Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"thymic development"”.
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Functional relationships among lck kinase and the lat and grb2 adaptors in the intracellular signaling cascade of the tcr/cd3 complex: implications in thymic development and lymphocyte activation
… T lymphocytes need to undergo processes of development, differentiation and activation in order to perform their functions, and for this purpose, they express the TCR receptor in their membrane, which upon activation triggers a very complex intracellular signaling. Failures in these …
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Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells
… but the molecular mechanisms underpinning their development remain elusive. In this study, we uncovered the roles of the molecules RAPTOR and PTEN in the thymic development of unconventional T cells. Capitalizing on genetic deletion of RAPTOR, we found RAPTOR-dependent mTORC1 signaling couples …
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Epigenetic analysis of promiscuous gene expression in central tolerance
… restricted antigens (TRA) within medullary thymic epithelial cells in a process known as promiscuous gene expression (PGE). Here we demonstrate how AIRE influences PGE through a direct impact on post-translational modifications of core histones which are associated with the regulation of …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
<p>Thymic epithelial cells (TEC) are essential for a proper adaptive immune response by regulating thymocyte development and establishing central tolerance. In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is …
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Intrinsic heterogeneity in the survival and proliferation capacities of naïve CD8⁺ T cells
… capacities of naive T cells, possibly during thymic development. Our estimates of spMHC-induced signals in OT-1 (CD5hi) and F5 (CD50) cells, based on cytosolic Ca2⁺ influx measurements, suggest that the differences in their lymphophenia-induced proliferation, which were previously attributed …
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Forkhead Transcription Factors Foxp1 and Foxp4 Regulate T Cell Development and Function
… factors regulate T cell fates at every stage of development and differentiation. Members of the FoxP family of Forkhead transcription factors are essential for normal T lineage development; Foxp3 is required for regulatory T cell generation and function, and Foxp1 is necessary for the development …
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Molecular interactions among insulin-like growth factor, its receptor and binding proteins on myeloid cells
… 25 kDa IGFBP as IGFBP-4 that was expressed in a thymic macrophage cell line (TMC). TMC cells secrete IGFBP-4 at approximately 373 ng/10$\sp7$ cells/day as determined by ligand blot followed by PhosphorImager analysis. RT-PCR amplification of TMC mRNA with primers designed from rat and human …
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TRANSCRIPTIONAL CONTROL OF Ca2+ SIGNALING IN T CELLS
… roles for EGR1, EGR2 and EGR3 in T cell development and function have been established, a role for EGR4 has not, hitherto been elucidated. In the second half of this thesis, using qPCR, I reveal that EGR4 expression is stimulated by TCR engagement in primary double positive, CD4 and CD8 …
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The Function of LAT in T Cell Activation and Autoimmunity
… syndrome. These mice have defective thymic development and selection and lack natural regulatory T cells, implicating a breakdown of both central and peripheral tolerance. The phenotype observed in LAT-/- mice is even more severe.T cells are absent in the periphery of these mice due …
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Development and Maintenance of the Thymic Epithelial Microenvironment
… the functional self-tolerant T-cell population. Thymic epithelial cells play an essential role in the development of a naïve, self-tolerant T-cell population. Paradoxically thymus undergoes acute age-related involution, which in turn causes loss of functional T-cell populations. Involution …
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Understanding Development of Human Immunity One Cell at a Time
… atlases of human tissues across multiple developmental stages. This is revealing the identity and function of cells at unprecedented resolution and depth, enhancing our understanding of the immune system in health and disease. The Human Cell Atlas data is also providing us with valuable …
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… undergo stringent positive selection during development to bind to peptides presented on self MHC. We hypothesize that T cells bind to peptides on non-self MHC using the same properties involved in binding their conventional ligands. We identified allostimulatory peptide-MHC (pMHC) ligands …
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Enforced Expression of Tbx1 In Fetal Thymic Epithelial Cells Antagonizes Thymus Organogenesis
… expression of <em>Tbx1</em> in fetal thymic epithelial cells antagonizes</strong></p> <p><strong>thymus organogenesis</strong></p> <p>Kim T. Cardenas</p> <p>The thymus and parathyroid glands originate from organ-specific domains of 3rd pharyngeal pouch (PP) endoderm. At embryonic day …