Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 89 for “"thioredoxin"”.
-
DNA-Stabilität und Thioredoxin/Thioredoxin Reduktase im Zellkern
Das System Thioredoxin /Thioredoxin Reduktase(Trx/TrxR) ist ein sehr versatiles System zur neutralisation reaktiver Sauerstoffspezies, zur Regulation redox-sensitiver Vorgänge und zur Aktivierung von Transkriptionsfaktoren wie Steroidhormonrezeptoren, AP-1 und NFkB. Das Enzym Thioredoxin Reduktase …
-
Acetylation regulates Thioredoxin Reductase activity and oligomerization
The Thioredoxin (Trx) system provides the cell with robust defense against oxidative stress and regulates the function of nearly every cellular process through the reduction-oxidation (redox) regulation of proteins. The Trx system is involved in the development of many diseases ranging from cancer …
-
Characterization of the thioredoxin system in Methanosarcina mazei
Thioredoxin (Trx) and thioredoxin reductase (TrxR) along with an electron donor form a thioredoxin system. Such systems are widely distributed among the organisms belonging to the three domains of life. It is one of the major disulfide reducing systems, which provides electrons to several enzymes, …
-
자궁내막증 자궁내막에서의 세포증식 증가와 thioredoxin reductase-1 발현의 증가
… 자궁내막증을 가진 여성의 자궁내막 용종의 발생율 및 세포의 증식도, Bcl-2 단백질과 thioredoxin reductase-1 (TrxR-1)의 발현 정도를 알아보고자 하였다. 연구대상 및 방법 : 복강경과 자궁경을 시행받은 총 631명의 불임 여성 중 자궁내막증을 가진 434명을 실험군으로 자궁내막증이 없는 197명을 대조군으로 하여 자궁내막 용종의 발생율을 조사하였다. 이후 양군에서 얻은 자궁내막조직으로 Ki-67, Bcl-2 단백질과 TrxR-1의 발현을 알아보기 위해 면역조직화학염색법으로 염색한 후 컴퓨터 프로그램 …
-
Sulfite reductase and thioredoxin in oxidative stress responses of methanogenic archaea
… cell. Here I focused specifically on the role of thioredoxin (Trx) in methanogens. Trx, a small redox regulatory protein, is ubiquitous in all living cells. In bacteria and eukarya, Trx regulates a wide variety of cellular processes including cell divison, biosynthesis and oxidative stress …
-
Thioredoxin-mediated reduction of photosynthetic carbon reduction enzymes following chilling in the light
… from both plants was effectively reduced by thioredoxin. The chilling treatment had no effect on the midpoint potential of the regulatory sulfhydryl groups ($-$310 mV), indicating no direct chilling damage to the enzyme. Thiol labeling of FBPase in vivo showed that there was a 60% decrease in …
-
Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway
… followed by mass spectrometric analysis revealed Thioredoxin-1, an essential cytosolic thiol oxidoreductase, to be a potential MLKL regulator. Based on its ability to reduce disulfide bonds on specific protein targets, it was hypothesized that Thioredoxin-1 actively maintains MLKL in a reduced …
-
Mechanism of Light Regulation of Rubisco by Rubisco Activase via Thioredoxin -F in Arabidopsis Thaliana
… incubation of the 46-kDa isoform with DTT and thioredoxin-f increased both activities, whereas incubation with DTT alone or with thioredoxin-m was ineffective. Thioredoxin-f and DTT had no effect on the 43-kDa isoform. However, premixing both soforms before conducting a reduction and oxidation …
-
Expression of Prxiredoxin I, III and Thioredoxin in human lung cancer and the normal lung tissues
… is also found that isoforms of Prx I, III, and thioredoxin are over expressed in the lung cancer tissues when compared to their paired normal control lungs from the same individual. There was also an increased amount of oxidized form of Prx I and a possible truncated form of Prx III in lung …
-
The Thioredoxin Trx-1 Regulates The Major Oxidative Stress Response Transcription Factor, Skn-1, In Caenorhabditis Elegans
… novel mechanism of SKN-1 regulation, in which a thioredoxin, TRX-1, negatively impacts the intestinal subcellular localization of this transcription factor in a cell non-autonomous manner from the ASJ neurons. This function of TRX-1 is specific, as SKN-1 regulation is not a common role for other …
