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Showing 1 to 20 of 22 for “"thioredoxin reductase"”.

  1. Acetylation regulates Thioredoxin Reductase activity and oligomerization

    WRIGHT, DAVID EThe University of Western Ontario2023

    The Thioredoxin (Trx) system provides the cell with robust defense against oxidative stress and regulates the function of nearly every cellular process through the reduction-oxidation (redox) regulation of proteins. The Trx system is involved in the development of many diseases ranging from cancer …

    uwo Repository record

  2. 자궁내막증 자궁내막에서의 세포증식 증가와 thioredoxin reductase-1 발현의 증가

    박, 재선2011

    … 자궁내막증을 가진 여성의 자궁내막 용종의 발생율 및 세포의 증식도, Bcl-2 단백질과 thioredoxin reductase-1 (TrxR-1)의 발현 정도를 알아보고자 하였다. 연구대상 및 방법 : 복강경과 자궁경을 시행받은 총 631명의 불임 여성 중 자궁내막증을 가진 434명을 실험군으로 자궁내막증이 없는 197명을 대조군으로 하여 자궁내막 용종의 발생율을 조사하였다. 이후 양군에서 얻은 자궁내막조직으로 Ki-67, Bcl-2 단백질과 TrxR-1의 발현을 알아보기 위해 면역조직화학염색법으로 염색한 후 컴퓨터 프로그램 …

    ajou Repository record

  3. Biochemical analysis of a potential drug target in the human protozoal pathogen Trichomonas vaginalis

    Yun, Jeongfill2018

    … enzymes such as pyruvate: ferredoxin oxioreductase and ferredoxin, to treat trichomoniasis caused by T. vaginalis. Recent studies have shown alternative pathways responsible for activating metronidazole without the involvement of hydrogenosomal enzymes. This pathway requires the …

    u-pacific Repository record

  4. Microarray analysis of Trichomonas vaginalis strains T1 and G3: Identifying genes that may contribute to virulence and metronidazole resistance

    Kehoe, Katelin E.2018

    … by Northern Blot analysis. One of these genes, Thioredoxin Reductase (TrxR) was then cloned and transfected into T. vaginalis . After confirming expression of the HA-tagged TrxR, the cell line was then used to determine the effect of over-expression of the gene on drug sensitivity. The …

    u-pacific Repository record

  5. Purification of Global Regulator, Spx, and RNA Polymerase from Staphylococcus aureus for Use in In Vitro Transcription of Redox Genes

    McBride, Jane

    … expression of trxB, the gene encoding thioredoxin reductase, without reducing agents. RNA polymerase was partially purified from S. aureus, and the enzyme was active, catalyzing transcription of rpsD, but not trxB.

    uno Repository record

  6. Selenotrisulfide Derivative Of Alpha-lipoic Acid: Evaluation In A Cell Culture Model For Potential Use As A Topical Antioxidant

    Alonis, Melenie Lee

    … selenoenzymes such as glutathione peroxidase and thioredoxin reductase, and is absolutely required for activity. Thioredoxin reductase is necessary for reduction of oxidized thioredoxin and therefore plays a major role in maintaining the redox status of the cell. Glutathione peroxidase is …

    ucf

  7. A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression

    Rao, AbhilashaUniversity of Illinois at Urbana-Champaign2014

    … including Cu/Zn superoxide dismutase (SOD1), thioredoxin (Trx) and thioredoxin reductase (TrxR). We found that SOD1 interacts with ERalpha, enhances ERalpha-ERE complex formation, influences estrogen responsiveness and associates with estrogen responsive regions of the pS2 and progesterone …

    uiuc Repository record

  8. Characterization of the thioredoxin system in Methanosarcina mazei

    Loganathan, Usha R.Virginia Tech2014

    Thioredoxin (Trx) and thioredoxin reductase (TrxR) along with an electron donor form a thioredoxin system. Such systems are widely distributed among the organisms belonging to the three domains of life. It is one of the major disulfide reducing systems, which provides electrons to several enzymes, …

    vt Repository record

  9. Estado nutricional de iodo, selênio e função tireoidiana em idosos da Universidade Aberta à Terceira Idade

    Santana, Aline dos AnjosUniversidade Federal da Bahia2023

    … the enzyme iodothyronine 5'-deiodinase type I, thioredoxin reductase and selenoproteins. Objective – This study aimed to evaluate the nutritional status of iodine and selenium, through mean urinary concentration and thyroid function, in elderly people enrolled at the Open University of the Third …

    brazil-ufba Repository record

  10. The role of TvTrxR in drug resistance and characterization of TvRad51 in homologous recombination in Trichomonas vaginalis

