Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"thrombotic microangiopathy"”.
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Genetic Factors Associated with Anti-Factor H Autoantibodies in Atypical Hemolytic Uremic Syndrome (aHUS)
… uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy characterized by renal failure and determined by genetic and acquired defects of alternative pathway (AP) of the complement system. Autoantibodies against factor H (anti-FHs), a regulator of the AP, were reported in 10% of …
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Trends in clinical presentation and treatment outcomes in a South African TTP cohort
… HIV is the most common cause of secondary thrombotic thrombocytopenic purpura (TTP) in South Africa. Objectives: To assess the clinical presentations and outcomes of patients treated for HIV-associated and idiopathic TTP. Methods: We conducted a retrospective cohort study of patients …
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Studies of ADAMTS13 expression and activity in the kidney
… thrombus growth. Dysfunctional ADAMTS13 leads to thrombotic thrombocytopenic purpura (TTP), which is either due to mutations (congenital TTP) or auto-antibodies (acquired TTP). The histopathological lesion is termed thrombotic microangiopathy and characterized by disseminated hyaline thrombi in …
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Studies of the pathogenesis of IgA nephropathy and Henoch-Schönlein purpura, with special reference to Streptococcus pyogenes infections and complement
… H gene (CFH) in a child with IgAN complicated by thrombotic microangiopathy (TMA) most probably triggered by malignant hypertension. In addition, three heterozygous CFH polymorphisms were identified, known to increase the risk for TMA. This genotype may thus have contributed to the combined …
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Characterization of Complement C3 Dysregulation Predisposing to Two Human Disease States
… Atypical hemolytic uremic syndrome: aHUS) is a thrombotic microangiopathy that primarily affects the kidneys. This disease is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Heterozygous mutations in the regulatory proteins Factor H, CD46 and Factor …
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Studies of EHEC and the complement system in renal diseases
This thesis addressed the diagnosis, pathogenesis and clinical course of specific renal diseases hemolytic uremic syndrome (HUS) and dense deposit disease (DDD). HUS may be associated with infection caused by Enterohemorrhagic Escherichia coli (EHEC) or with complement dysfunction due to complement …