Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"thymic epithelial"”.
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Development and Maintenance of Thymic Epithelial Microenvironment
… development and selection Of T-‐cells. The thymic microenvironment, however, undergoes age related involution, Resulting in a reduction of the repertoire of T-‐cells that are produced, and a decreased Capacity to respond to new antigen. Even though significant thymic epithelial turnover …
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Development and Maintenance of the Thymic Epithelial Microenvironment
… the functional self-tolerant T-cell population. Thymic epithelial cells play an essential role in the development of a naïve, self-tolerant T-cell population. Paradoxically thymus undergoes acute age-related involution, which in turn causes loss of functional T-cell populations. Involution …
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Enforced Expression of Tbx1 In Fetal Thymic Epithelial Cells Antagonizes Thymus Organogenesis
… expression of <em>Tbx1</em> in fetal thymic epithelial cells antagonizes</strong></p> <p><strong>thymus organogenesis</strong></p> <p>Kim T. Cardenas</p> <p>The thymus and parathyroid glands originate from organ-specific domains of 3rd pharyngeal pouch (PP) endoderm. At embryonic day …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
<p>Thymic epithelial cells (TEC) are essential for a proper adaptive immune response by regulating thymocyte development and establishing central tolerance. In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is …
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… a transient involution that can reduce overall thymic volume up to 90%. The thymus is predominantly composed of developing thymocytes and specialized epithelial cells. The type of stress predicates whether the thymocytes or epithelial cells initiate the involutionary response. MicroRNAs (miRs) …
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Determination of Thymic Epithelial Cell Composition and Proliferation During The Perinatal to Adult Transition
… from multiple stromal cell types, particularly thymic epithelial cells (TECs). The thymus develops rapidly during the perinatal time period (birth – 10 days in mice) before reaching a period of homeostasis (10 days – 6 weeks). The mechanisms that initially promote and subsequently limit …
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The development and function of thymic microenvironments
… a diverse and self-tolerant T-cell repertoire. Thymic epithelial cells (TEC) represent a key stromal cell type during defined stages in T cell development, yet the mechanisms regulating their development are only partly understood. An ontogenetic approach was employed to study stages of cortical …
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Epigenetic analysis of promiscuous gene expression in central tolerance
… restricted antigens (TRA) within medullary thymic epithelial cells in a process known as promiscuous gene expression (PGE). Here we demonstrate how AIRE influences PGE through a direct impact on post-translational modifications of core histones which are associated with the regulation of …
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Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age
… 5 promoter-driven Cyclin D1 (K5.D1) transgene in thymic epithelial cells (TECs). Thymopoiesis occurs normally in K5.D1 transgenic thymi and sustains T cell output to prevent the age-associated decline of naïve T cells in the periphery. We find that K5.D1 recent thymic emigrants (RTEs) undergo …
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Characterizing the role of thymic interferon in T cell development and selection
… produced by a very small number of AIRE+ thymic epithelial cells, independent of microbial stimulation. Antigen presenting cells were highly responsive to thymic IFNs and IFNs were required for the activation and maturation of thymic DC1, macrophages and B cells. Loss of IFN-sensing led to …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… and CCR9-expressing thymocytes through distinct thymic compartments, enabling development of a self-MHC restricted and self-tolerant peripheral T cell repertoire. Yet mechanisms outside of transcriptional control that are involved in thymic chemokine regulation have not been well characterised. …
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DISSECTING IMMUNE DYSREGULATION IN PATIENTS WITHTHYMIC EPITHELIAL TUMORS BY AUTOANTIBODY ANDSINGLE-CELL PROFILING
Thymic epithelial lesions (TELs) are a heterogeneous and rare group of diseases arising from the epithelial cells of the thymus. TELs include both benign conditions, such as thymic hyperplasia (TH), and malignant lesions, collectively referred to as thymic epithelial tumors (TETs). According to the …
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Promoting Thymopoiesis with Age: Potential Role of the Transcription Factor Foxn1
… (ETP) binds to its ligand expressed on thymic epithelial cells (TEC), signaling ETP to develop through a series of developmental stages before maturing into naive T cells. Because ETP are non-self renewing, the thymus relies on the bone marrow (BM) for a continuous supply of T cell …
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Investigating lymphocyte development in the foetal thymus and modulation by the melanocortin 5 receptor
… imaging I investigated the temporal stages of thymic innate lymphoid cell development. I found that NK cell progenitors (NKp) were first visible at embryonic (E) day E13.5, followed by the appearance of ILC2 progenitors (ILC2p) and developing T cells. Notably, the NKp and ILC2p formed clusters …
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Defining The Molecular Networks Necessary For Thymus Fate and Organogenesis
… that ectopic expression of <em>Tbx1 </em>in thymic epithelial cells (TECs) suppresses FOXN1, inhibits TEC proliferation and arrests TEC differentiation, suggesting <em>Tbx1</em> must be tightly regulated in the 3<sup>rd</sup> pp endoderm for proper thymus organogenesis to occur. Members of …
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Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
… and medullary regions that are composed of epithelial and mesenchymal stromal elements. The interaction of cortical (cTEC) and medullary (mTEC) thymic epithelial cells (TEC) with migrating thymocytes is of fundamental importance in driving thymocyte differentiation and their selection …
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Bone Marrow Derived Progenitor Cells and Their Contributions to the Thymic Stroma
… in significant decline in T-cell function.Thymic epithelial cells (TECs) are the most critical component of the thymic microenvironment and undergo rapid turn-over, so understanding the cellular mechanisms responsible for the maintenance of TEC number and organization will be critical in …
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Single-cell atlasing of the human tissues across the lifespan
… T cells and supporting resident cells, including thymic epithelial cells (TECs), fibroblasts, vascular and myeloid cells. Simultaneously, I use the cortico-medullary axis to compare the spatial position of cell types in the fetal vs. paediatric thymus. I conclude by discussing the differences in …
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Comparative Immunological Effects of a Natural Estrogen (17β-estradiol) versus a Pharmacologic Synthetic Estrogen (17α-ethinyl estradiol)
… administered. Additionally, like E2, EE induced thymic atrophy in both sexes. In female mice, thymic atrophy and thymic cellularity were significantly decreased by subcutaneous EE and E2 at doses of 0.4 and 4.0 μg/25 g body weights. EE elicited significantly more pronounced thymic …