Global ETD Search
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Showing 1 to 7 of 7 for “"thick ascending limb"”.
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Novel magnesium influx pathways in isolated renal thick ascending limb cells
… magnesium influx pathways in single cortical thick ascending limb (cTAL) cells of the loop of Henle. The segment of thick ascending limb of the Henle's loop plays an important role in renal magnesium homeostasis. Up to 50-60% of the filtered magnesium is reabsorbed in this part and various …
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Regulation Of Nkcc2 Trafficking By Vesicle Fusion Proteins Vamp2 And Vamp3 In The Thick Ascending Limb
<p>The thick ascending limb (TAL) in the kidney regulates extracellular fluid volume and blood pressure. The Na/K/2Cl cotransporter NKCC2 plays a central role in NaCl absorption by the TAL and blood pressure. NKCC2 trafficking to the apical membrane is a major mechanism to control NKCC2 activity. …
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Thick Ascending Limb Nitric Oxide Production And Inhibition Of Nkcc2 Activity Are Impaired In Angiotensin Ii-Induced Hypertension
… important in understanding this pathology. The thick ascending limb (THAL) reabsorbs 30% of the filtered sodium chloride load. Nitric oxide (NO) produced by NO synthase type 3 (NOS3) increases cyclic GMP (cGMP) and inhibits THAL transport by reducing Na/K/2Cl cotransporter type 2 (NKCC2) …
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Modulation Of Renin Secretion By Renal Cortical Interstitial Calcium
… interstitial calcium, and that inhibiting thick ascending limb sodium chloride reabsorption with Furosemide increased PRA without effecting major changes in renal cortical interstitial calcium. Our data support the notion that hypercalcemia inhibits PRA via PTH-mediated increases in renal …
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Understanding Potassium Homeostasis Using Human and Mouse Genetic Models
… and suppresses renal sodium reabsorption in thick ascending limb (TAL). However, the localization and function of KS-WNK1 in TAL are still debatable. Here, I used KS-WNK1 genetic mouse models to demonstrate that KS-WNK1 is present and function to inhibit sodium reabsorption in cortical TAL. …
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The calcineurin inhibitor cyclosporine A activates the renal Na-(K)-Cl cotransporters via local and systemic mechanisms
… (NCC) that are expressed in the thick ascending limb (TAL) and the distal convoluted tubule (DCT) of the nephron, respectively, it has been suggested that the calcineurin phosphatase is involved in the regulation of the salt transporters. Interestingly, previous studies have …
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Bedeutung der Interaktion von Calcineurin und SORLA für die Regulation des Na⁺,K⁺,2Cl⁻-Kotransporters (NKCC2) in der Niere
… Teile der dicken aufsteigenden Henle-Schleife (Thick ascending limb, TAL) und die Macula densa. Resorptiver NaCl-Transport über den NKCC2 dient dem renalen Konzentrierungsmechanismus und reguliert systemisch auch Volumenstatus und Blutdruck. Die Aktivität des NKCC2 ist mit der Phosphorylierung …