    Hopper, Melissa2018

    … been found to proceed through inhibition of the thioredoxin-based anti-oxidant pathway, targeting the enzyme thioredoxin reductase (TrxR). In this study, auranofin was found to be an effective inhibitor of T. vaginalis TrxR activity. Auranofin was also found to be an effective inhibitor of …

    u-pacific Repository record

  11. Characterising the response to gliotoxin exposure in Aspergillus fumigatus ΔgliT and ΔgliZ

    Hammel, StephenNational University of Ireland Maynooth2013

    … previous work illustrating the importance of the thioredoxin reductase gliT in self protection against gliotoxin, regulation of which has been shown to be independent of the transcriptional role of gliZ in regulating the cluster. The work presented here characterises the creation of a double gene …

    maynooth Repository record

  12. Translational Frontiers for Chikungunya Virus: New World Epidemic, New Strains, New Therapeutic Targets

    Langsjoen, Rose MartiThe University of Texas Medical Branch at Galveston2020

    … reticulum oxidoreductin-1 (ERO-1) and thioredoxin reductase (TRX-R), respectively, all greatly reduced CHIKV replication in vitro; 16F16 likely caused misfolding of the envelope proteins and subsequent production of non-functional virus particles, while auranofin likely selectively …

    utmb Repository record

  13. Targeting The Redox System to Overcome Mechanisms of Drug Resistance In Chronic Lymphocytic Leukemia

    Ogasawara, Marcia A2014

    … co-culture protection. Increased expression of Thioredoxin Reductase 1 (TxnR1), the target of Auranofin was seen in CLL cells upon stromal co-culture. High apoptotic induction in CLL and minimal cytotoxicity towards stromal cells warrant further examination of Auranofin for CLL therapy. The …

    uthsc Repository record

  14. Charakterisierung der Selenoproteine Thioredoxinreduktase 1 und 2 anhand von Knock-out-Mausmodellen

    Jakupoglu, CemileLudwig-Maximilians-Universität

    Thioredoxin Reductases (TR) are ubiquitously expressed Selenium-containing redox enzymes. By reducing different intracellular substrates they protect cells from oxidative stress. For mus musculus two members of the Thioredoxin Reductase gene family have been characterized so far: TR1 and TR2. …

    lmu-germany Repository record

  15. Discovery and investigation of the novel overall activity allosteric regulation of the Bacillus subtilis class Ib ribonucleotide reductase

    Parker, Mackenzie JamesMassachusetts Institute of Technology2017

    Ribonucleotide reductases (RNRs) catalyze the reduction of nucleotides to 2'-deoxynucleotides in all organisms. Class lb RNRs consist of two subunits: a houses the catalytic and allosteric effector binding sites, and p houses a catalytically essential dimanganic-tyrosyl radical (Mn(III)2-Y*). The …

    mit Repository record

  16. Ribonucleotide reduction and redox regulation in Archaea : surprising twists on a common theme

    Hernandez, Hector HugoMassachusetts Institute of Technology2008

    … (AdoCbl) dependent ribonucleotide reductase (afuRNR) protein. Initial characterization of the recombinant afuRNR indicates that it reduces CDP to dCDP in an AdoCbl dependent manner. One astonishing finding is the capacity of afuRNR to reduce both diphosphate and triphosphate …

    mit Repository record

  17. Mechanistic investigations of class III anaerobic ribonucleotide reductases

    Wei, Yifeng, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2015

    Ribonucleotide reductases (RNRs) catalyze nucleotide reduction via complex radical chemistry, providing deoxynucleotides for DNA synthesis in all domains of life. The focus of this thesis is the class III RNR, found in anaerobic bacteria and archaea, which uses an O₂-sensitive glycyl radical …

    mit Repository record

  18. Differential proteome analysis of human lung epithelial cells following exposure to aromatic volatile organic compounds

    Mörbt, NoraUniversität Potsdam

    … observed at both the reactive centers of thioredoxin reductase 1, which is a key element in the control of the cellular redox state, may be involved in styrene-induced ROS formation and apoptosis. A similar proteomic approach has been carried out with the halobenzenes CB and 1,2-DCB …

    potsdam-diss Repository record

  19. Novel Electron Transfer Systems in Hyperthermophilic Methanogenic and Anaerobic Methanotrophic Archaea: F420-dependent Nitrite Reductase and [Fe-S] Cluster Assembling Thioredoxin

    Heryakusuma, ChristianVirginia Tech2025

    … survival strategies, an F420-dependent sulfite reductase (Fsr), deazaflavin-dependent flavin-containing thioredoxin reductase (DFTR), and a thioredoxin (Trx) homolog with a new function. These proteins are involved in redox reactions, and the research presented here deals with the biochemistry …

    vt Repository record

  20. DNA-Stabilität und Thioredoxin/Thioredoxin Reduktase im Zellkern

    Paunescu, KarinaUniversität Würzburg

    Das System Thioredoxin /Thioredoxin Reduktase(Trx/TrxR) ist ein sehr versatiles System zur neutralisation reaktiver Sauerstoffspezies, zur Regulation redox-sensitiver Vorgänge und zur Aktivierung von Transkriptionsfaktoren wie Steroidhormonrezeptoren, AP-1 und NFkB. Das Enzym Thioredoxin Reduktase …

    wurz-thes Repository record

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