Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"thrombocytopenia"”.
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Plasma ADAMTS13 activity in dogs with severe thrombocytopenia and presumed immune thrombocytopenia
… factor cleaving enzyme, is an important cause of thrombocytopenia in immune thrombotic thrombocytopenic purpura (iTTP). This disease can be difficult to differentiate from immune thrombocytopenia (ITP) in people. Further evaluation of other disease entities such as iTTP-like disease is warranted …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
… clinically. This thesis focuses on immune thrombocytopenia (ITP), a disorder marked by immune-mediated platelet destruction and impaired thrombopoiesis. Patients with ITP display heterogeneous clinical trajectories and bleeding severity, often poorly correlated with platelet count, …
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Splenectomy for immune thrombocytopenia : our 11-year experience
… of data on the response rate in HIV-associated thrombocytopenia to splenectomy and the durability of response to splenectomy is unclear in this patient population. We retrospectively analysed 73 consecutive patients who underwent splenectomy for ITP from 2001 to 2011. The primary objective was …
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NEW INSIGHTS INTO THE MOLECULAR PATHOGENESIS OF SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS
Severe Fever with Thrombocytopenia Syndrome (SFTS) virus (also known as Dabie Bandavirus) is an emergent tick-borne Phlebovirus isolated from patients presenting with hemorrhagic manifestations. Case fatality rates range from 12-50%, and over 1 billion people live in regions where the virus is …
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THROMBUS GENERATION UNDER FLOW CONDITIONS IN PATIENTS WITH CIRRHOSIS AND THROMBOCYTOPENIA: THE CIRTAS-STUDY
Background: Thrombocytopenia is a hallmark of cirrhosis, however its effect on the bleeding risk remains uncertain due to a rebalance of hemostasis. Traditional coagulation tests, such as platelet count, prothrombin and activated thromboplastin time, fail to capture the complex interplay of pro- …
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Disease pathogenesis, treatment effectiveness, and co-morbid burden among adult patients with primary immune thrombocytopenia (ITP)
Background Primary immune thrombocytopenia (ITP) is an autoimmune disease involving autoantibody-mediated platelet destruction, suboptimal platelet production, and T-cell-mediated platelet lysis. These processes cause a decreased peripheral blood platelet count (< 150 x 109/L), resulting in an …
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Factors Involved in Health-Related Quality of Life in Children with Immune Thrombocytopenia: A Study from the Dallas ITP Cohort
BACKGROUND: Medication costs and side effects, bleeding severity, and activity restrictions may all play a role in parental/child disease burden in childhood ITP. However, the precise factors involved in health-related quality of life (HRQoL) changes reported by these patients and their families …
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General anaesthesia for caesarean delivery for thrombocytopaenia: findings from an obstetric airway management registry
… In women at risk of spinalepidural hematoma, thrombocytopenia should be excluded. In South Africa, this investigation is often unavailable due to the absence of urgent laboratory services. Methods The obstetric airway management registry (ObAMR) is currently active across all training …
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Study of Physiologic and Immunologic Incompatibilities of Pig to Human Transplantation
… homeostasis incompatibilities leading to acute thrombocytopenia in liver xenotransplantation. Mechanisms for xenogeneic thrombocytopenia were evaluated using liver macrophages, Kupffer cells, leading to identification of CD18, beta-2 integrin, as a potential target for modification. When …
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Comparative study of the clinical manifestations and pathophysiology of leptospirosis and scrub typhus
… aseptic meningitis, jaundice, renal impairment, thrombocytopenia and pulmonary haemorrhage, compared with the culture-negative group. A total of 304 patients were diagnosed as having scrub typhus, one-fourth of who had putative reinfection based on the presence of an IgG response without …
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African trypanosomiasis : its effect on platelet morphology, function and survival
Thrombocytopenia, occurring sometimes in conjunction with disseminated intravascular coagulation, has been reported sporadically in both human and animal trypanosomiases. The extent of the thrombocytopenia and its relationship to the anaemia and parasitaemia has been investigated in experimental …
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USO DA PCR CONVENCIONAL COMO MEIO DE DIAGNÓSTICO DE EHRLICHIA CANIS, ANAPLASMA PLATYS, BABESIA SPP. E HEPATOZOOM SPP. EM CÃES COM TROMBOCITOPENIA
… platys. These diseases are often associated with thrombocytopenia and PCR is a technique with high specificity and sensitivity for the detection of these hemoparasites. The objective of this work was to identify hemoparasites (E. canis, A. platys, Babesia spp. And Hepatozoon spp.) in dogs with …
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Diagnóstico e tratamento de púrpura trombocitopenia imune: uma revisão literária.
The immune thrombocytopenia purpura is a condition characterized by the decreased number of central and peripheral platelets. Is considered benign and self - limiting in most cases and can be classified according to the age , diagnosis, severity and duration of the illness. The clinical appearance …
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Laboratory findings that occur in Klebsiella pneumoniae blood stream infection in HIV-infected children compared to HIV uninfected children, at a South African children's hospital, Cape Town, 2006–2011: a nested-descriptive cross-sectional study
… were observed with leucopenia, neutropenia and thrombocytopenia. Risk of mortality in children with thrombocytopenia at T1 and T2 was aRR 2.5 (95% CI: 1.34-4.64) and 3.18 (95% CI: 1.31-7.73) respectively in the HIV-uninfected group, whereas the risk for mortality in the HIV-infected group with …
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The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa
… systemic lupus erythematosus (SLE) and immune thrombocytopenia purpura (ITP). FcyRHa is therefore a promising target for the development of therapeutics to treat these diseases.
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Structural dynamics and spectroscopic studies of human cytochrome c: Linking dynamics and disease
… activity. Mutations in the Cc gene lead to Thrombocytopenia 4, a disease associated with enhanced apoptotic activity. The Y48H variant is found in the 40-57 W-loop, the lowest free-energy foldon. A 1.36 Å resolution X-ray structure of the Y48H variant reveals minimal structural changes to …
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Subclinical Cytomegalovirus Infection in Neonates: Its Effect on Intellectual and Auditory Functioning.
… Booth, Eleck and Fleck, 1969). In addition, thrombocytopenia, chorioretinitis, pneumonia and diarrhea also may be found (Emmanuel and Kenny, 1966 ; Medearis, 1964, and Weller and Hanshaw, 1962). CMV, when associated with this classical array of symptoms, is referred to as Cytomegalovirus …
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Cytokine receptor-like factor 3 (CRLF3): A novel regulator of platelet biogenesis and potential drug target for thrombocythaemia
… in a range in a range of in vitro assays. The thrombocytopenia is a consequence of abnormalities in hematopoietic cells, as shown by bone marrow transplantations. Megakaryopoiesis is upregulated in Crlf3-/- mice and proplatelet morphology is unaffected, suggesting the thrombocytopenia is due to …
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Cellular regulation of platelet glycoprotein VI : in vivo and in vitro studies in mice
… is associated with a strong, but transient, thrombocytopenia. Using new anti-GPVI mAbs, which bind different epitopes on the receptor, it is shown in this study that GPVI down-regulation occurs in an epitope-independent manner. Further experiments showed that antibody treatment induces a …
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