Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"thymocyte development"”.
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A T cell receptor transgenic approach to the study of thymocyte development and autoimmune disease
… in activation of the T cell. On an immature thymocyte, such recognition may result in either positive selection, allowing the cell to mature, or negative selection, eliminating that T cell clone from the host's repertoire. The parameters that determine thymocyte fate have remained unclear. An …
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Delineating the Role of CD244 in NK Cell Cytotoxicity and the Contribution of Ly108 to Thymocyte Development
… receptor, Ly108 in B6 and B6.Sle1b mice alters thymocyte differentiation and negative selection events leading to a break in tolerance of T cells in B6.Sle1b mice. This is due to differential affects of the isoforms of Ly108 on thymocyte cell cycle progression and sensitivity to apoptosis. These …
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
To analyze the role of protein kinase B(PKB)on developmental and functional aspects of T cells, we have generated transgenic mouse lines expressing a constitutively active form of PKB (myrPKB) in early stages of T cell development.Peripheral CD4+ T cells from PKB tg mice are hyperreactive, more …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… that are crucial during instruction of T cell development in the thymus and dendritic cell migration for initiation of adaptive immune responses. Within the thymus CCL19, CCL21 and CCL25 direct CCR7- and CCR9-expressing thymocytes through distinct thymic compartments, enabling development of a …
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The Influence of the Microbiota on T Cell Development
T cell development occurs in the thymus and is a complex and well-regulated process. Errors during this process can lead to immunodeficiencies and autoimmunity. This project will also look at recent thymic emigrants (RTEs). RTEs are the most immature subset and have been shown to have distinct …
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
… of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. We used the non-obese diabetic mouse (NOD) which is spontaneously developing T1D and have been described to have defects in the T cell maturation. By studying the apoptosis …
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Roles of CTCF and YY1 in T Cell Receptor Gene Rearrangement And T Cell Development
… and V(D)J recombination follows an intricate developmental program to assemble both TCRδ and TCRα repertoires. However, the mechanisms that dictate the developmental regulation of V(D)J recombination of the Tcra-Tcrd locus remain unclear. </p><p>We have previously shown that CCCTC-binding …
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Role of Notch Signaling and GATA-3 in Establishing T-lineage Commitment and Survival in Developing Thymocytes
… the precise molecular signals needed for the development of these cells are still not clearly defined. The Notch signaling pathway is required to commit progenitors to the T-lineage and acts in concert with many transcription factors such as GATA-3 to fully induce this fate choice while …
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The roles of Cabin1 and Left1 in T cell development
… Although mutant mice exhibited normal lymphocyte development and thymocyte apoptosis, they had elevated levels of serum IgG 1, IgG2b and IgE and produced more IgG1 and IgG2b in response to a T-dependent antigen. The increased antibody production is apparently not due to changes in immunoglobulin …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… a proper adaptive immune response by regulating thymocyte development and establishing central tolerance. In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is thought to regulate cell survival, proliferation, …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… not been fully elucidated. Previous studies of thymocyte development <italic> in vitro</italic> indicate that double negative: CD4<super>&minus</super>CD8<super>&minus</super>, DN) thymocytes can develop into cells with NK cell markers, but these cells have not been well characterized. Moreover, …
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The Function of LAT in T Cell Activation and Autoimmunity
… syndrome. These mice have defective thymic development and selection and lack natural regulatory T cells, implicating a breakdown of both central and peripheral tolerance. The phenotype observed in LAT-/- mice is even more severe.T cells are absent in the periphery of these mice due to a …
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Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
… thymic epithelial cells (TEC) with migrating thymocytes is of fundamental importance in driving thymocyte differentiation and their selection towards generation of an immunocompetent but self-tolerant T cell repertoire. While the ontogeny, phenotype and functionality of TEC subsets has been …
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Regulation of the Alpha and Delta T Cell Receptor Repertoires
… also plays a role in recombination. Early in thymocyte development, the Tcra-Tcrd locus is contracted. During this period, Tcrd recombinations are capable of assembling segments distal in linear space. Later in development, when Tcra recombines, the locus is decontracted, and rearrangements …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… FOXO1 and FOXO3 expression during T cell development and in peripheral T cells ex vivo. We show that the expression of FOXO1 increases with thymocyte development and is abundantly expressed in conventional naïve and effector T lymphocytes. Conversely, we found that FOXO3 is highly …
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Intrinsic Mechanisms that Regulate T Cell Homeostasis and Function
… of TSC1 at the double-positive (DP) stage of thymocyte development has several profound effects on T cell signaling, homeostasis and survival. Specifically, the loss TSC1 in T cells results in constitutive activation of mTORC1 and decreased activation of mTORC2. Reduced T cell numbers were …
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Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age
<p>The thymus maintains T cell receptor (TCR) repertoire diversity through perpetual release of self-MHC restricted naive T cells. However, thymus involution during the aging process reduces naïve T cell output, leading to defective immune responsiveness to newly encountered antigens. We have found …