
… to Chr 16 at 41.5 cM and has a LOD score of 6.0. Thyroid hormone receptor alpha (Thra) was identified as a superb candidate gene for Nnc1. I tested Thra as a candidate by comparing the ganglion cell number in transgenic mice carrying a null transgene at the Thra locus with ganglion cell number …