Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 153 for “"thymidine"”.
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Design of thymidine-based inhibitors of Mycobacterium tuberculosis thymidylate kinase
… naar krachtige en selectieve inhibitoren van het thymidine monophoshate kinase van Mycobacterium tuberculosis (TMPKmt), beschrijft dit werk de ontwikkeling van nieuwe anti-tuberculose geneesmiddelen. Aangezien TMPKmt een essentieel enzyme is voor de groei van de bacterie, kunnen inhibitoren van …
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Synthesis and Biological Evaluation of Modified Adenosine and Thymidine Nucleoside Analogues
… we de synthese van gemodificeerde adenosine en thymidine analogen (zie Figuur 1). Deze verbindingen werden als moleculaire probes gebruikt voor de biologische evaluatie van adenosine-receptoren (ARn, Deel II, Hoofdstuk 3-6), die behoren tot de G-proteïne gekoppelde receptor (GPCR) superfamilie, …
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Total synthesis of a Furan-side psoralen-thymidine monoadduct and its biochemical applications
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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Quantitation of contact sensitivity responses in the mouse by 3H-thymidine labeling of lymphocytes
Thesis (M.S.)--Michigan State University. Dept. of Microbiology and Public Health, 1974
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Mechanisms of Cell Death Initiated in Herpes Simplex Virus Thymidine Kinase Expressing Colon Tumor Cells Treated with Ganciclovir and UCN-01
… Heterologous expression of Herpes Simplex Virus Thymidine Kinase (HSVtk) in combination with the prodrug, ganciclovir (GCV), has shown great promise for the genetic therapy of many cancers, but most patients have had only a partial or minimal response to the therapy. After screening a panel of …
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Cell Kinetics of Osteoblast Histogenesis in Evolving Rabbit Secondary Haversian Systems Using a Double Labeling Technique with [³H]-Thymidine and Bromodeoxyuridine
… Using a double-labeling method with [3 H]-thymidine and bromodeoxyuridine (BrdU), this study examined cell kinetics in 120 SHSs per rabbit at 12 hour intervals up to 72 hours after labeling. A total of 7 rabbits were injected with alizarin complexone (-1 O days: 20 mg/kg/day), tetracycline …
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Reconstitution of a Multi-layered, Differentiated Cornea by HTERT-Immortalized Corneal Epithelial Cells Transduced with Thymidine Kinase Transplanted onto Denuded Mouse Corneas
… line (hTCEpi) transduced with the hygromycin-thymidine kinase gene (HyTK) as a viable cell source for the reconstruction of the corneal surface. METHODS: HyTK cells were cultured in KGM-2 serum-free culture media under hygromycin B selection. Limbal stem cell deficiency (LSCD) was established …
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The promise and perils of molecular combing
… solution, NaOH exposure time, and halogenated thymidine exposure time in yeast (Saccharomyces cerevisiae). A serial pH experiment is necessary to determine optimal pH in any given laboratory. The optimal NaOH exposure time is 20 minutes. Despite using flow cytometry to determine the amount of …
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Biological Consequences Of Complex Dna Lesions Induced By Bis-Electrophiles
… was used to generate DPCs involving the C5–thymidine of DNA. Replication bypass using human translesion synthesis polymerases η and κ revealed that large polypeptides cross–linked to either 7–deazaguanine or C5–thymidine completely blocked replication, while the corresponding decapeptide …
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The isolation, partial purification and preliminary characterization of a growth factor from chick embryo brains
… regeneration. In addition, CBGF stimulates 3H-thymidine incorporation in chick embryo brain astrocytes in vitro. In this study, cultured chick embryo brain non-neuronal cells were employed in a bioassay to monitor CBGF activity throughout various stages of its pllrification. Cell culture and …
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Potential roles for transforming growth factor-B during terminal differentiation of ocular lens cells /
… marker protein, phakinin. Measures of tritiated thymidine incorporation demonstrated that TGF-β stimulated, in a dose-dependent manner, cellular growth and spreading. The production of collagen type IV and fibronectin were detected in TGF-β stimulated CLAP cells using immunoblotting techniques …
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The Origin of Genome Instability in Cancer: Role of the Fragile Site Gene Product FHIT
… triphosphate pool and an insufficient supply of thymidine triphosphate. FHIT up-regulates the S-phase-specific expression of thymidine kinase 1, a component of the pyrimidine salvage pathway for the production of thymidine triphosphate. Balanced precursors of DNA are needed for efficient and …
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Tumor Response TCF-4/β-Catenin Regulatory Elements for Enhancing Cancer Gene Therapies
… and c-fos promoter linked with the herpes virus thymidine kinase suicide gene in combination with ganciclovir was further evaluated in the normal and tumor cell lines. The Tcf-4/β-catenin elements conferred tumor specific expression of HSV thymidine kinase (HSV-TK) gene, resulting in selective …
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