Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"thrombopoiesis"”.
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Novel insights into megakaryopoiesis, thrombopoiesis and acute coronary thrombosis: transcriptome profiling of the haematopoietic stem cell, megakaryocyte and platelet
… gain insights into steady state and accelerated thrombopoiesis that occurs in states of haemostatic demand and in thrombosis by applying these findings to the pathological setting of acute coronary thrombosis. To investigate transcriptional heterogeneity within the human HSC population, single …
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Fine mapping studies of quantitative trait loci for baseline platelet count in mice and humans
… of mapping genetic variants contributing to thrombopoiesis, despite the significant progresses which have been made at the technological, methodological and statistical levels in the field of complex trait mapping.
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
… platelet destruction and impaired thrombopoiesis. Patients with ITP display heterogeneous clinical trajectories and bleeding severity, often poorly correlated with platelet count, necessitating new biomarkers beyond platelet count to predict bleeding risk. A comprehensive analysis …
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Evaluating the Diagnostic Value and Molecular Mechanisms of Thrombocytosis in Lung Cancer
… established drivers of megakaryopoiesis and thrombopoiesis (p<0.001). These findings provide evidence of a direct mechanistic link between lung cancer cells and platelet biogenesis and suggest activation of a non-canonical pathway thrombopoietic pathway. Collectively, this thesis establishes …
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Cytokine receptor-like factor 3 (CRLF3): A novel regulator of platelet biogenesis and potential drug target for thrombocythaemia
… function and cytoreductive agents to decrease thrombopoiesis. The most commonly used cytoreductive agents are hydroxyurea, anagrelide and interferon-$alpha$ and all have unwanted side effects. Cytokine receptor-like factor 3 $(CRLF3)$ is a 2.4kb gene that is ubiquitously expressed throughout …
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The Role of Platelets In Ovarian Carcinoma
Platelets represent one of the largest storage pools of angiogenic and oncogenic growth factors in the human body. The observation that thrombocytosis (platelet count >450,000/uL) occurs in patients with solid malignancies was made over 100 years ago. However, the clinical and biological …