Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"thromboxane"”.
-
Synthesis of thromboxane A2 analogues.
The aim of the project was to synthesize novel thromboxane A2 analogues which would be potential thromboxane A2 antagonists. Three thromboxane A2 analogues were synthesized, methyl 7-[-5-(3-hydroxy-1-(E)-octenyl)-2-methylbicyclo[3.3.1]non-2-en-9-yl]-[syn]-(+/-)-5-(Z)-heptenoate, methyl …
-
MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… 1) a crucial intermediate enzyme involved in thromboxane biosynthesis. Clopidogrel on the other hand antagonizes ADP receptor P2Y12. ADP is a weak platelet agonist stored in platelet dense granules and is released upon platelet activation. ADP activates platelets through two purinergic …
-
Role Of Thromboxane Receptor-Alpha In Prostate Cancer Progression
<p>Thromboxane A2 (TXA2) is a major arachidonic acid metabolite that signals through TXA2 receptors (TP) to induce platelet aggregation and smooth muscle contraction. TXA2 receptors are expressed as two different isoforms in humans, namely TP-alpha (TPα) and TP-beta (TPβ), which have common and …
-
Targeting Thromboxane A2 Receptor Signaling in Breast Cancer Metastasis
… with malignant breast cancer. The receptor of thromboxane A2 (TxA2), TP, is a member of the G-protein coupled receptor family. Increased expression of TP at RNA level was found to correlate with a poor prognosis in breast cancer patients; however, it is unknown how TP expression and activities …
-
Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling
… prostaglandin endoperoxides then further into thromboxane B₂ through the unstable intermediate thromboxane A₂. Pinane thromboxane A₂ is a stable analog of the unstable thromboxane A₂ [2]. Its antithrombotic activity includes the inhibition of platelet aggregation, artery constriction, and …
-
The role of thromboxane A(2) receptor signaling in oligodendrocyte development.
The role of thromboxane A(2) receptor signaling in oligodendrocyte development.
-
Regulatory Function of MicroRNA-149 on Thromboxane A2 Receptor Gene Expression in Asthmatics
… TaqMan® MicroRNA Assays. The expression of the thromboxane A2 receptor (TBXA2R) gene in peripheral blood mononuclear cells (PBMCs) was measured by quantitative RT-PCR. Human Embryonic Kidney 293T (HEK293T) cells were transfected with an EGFP-tagged TBXA2R 3′UTR plasmid construct and a miR-149 …
-
Selective modulation of the platelet thromboxane A2/prostaglandin H2 receptor by omega-3 fatty acids.
Selective modulation of the platelet thromboxane A2/prostaglandin H2 receptor by omega-3 fatty acids.
-
Effects of thromboxane synthetase inhibition on blood cell function and morphology during ovine pregnancy-induced hypertension
… were observed during normal pregnancy, OPIH, and thromboxane synthetase inhibitor administration. Blood pressure, plasma thromboxane B2, serum chemistries and electrolytes, fibrin/fibrinogen degratory products, and total platelet count were monitored throughout the investigation to document the …
-
The Effect of a 20-25 calories % Fat Diet on Plasma Thromboxane B₂ Levels in Human Subjects
<p>Fourteen males with elevated blood lipids were given a 20-2.5 Calories % fat diet for 28 days. Fasting blood samples were drawn at zero, two, and four weeks and analyzed for plasma TXB₂ and serum lipids. Plasma TXB₂ was significantly increased the first two weeks with a subsequent decrease the …
-
Elucidating the role of membranes in modulating the thermodynamics and kinetics of substrate binding to Thromboxane Synthase
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2013-04-26T15:02:42Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Varma, Snehita.pdf: 1462422 bytes, checksum: 951f441072241284d93adc7f4f9fd9a0 (MD5)
-
Antiplatelet and antihypertensive actions of ridogrel
Thromboxane plays a principal role in platelet aggregation, and is a potent vasoconstrictor. It is now understoood, that the receptor for thromboxane (TP) responds to multiple endogenous ligands. Inhibiting the synthesis of thromboxane does not prevent functional responses mediated by TP receptors. …
-
Production of prostaglandin E2 and thromboxane A2 by rat liver macrophages and involvement of nitric oxide and cytokines in mediator pathways under inflammatory conditions
… there are prostanoids (prostaglandin (PG) E2 and thromboxane (Tx) A2), cytokines (e.g. interleukin (IL)-1,-6, -10, tumor necrosis factor (TNF) α) and inorganic mediators like nitric oxide (NO). Macrophages-derived products play opposing roles in the development of liver fibrogenesis: IL-1β, TNFα, …
-
Rôle modulateur de l'oxyde nitrique dans la vasoconstriction et l'élévation du calcium intracellulaire induites par l'endothéline-1 et le thromboxane A[indice inférieur 2] dans des vaisseaux humains et de lapins
… comme l'endothéline-1 (ET-1) et le thromboxane A[indice inférieur 2] (TXA[indice inférieur 2]), ainsi que des substances relaxantes tel l'oxyde nitrique (NO). Ces facteurs sont importants dans la modulation du tonus vasculaire et un débalancement dans leurs niveaux est associé à …
-
Inflammation, Phagocytosis and Effect of Flunixin Meglumine During Endotoxin-Induced Mastitis (Therapy, Prostaglandins)
… mastitis: (1) milk concentrations of thromboxane B(,2) (TXB(,2)) and prostaglandin F(,2(alpha)) (PGF(,2(alpha))); (2) the pharmacokinetics of flunixin meglumine in lactating cattle; (3) the clinical efficacy of the flunixin meglumine and its effect on milk and plasma TXB(,2) and …
-
Psychological, cardiovascular and haematological aspects of the type A behaviour pattern in relation to coronary heart disease
… which control platelet function (the coagulatory thromboxane A2 , and the anticoagulatory prostacyclin). Different response patterns emerged prior to, and following a mental arithmetic challenge. The task anticipation effect involved elevated heart rate, systolic and diastolic pressure, plasma …
-
The Molecular Mechanism of Platelet Activation in Inflammation
… possibly including adenosine diphosphate (ADP), thromboxane A2 and toll-like receptors (TLRs), to drive platelet activation. This highlights the potential role of extracellular histones in thrombo-inflammatory diseases, including sepsis, trauma, and autoimmune conditions such as ANCA-associated …
-
The influence of the hormonal milieu on eicosanoid and cytokine production in tissues from the female reproductive tract.
… prostaglandins (PG) PGE2, PGD2, PGI2, PGF2¿ and Thromboxane A2 (TXA2), also termed prostanoids, are synthesised and deactivated to 15-keto PGE2, J2 metabolites, 6-keto-PGF1¿, 15-keto PGF2¿ and TXB2 respectively. However, not all metabolites have been analysed simultaneously within the same …
-
Genetic Polymorphism of Prostanoid Receptors, CRTH2 and TBXA2R in Aspirin Hypersensitivity
… confers elevated risk for developing AIA. Human Thromboxane A2 (TBXA2), is another eicosanoid product induced by cyclooxygenase may be as important mediator in aspirin hypersensitivity as it can induce bronchoconstriction and bronchohyperresponsiveness. TBXA2 exerts its action by interacting with …
-
Regulation of Protein Kinases (Syk and PKC zeta) in platelets
… systems leads to alpha IIb beta 3 activation, thromboxane generation, ADP release, etc., culminating in platelet clot or thrombus formation. The protein kinase family of enzymes mediates a significant number of these intracellular signaling events that culminate in platelet activation. These …
Page 1 of 3