Global ETD Search
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Showing 1 to 13 of 13 for “"thioredoxin (Trx)"”.
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The Thioredoxin Trx-1 Regulates The Major Oxidative Stress Response Transcription Factor, Skn-1, In Caenorhabditis Elegans
… novel mechanism of SKN-1 regulation, in which a thioredoxin, TRX-1, negatively impacts the intestinal subcellular localization of this transcription factor in a cell non-autonomous manner from the ASJ neurons. This function of TRX-1 is specific, as SKN-1 regulation is not a common role for other …
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Oxidative Stress Based Strategies For Enhancing The Efficacy of Histone Deacetylase Inhibitors (Hdaci)
… role of the antioxidants glutathione (GSH) and thioredoxin (Trx). We found that the combination of entinostat-adaphostin induced acetylation of the antioxidant thioredoxin (Trx) and decreased intracellular levels of GSH. However, no effect on Trx activity was observed in either combination. In …
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DNA Repair, Redox Regulation and Modulation of Estrogen Receptor Alpha Mediated Transcription
… proteins Cu/Zn superoxide dismutase (SOD1), thioredoxin (Trx) and protein disulfide isomerase (PDI) are overexpressed in human breast cancer tissues. These studies provide a novel link between DNA repair, redox regulation and modulation of ERalpha-mediated transcription.
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A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression
… including Cu/Zn superoxide dismutase (SOD1), thioredoxin (Trx) and thioredoxin reductase (TrxR). We found that SOD1 interacts with ERalpha, enhances ERalpha-ERE complex formation, influences estrogen responsiveness and associates with estrogen responsive regions of the pS2 and progesterone …
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Expression of Peroxiredoxin Induced by Silica in Alveola Epithelial Cells
… 분화, 세포사멸이나 발암과정에 관여하는 것으로 알려져 있다. 더구나, 이들 Prx 는 thioredoxin (Trx)과 더불어 열충격이나 산화스트레스에 의존적인 분자 생물학적 스위치로서, peroxidase 와 chaperone 기능과의 사이를 조절하는 것으로 알려져 있다. 하지만, 현재까지 폐암을 비롯한 각종 질병에서의 이들 Prx의 역할은 잘 규명되어 있지 않으며, 분해 및 대사과정에 대한 연구는 부족한 실정이다. 이에 본 연구에서는 폐포 상피에서 기원한 폐암세포주인 A549와 WI26에서 실리카 (silica)에 의한 …
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Acetylation regulates Thioredoxin Reductase activity and oligomerization
The Thioredoxin (Trx) system provides the cell with robust defense against oxidative stress and regulates the function of nearly every cellular process through the reduction-oxidation (redox) regulation of proteins. The Trx system is involved in the development of many diseases ranging from cancer …
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Redox Regulation of Type Iα PKA in the Heart
… enhancing their binding. I assessed whether thioredoxin (Trx) redox recycles disulfide RIα back to its reduced state. In adult rat ventricular myocytes (ARVMs) pre-treatment with diamide (inducing disulfide) potentiated isoprenaline-induced cardiac Troponin I phosphorylation. Inhibition of …
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Proteomic Analysis of the Flavonoid Biosynthetic Machinery in Arabidopsis Thaliana
… to detect interacting enzymes. Recombinant thioredoxin (TRX), or TRX-CHI, was produced in E. coli, then purified by metal affinity chromatography, and covalently coupled to an activated resin, Affi-Gel 10. Extracts prepared from 4-day-old wild type or CHI-deficient lines of Arabidopsis were …
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Azione antiossidante del sulforafane: analisi in cellule cardiache in coltura ed in un modello animale di esercizio fisico
… reducing buffer systems including the GSH and thioredoxin (Trx) reductase. GSH is an important tripeptide thiol which in addition to being the substrate for GSTs maintains the cellular oxidation– reduction balance and protects cells against free radical species. Aim of the first part of this …
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Characterization of the thioredoxin system in Methanosarcina mazei
Thioredoxin (Trx) and thioredoxin reductase (TrxR) along with an electron donor form a thioredoxin system. Such systems are widely distributed among the organisms belonging to the three domains of life. It is one of the major disulfide reducing systems, which provides electrons to several enzymes, …
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Analyse der physiologischen Funktion von Mitgliedern der Rieske-Typ Eisen-Schwefel-Proteinfamilie in der inneren Plastidenhülle
… wurden Tic55, PTC52 und PAO als Thioredoxin (Trx)-Targets in der inneren Plastidenhülle identifiziert. Abgesehen von konservierten Rieske- und [2Fe-2S]-Clustern weisen diese Proteine ein CxxC-Motiv auf. Aktivitätsmessungen in An- bzw. Abwesenheit von stromalem Trx f bzw. Trx m …
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Novel Electron Transfer Systems in Hyperthermophilic Methanogenic and Anaerobic Methanotrophic Archaea: F420-dependent Nitrite Reductase and [Fe-S] Cluster Assembling Thioredoxin
… (Fsr), deazaflavin-dependent flavin-containing thioredoxin reductase (DFTR), and a thioredoxin (Trx) homolog with a new function. These proteins are involved in redox reactions, and the research presented here deals with the biochemistry of an Fsr and the Trx homolog. M. jannaschii Fsr (MjFsr) …
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Sulfite reductase and thioredoxin in oxidative stress responses of methanogenic archaea
… cell. Here I focused specifically on the role of thioredoxin (Trx) in methanogens. Trx, a small redox regulatory protein, is ubiquitous in all living cells. In bacteria and eukarya, Trx regulates a wide variety of cellular processes including cell divison, biosynthesis and oxidative stress …