Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"thyroglobulin"”.
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MOLECULAR RECOGNITION OF THYROGLOBULIN BY SORTILIN
Thyroglobulin (TG) is a large glycoprotein essential for thyroid hormone synthesis and storage. Synthesised and secreted by thyrocytes, TG forms a dimeric structure within the thyroid follicle lumen, where it undergoes iodination and hormonogenesis before being retrieved through endocytosis for …
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Identification and characterization of a receptor for Clostridium Difficile enterotoxin
… the binding activity. The glycoprotein, calf thyroglobulin, also bound the toxin and inhibited toxin binding to cells. An efficient, single-step method for isolation of highly purified toxin A from C. difficile culture filtrate has been developed based on toxin association with calf …
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Optimization of large beaded cellulose as a chromatographic support
… the permeability of large proteins such as thyroglobulin and p-Amylase into the beaded matrix at bead contacting times of 5 and 50 seconds. The amount of permeation in 3% cellulose beads by thyroglobulin at bead contacting times of 5 seconds was about tenfold larger than predicted by …
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Examining autoimmune sequelae during cancer immunotherapy in a combined autoimmune thyroiditis and tumor mouse model
… thyroiditis with repeated doses of mouse thyroglobulin (mTg) without adjuvant. To simulate cancer patients, we developed a combined EAT and tumor model in our EAT-susceptible mice (CBA/J). In first establishing the tumor model, we found Treg depletion and irradiated tumor cell immunization …
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Functional Characterization of the C-terminal Cholinesterase-Like (ChEL) Domain of the Thyroid Hormone Precursor Protein
… known precursor for thyroid hormone synthesis is thyroglobulin (Tg), composed of upstream regions I-II-III and a C-terminal cholinesterase-like (ChEL) domain, which bears 47% similarity to acetylcholinesterase (AChE). Mutations in Tg cause congenital hypothyroidism, the most common congenital …
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Novel customisable phases for micro solid-phase extraction and automated biological sample preparation
… proteins (bovine serum albumin, cytochrome c and thyroglobulin) and a human serum sample were analysed, and compared to conventional in-solution digestion by employing liquid chromatography orbitrap mass spectrometry (LC-OT-MS) and liquid chromatography quadrupole time of flight mass spectrometry …
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The risk and severity of preeclampsia secondary to iodine deficiency and iodine deficiency-mediated subclinical hypothyroidism: mechanisms and early cardiovascular consequences
… assaying the urinary iodine concentration (UIC), thyroglobulin (Tg), thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), nitric oxide (NO), oxidised low-density lipoprotein (oxLDL), pulse wave velocity (PWV) and aortic augmentation index (AI). In the third part of the thesis, …
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Toward catalytic antibodies capable of ergopeptine hydrolysis
… emulator was conjugated to Bovine Serum Albumin, Thyroglobulin and Keyhole Limpet Haemocyanin. Sheep, mice and a rabbit were immunised with the resulting conjugate material. The immune rabbit serum was found to rapidly hydrolyse ester ((C₆H₅)CH₂COO(C₆H₄NO₂)) relative to the non-immune serum, …
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Polymorphisms of High-affinity IgE Receptor Genes in Patients with Aspirin-Intolerant Chronic Urticaria
… associated with the prevalence of anti-thyroglobulin antibody (p = 0.011) in AICU patients. When the effect of the FcεRI polymorphisms on the histamine releasability of peripheral blood basophils from AICU patients was analyzed, the histamine releasability of the patients carrying …
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METABOLIC AND PHARMACOKINETIC STUDIES OF BENZTROPINE AND TRIHEXYPHENIDYL
… were coupled to bovine serum albumin or porcine thyroglobulin to obtain the respective hapten-protein conjugates. Polyclonal antibodies to each hapten-protein conjugate were raised in New Zealand white rabbits and the titers of the developed antisera were determined by evaluating their binding to …
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Relación entre la presencia de tiroiditis linfocítica con la gravedad y recurrencia/persistencia del carcinoma diferenciado de tiroides.
Introducción: Para el sistema endocrino la neoplasia más frecuente es el cáncer diferenciado de tiroides, con un claro incremento en su incidencia. Es importante encontrar asociaciones que posteriormente permitan establecer factores de riesgo y/o protectores claves en la estrategia terapéutica …
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Relación de la tiroglobulina pre-ablación con la recurrencia/persistencia temprana del cáncer diferenciado de tiroides
Introducción: El cáncer diferenciado de tiroides es la neoplasia endocrina más frecuente en Colombia y su incidencia crece de forma acelerada. Se investigo la relación entre los niveles de tiroglobulina (Tg) pre-ablación y la persistencia/recurrencia temprana del cáncer diferenciado de tiroides. …
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Valore predittivo di recidiva/persistenza di malattia della VII e VIII edizione del sistema di stadiazione TNM e del sistema di stratificazione del rischio (2015 e 2009) dell'American Thyroid Association in una serie prospettica consecutiva di 451 pazienti con carcinoma differenziato tiroideo. Proposta di un nomogramma predittivo di recidiva o persistenza di malattia
… "Stratificazione ongoing del rischio" attraverso Thyroglobulin, anticorpi anti-tireoglobulina (TgAb), ecografia del collo, scintigrafia total-body post-131-I o altri esami morfologici. Le linee guida americane pubblicate nel 2015 hanno introdotto un nuovo sistema di stratificazione del rischio per …
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Chromatografischer Nachweis endogen radioiodierter Verbindungen im Urin von Patienten mit differenziertem Schilddrüsenkarzinom nach Iod-131-Ganzkörperszintigrafie
Der Follow-UP von Patienten mit differenziertem Schilddrüsenkarzinom (DTC) wird konventionell mit I-131-Ganzkörperzintigrafie (GKS) und Bestimmung des Serumthyreoglobulins (hTg) durchgeführt. Wegen der Inzidenz von 15%-20% diskordanter Resultate entwickelte Bianchi et al. (J Nucl Med 1993; 34: …