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Showing 1 to 20 of 20 for “"thrombin generation"”.
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Redox Regulation of Haemostasis; Modulation by Inspiratory Hypoxia and Physical Exercise
… added and the addition of two extra markers of thrombin generation (PF1+2 and T-AT). Data were analysed using a two-factor mixed ANOVA incorporating one between (group: antioxidant intervention vs. placebo control) and one within (condition: time point) subjects factor. Following a significant …
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A Comprehensive Profiling of Hemostatic Activation and Thromboinflammatory Biomarkers and Cellular Indices in Predicting Outcomes in Venous Thromboembolism
… PLR, and SII. Plasma samples were tested for thrombin generation potential, and a comprehensive profiling of hemostatic activation and thromboinflammatory biomarkers using ELISA and biochip array. Statistical analysis included a descriptive test (median with IQR) and a comparative analysis …
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Role of Monocytes and Neutrophils in Thrombosis
… involvement of monocytes and neutrophils in the generation of the potent procoagulant enzyme thrombin was studied. Using a modified thrombin generation assay, it was found that monocytes do not contribute to the activation of thrombin in human plasma under these conditions, whereas neutrophils …
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Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation
… cascade is replaced with a patient-specific thrombin generation curve. This curve is defined by three values obtained from a blood test. Another key feature is the thrombosis growth model, which incorporates conversion of fibrinogen to fibrin, variation between clot core and shell, and …
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THROMBUS GENERATION UNDER FLOW CONDITIONS IN PATIENTS WITH CIRRHOSIS AND THROMBOCYTOPENIA: THE CIRTAS-STUDY
… coagulation tests, such as platelet count, prothrombin and activated thromboplastin time, fail to capture the complex interplay of pro- and anti-hemostatic mechanisms and do not reliably predict the bleeding risk in cirrhosis. Global hemostasis assays, including thromboelastometry and thrombin …
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The Requirement for Viable Platelets in the Coagulation of Heparinized Blood
… takes place. PF3 serves as a surface catalyst, thrombin is generated, and a fibrin clot is formed. The form in which PF3 is available is incidental to clot formation.</p> <p>When heparin is present, however, thrombin is neutralized as fast as it is formed. Quantities sufficient to induce fibrin …
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Flow effect on thrombus formation in stenosed coronary arteries: a computational study
… model for blood coagulation, focusing mainly on thrombin activation, has been formulated in three steps. A phenomenological sub-model for thrombin generation was developed and calibrated, based on clinical tests (not laboratory experiments). The model was proved capable of reproducing with …
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Antithrombotic agents under flow conditions
… has been developed. A method to investigate thrombin generation (TG) in platelet rich defibrinated plasma was validated and used to investigate inhibition by two distinct classes of antithrombotic agents: anti-platelet antibodies and anticoagulants, including unfractionated heparin (UFH), low …
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Computational Modeling And Simulation Of Thrombus Formation
… platelet activation by other agonists besides thrombin and the intrinsic pathway in Chapter 4. An ensemble of probable parameter sets were estimated using nine experimental data sets from a cell-based model and then used to predict the thrombin generation in experiments using patient-derived …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… for complete integrin activation, thromboxane generation and Erk activation. Previous studies have shown that P2Y12 potentiates fibrinogen receptor activation, secretion, thrombi stabilization, thrombin generation, platelet leukocyte aggregation formation. ThromboxaneA2 (TXA2) is a potent …
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¿ROLE OF ENDOTHELIAL DYSFUNCTION IN THE PATHOGENESIS OF UNPROVOKED VENOUS THROMBOEMBOLISM¿
… EC function was assessed by analyzing: a) thrombin generation assessed by TGA on ECs - a modification of Hemker’s method; b) platelet deposition and fibrin formation under flow conditions, assessed in thrombogenesis assay. Assessment of ED role in uVTE pathogenesis. 78 VTE patients and 27 …
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Mesenchymal stem cell therapy for the treatment of myocardial infarction
… was catalytically active, capable of supporting thrombin generation in vitro and enhancing platelet-driven thrombus deposition on collagen under flow. Infusion of MSC via IC route was associated with a decreased coronary flow reserve when delivered but not when coadministered with an antithrombin …
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Thrombosis in Children
… thrombophilia. Also, autoantibodies against prothrombin were significantly more often detected than in controls, suggesting immunological pathogenesis. Pediatric thrombosis often seem to be elicited by a combination of risk factors. Girls receiving high-dose estrogen treatment exhibited both …
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Characterization of OmpT: An outer membrane vesicle protease Escherichia coli that attenuates blood coagulation.
… that upon activation to FVa profoundly enhances thrombin generation and fibrin clot formation as part of prothrombinase. The fibrin clot immobolizes the pathogen and allows the immune system to target and destroy the bacterium. Our research has shown that pathogenic Escherichia coli O86a:K61 …
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Targeting phosphatidylserine exposure in pro-coagulant platelets.
… charged surface. Assembly of the tenase and prothrombinase complexes enhances their activity, increasing thrombin generation. PS is normally confined to the inner leaflet of the plasma membrane by flippase activity, preventing its exposure on the outer surface of unstimulated and pro-aggregatory …
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The Development of a Reduced Order Model for Prediction of Haemodynamic and Biochemical Changes in a Computational Cerebral Aneurysm Thrombosis Model
… The blood was modelled as a Newtonian fluid and thrombin generation curves (TGCs) were used to model the release of thrombin from the injured vessel walls. TGCs representative of haemophiliac, healthy and thrombotic patients were used. Thrombin reacts with fibrinogen to produce fibrin and form a …
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The effects of hypothermia and acidosis on Haemostasis
… STart®4 coagulometer was used to assess the prothrombin time (PT) and the activated partial thromboplastin time (APTT), the ROTEM® analyzer to assess thromboelastometry and the Fluoroscan Ascent to assess thrombin generation using calibrated automated thrombography (CAT). The results show a …
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Clotting analysis of blood samples from intensive care unit patients.
… factors influence coagulation and the rate of thrombin production. The clot stability in intensive care unit samples was found to be more robust in comparison to that observed in the healthy volunteer sample group. This study showed that the initiation of coagulation is delayed intensive care …
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Exploring Anti-FVIII Antibodies in Haemophilia A - Role in In Vitro Haemostasis and Clinical Disease
… plasma from patients with HA. The variation in thrombin production within families was found to be significantly lower than the variation between families, indicating that a familial predisposition may influence thrombin formation in response to by-passing agents (Paper I). Moreover, FVIII …
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GLOBAL COAGULATION ASSAYS AND HEMOPHILIA ARTHROPATHY SCORES FOR MONITORING EMICIZUMAB PROPHYLAXIS IN PATIENTS WITH HEMOPHILIA A
Introduzione: Le terapie non sostitutive stanno emergendo come valido trattamento nei pazienti affetti da emofilia. Tuttavia, nonostante i risultati promettenti, non esiste una tecnica di monitoraggio. La prima terapia non sostitutiva approvata per il trattamento dei pazienti affetti da emofilia A …