-
Adventitious disulfide bond formation in Escherichia coli and the involvement of thioredoxin and glutaredoxin in suppressing oxidative stress
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
-
Novel Electron Transfer Systems in Hyperthermophilic Methanogenic and Anaerobic Methanotrophic Archaea: F420-dependent Nitrite Reductase and [Fe-S] Cluster Assembling Thioredoxin
… (Fsr), deazaflavin-dependent flavin-containing thioredoxin reductase (DFTR), and a thioredoxin (Trx) homolog with a new function. These proteins are involved in redox reactions, and the research presented here deals with the biochemistry of an Fsr and the Trx homolog. M. jannaschii Fsr (MjFsr) …
-
Insights into structure, dynamics of thioredoxin reassembly and dynein light chain 8 and ionization states of thiamin cofactor by MAS NMR spectroscopy
… and dynamics studies of two proteins, E. coli thioredoxin reassembly and dynein light chain 8 (DLC8) in the solid state are carried out yielding atomic-level details, as discussed in Chapters 2, 3, and 4. Second, ionization and tautomeric states of thiamin diphosphate cofactor (ThDP) in large …
-
Biochemical analysis of a potential drug target in the human protozoal pathogen Trichomonas vaginalis
… This pathway requires the participation of thioredoxin and thioredoxin reductase. These enzymes are essential for T.vaginalis' survival as it is responsible for maintaining cell's redox system, as well as many other cellular processes. Targeting thioredoxin and thioredoxin reductase could be …
-
Etablierung von Mausstämmen defizient für die Selenoproteine mitochondriale Thioredoxin-Reduktase und Phospholipid-Hydroperoxid-Glutathion-Peroxidase (PHGPx) und Charakterisierung einer Spermienkern-spezifischen Form der PHGPx
… ebenfalls Selenocystein-abhängige mitochondriale Thioredoxin/Thioredoxin-Reduktase-System sind bei der Detoxifikation von reaktiven Sauerstoffspezies beteiligt, die in der mitochondrialen Atmungskette erzeugt werden. Im Gegensatz zur PHGPx vermittelt die Thioredoxin- Reduktase ihre Schutzfunktion …
-
Enzyme activities associated with gonadotropic hormones
… amino acid sequences in the active site of thioredoxin and the β-subunit of the gonadotropic hormones luteinizing hormone (LH) and follicle stimulating hormone (FSH), and subsequent demonstration of thioredoxin-like activity associated with these hormones, prompted an investigation into the …
-
Discovery and biological evaluation of ferroptocide
… pro-ferroptotic agents; it is an inhibitor of thioredoxin, a key component of the thioredoxin antioxidant system in the cell. Ferroptocide shows the ability to positively modulate the immune system in a murine model of breast cancer and will be a useful tool to study the utility of …
-
Metabolic Manipulation of Glutathione as an Anticancer Therapeutic Target
… suggests combined inhibition of glutathione and thioredoxin, another intracellular antioxidant, is required for anticancer effects in established tumours. Auranofin is a putative inhibitor of the thioredoxin system. HCT 116 p53-/- cells were resistant to auranofin at doses that HCT 116 p53+/+ …
-
Charakterisierung der Selenoproteine Thioredoxinreduktase 1 und 2 anhand von Knock-out-Mausmodellen
Thioredoxin Reductases (TR) are ubiquitously expressed Selenium-containing redox enzymes. By reducing different intracellular substrates they protect cells from oxidative stress. For mus musculus two members of the Thioredoxin Reductase gene family have been characterized so far: TR1 and TR2. …
-
A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression
… including Cu/Zn superoxide dismutase (SOD1), thioredoxin (Trx) and thioredoxin reductase (TrxR). We found that SOD1 interacts with ERalpha, enhances ERalpha-ERE complex formation, influences estrogen responsiveness and associates with estrogen responsive regions of the pS2 and progesterone …
Page 1 of 5