Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"thrombopoietin"”.
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The Role of Kit and Thrombopoietin in Regulation of Hematopoietic Stem Cells
… and their respective ligands, Kit ligand and Thrombopoietin (Thpo), in regulation of HSC self-renewal. Using mice that have partial (KitW41/W41) and complete (Thpo-/-) loss of function mutations of the Kit receptor and Thpo ligand respectively, we have demonstrated a reduction of bone marrow …
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The role of thrombopoietin in promoting yolk sac hematopoietic progenitor cell growth and differentiation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Suppression of growth factor withdrawal-induced apoptosis in hematopoietic cells: biological consequences and molecular aspects of thrombopoietin stimulation in M07e cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Neue Enzyminhibitoren und Rezeptoragonisten durch Variation funktionaler Schleifen von Mikroproteinen
… als Monomere mit hoher Affinität an den humanen Thrombopoietin-Rezeptor binden und als linkerverbrückte Homodimere potente Thrombopoietin-Rezeptor Agonisten sind. Zudem konnten durch struktur-basiertes Design potente Inhibitoren der humanen Mastzell-Tryptase entwickelt werden, die alle vier …
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Evaluation of the actin architecture in dysplastic megakaryocytes expressing the NUP98-HOXD13 leukemic fusion gene
… flushed, cultured in media supplemented with thrombopoietin only or with estrogen to induce proplatelet formation, and MK harvested after 5 days. Harvested MK and BM cores were processed and analyzed by transmission electron microscopy (TEM) to detail the ultrastructural features. TEM of MK …
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Characterization of human myeloid progenitors and their differentiation
… inclusion of the growth factor receptor (GFR) thrombopoietin receptor (TpoR) in a previously presented immunophenotype definition of the human common myeloid progenitor (CMP), granulocyte/monocyte progenitor (GMP) and megakaryocyte/erythrocyte progenitor (MEP), significantly improved the …
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
… acting as an inhibitor of the cytokine Thrombopoietin, known to be important for HSC maintenance and/or expansion. Furthermore, whereas previous studies demonstrated that another cytokine, fms-like tyrosine kinase receptor 3 (FLT3) ligand (FL), is an important regulator of B cell …
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New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms
… and cell membrane, where it co-localised with thrombopoietin receptor. Interestingly, CALR cell surface expression increased during megakaryocyte commitment in CALR mutant cells, showing a dynamic process of CALR compartmentalisation during megakaryocyte differentiation. One of the more …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… c-MPL signaling by removal of its ligand, thrombopoietin (TPO), or addition of a c-MPL neutralizing antibody negated the anti-apoptotic effect of Nfix overexpression on cultured HSPC. Furthermore, NFIX-FLAG was capable of binding to and transcriptionally activating a proximal c-Mpl promoter …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
… Soluble biomarkers, including soluble (s) GPVI, thrombopoietin, and citrullinated histone-DNA complexes, were elevated in patients with bleeding. Integrin aIIbb3 activation remained functional but viscoelastic assays showed significantly impaired clot formation parameters. The 'platelet A10' …
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New approaches to improve the cord blood unit hematopoietic progenitor cell content
… to be due to the erythropoietic effect of thrombopoietin, endogenous erythropoietin production, and diverse cell-cell interactions in the culture. This observation underscores the complex interactions of cytokines and supporting cells in the heterogeneous cell population of the thawed cord …
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The Role of Platelets In Ovarian Carcinoma
… megakaryo- and thrombopoietic factors including thrombopoietin (TPO), IL-1a, IL-3, IL-4, IL-6, IL-11, G-CSF, GM-CSF, stem cell factor, and FLT-3 ligand were assayed in a subset of 150 patients at the time of initial diagnosis with advanced stage, high grade epithelial ovarian cancer using …