Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"thymocyte"”.
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Genetic analysis of thymocyte apoptosis
… Receptor (GR) activates apoptosis in immature thymocytes through a mechanism that requires transactivation and repression of gene transcription. Several targets of GR regulation have been identified, including Glutathione-S-Transferase M1 (GSTM1) and Nur77 expression, and NFB function, however …
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The effects of nitrosoureas on Thymocyte differentiation and T cell activation
Earlier studies have demonstrated that nitrosoureas such as 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) and chlorozotocin (CLZ) can cure almost 100% of C57BL/6 mice bearing syngeneic LSA tumor. In contrast, similiar or higher doses of streptozotocin (STZ) completely failed to cure LSA-bearing …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… not been fully elucidated. Previous studies of thymocyte development <italic> in vitro</italic> indicate that double negative: CD4<super>&minus</super>CD8<super>&minus</super>, DN) thymocytes can develop into cells with NK cell markers, but these cells have not been well characterized. Moreover, …
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The mechanism of glucocorticoid induced murine thymocyte and peripheral T cell apoptosis
Glucocordicoide sind kleine lipophile Verbindungen, die viele biologische Effekte verursachen, wenn sie an den intrazellulären Glukokortikoidrezeptor (GR) binden. Dieser wandert wiederum in den Nucleus, um dort direkt oder indirekt die Transkription der Gene zu regulieren. Glukokortikoide sind der …
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Immunotoxic Effects of Mixtures of Endosulfan and Permethrin Via Caspase Dependent Thymocyte Apoptosis
… and their mixtures on C57/BL6 male mice thymocytes in vitro and to ascertain the mechanism by which these effects take place. Permethrin, a broad-spectrum synthetic pyrethroid, is a widely used insecticide in agriculture and public health. Endosulfan is a highly toxic chlorinated …
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A T cell receptor transgenic approach to the study of thymocyte development and autoimmune disease
… in activation of the T cell. On an immature thymocyte, such recognition may result in either positive selection, allowing the cell to mature, or negative selection, eliminating that T cell clone from the host's repertoire. The parameters that determine thymocyte fate have remained unclear. An …
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Delineating the Role of CD244 in NK Cell Cytotoxicity and the Contribution of Ly108 to Thymocyte Development
… receptor, Ly108 in B6 and B6.Sle1b mice alters thymocyte differentiation and negative selection events leading to a break in tolerance of T cells in B6.Sle1b mice. This is due to differential affects of the isoforms of Ly108 on thymocyte cell cycle progression and sensitivity to apoptosis. These …
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
… and myrPKB. dCam tg mice have a severe block in thymocyte development at the DN3 stage.But in the dCam/PKB double tg mice this developmental block is significantly rescued.This rescue of thymocyte development by PKB is due to the expression of RAG1 and subsequent TCRb chain expression. CsA …
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The Influence of the Microbiota on T Cell Development
… shaping the T cell receptor (TCR) repertoire in thymocytes. The impact of the microbiota on T cell development, however, still remains an understudied area of research. There has also been no published data exploring the effects of the microbiota on RTE phenotypes and functions. In this project, …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… CCL21 and CCL25 direct CCR7- and CCR9-expressing thymocytes through distinct thymic compartments, enabling development of a self-MHC restricted and self-tolerant peripheral T cell repertoire. Yet mechanisms outside of transcriptional control that are involved in thymic chemokine regulation have …
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Roles of CTCF and YY1 in T Cell Receptor Gene Rearrangement And T Cell Development
… the generation of the TCR repertoire during thymocyte development. Thus, we generated several mouse models with genetically modified CBEs to gain insight into the CTCF-dependent regulation of the Tcra-Tcrd locus. We revealed a CTCF-dependent chromatin interaction network at the Tcra-Tcrd …
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Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Diethylstilbestrol (DES) in the Fetal Mouse Thymus and Liver
… as immunotoxicants causing thymic atrophy, thymocyte hypocellularity, phenotypic changes detected by CD4 and CD8 surface antigens, and progenitor T-cell targeting in the fetal mouse. We hypothesized that gestational exposure to these two compounds may lead to comparable histologic and gene …
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
… of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. We used the non-obese diabetic mouse (NOD) which is spontaneously developing T1D and have been described to have defects in the T cell maturation. By studying the apoptosis …
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The Major Histocompatibility Complex (MHC) and the proteasome-ubiquitin pathway in T cell development
… inhibitors to implicate the proteasome in thymocyte apoptosis and negative selection. We find that proteasome inhibitors do not completely block but rather delay both dexamethasone- and antigen-triggered thymocyte apoptosis. We also show that proteasome activity is increased in apoptotic …
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Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
… thymic epithelial cells (TEC) with migrating thymocytes is of fundamental importance in driving thymocyte differentiation and their selection towards generation of an immunocompetent but self-tolerant T cell repertoire. While the ontogeny, phenotype and functionality of TEC subsets has been …
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Role of Notch Signaling and GATA-3 in Establishing T-lineage Commitment and Survival in Developing Thymocytes
… both Notch and GATA-3 are indispensible for thymocyte development, their precise roles in directing these events remain to be elucidated. Examining such phenomena during ontogeny has been prohibited by genetic lethality caused by deletion of these genes early in development. Work presented in …
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The roles of Cabin1 and Left1 in T cell development
… mice exhibited normal lymphocyte development and thymocyte apoptosis, they had elevated levels of serum IgG 1, IgG2b and IgE and produced more IgG1 and IgG2b in response to a T-dependent antigen. The increased antibody production is apparently not due to changes in immunoglobulin class switching …
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The Phytoestrogen Genistein Induces Thymic and Immune Changes: A Human Health Concern
… and wild-type animals. Genistein decreased thymocyte numbers up to 86% and doubled apoptosis, indicating that the mechanism of the genistein effect on loss of thymocytes is due in part to increased apoptosis. Genistein injection caused decreases in relative percentages of thymic CD4+CD8- and …
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… thymus is predominantly composed of developing thymocytes and specialized epithelial cells. The type of stress predicates whether the thymocytes or epithelial cells initiate the involutionary response. MicroRNAs (miRs) are small non-coding RNAs ~18-22 nucleotides in length that maintain cellular …
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Aspects of T cell development contributing to autoimmunity.
… transfer. Our analysis revealed no difference in thymocyte distribution or apoptosis induction indicating that TGF-β is dispensable in these aspects. We did however observe increased proliferation of CD8+ thymocytes which might contribute to the immune defect in these animals. The impact of thymic …
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