Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"thiazole"”.
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Strategies for thiazole/oxazole-modified microcin discovery
… rapidly growing family of natural products, the thiazole/oxazole-modified microcins (TOMMs), and discuss novel methods used to correlate the gene clusters to natural products from this family of metabolites. In chapter 2, I establish the sequence diversity and structural capability of bacteria …
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Synthesis and biophysical evaluation of thiazole orange derivatives as DNA binding ligands
… by G-quadruplex binding ligands such as Thiazole orange (TO). Compared with other G-quadruplex binding ligands, TO has an intriguing tunable fluorescence property. Upon binding to DNA, the fluorescence of TO can increase up to 1000-fold, making it an attractive probe for studying …
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Exploring Prokaryotic Thiamin Biosynthesis: Mechanistic Studies On Thiamin Thiazole Synthase And Pyrimidine Synthase
Thiamin (Vitamin B1) is made from a coupling a thiazole and a pyrimidine unit, which are assembled separately. Studies have shown that the biosyntheses of thiazole and pyrimidine are different in prokaryotes versus eukaryotes. Understanding of thiamin biosynthesis is still incomplete and a lot of …
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Synthesis and biological evaluation of thiazole and metergoline derivatives as antimycobacterial and antiplasmodial agents
… SAR studies were conducted on the 2-amino-4-aryl thiazole scaffold by synthesizing a series of derivatives with different motifs at the various positions of the scaffold. These derivatives exhibited moderate antiplasmodial activity in the CQS strain of P. falciparum, and good antimycobacterial …
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ANTIMICROBIAL CHARACTERIZATION AND THERAPEUTIC APPLICATIONS OF NOVEL SYNTHETIC THIAZOLE COMPOUNDS AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCI AND ENTEROCOCCI
… antibacterial activity of a new series of phenylthiazole antibiotics against a panel of clinically-relevant ‘ESKAPE’ pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). The lead compound 1 was …
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Design, synthesis and characterization of thiazole-based conjugated polymers and their applications to n-channel organic electronics
… solar cells. Among many electron-poor units, thiazoles stand out as a promising building block for high performance organic semiconductors. This dissertation discusses the development of thiazole-based π-conjugated semiconducting polymers to enhance the electron field-effect mobilities by …
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Spécificité mutationnelle du 2-formylamino 4-(5-nitro 2 furyl) thiazole dans le gène lacI d'escherichia coli
Afin de mieux comprendre la spécificité mutationnelle des 5-nitrofuranes, nous avons étudié les mutations induites par le 2-formylamino-4-(5-nitro-2-furyl) thiazol (FANFT), un 5-nitrofurane, dans la région NC+ du gène lacl d’Escherichia coli. Le traitement de la souche TC3960 avec 50 |nM de FANFT …
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On the biosynthesis and discovery of ribosomally synthesized and post-translationally modified peptides
Thiazole/oxazole-modified microcins (TOMMs) comprise a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) that all contain thiazole and oxazole heterocycles derived from cysteine, serine, and threonine residues, respectively. The thiazole/oxazole heterocycle is …
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Synthesis and characterization of Ir(III) metallacycles derived from thiophene and related compounds: models for the hydrodesulfurization process
… (COD=1,5- cyclooctadiene), with thiophene, thiazole, 4-methyl thiazole and 5-methyl thiazole yields the C-S addition metallacycles (Me₃P)₃Ir-(CH=CHCH=S)CI (I), \ (Me3P)3Ir-(CH=NCH=CHS)CI (II), (Me3P)3Ir-CCH=NC(CH3)=CHS)CI (III) and (Me3P)3Ir (CH=NCH=C(CH3)S)CI (IV), respectively. These …
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Mechanistic aspects of thiamine biosynthesis in escherichia coli
… required for the biosynthesis of the thiazole moiety is derived from cleavage of the C??C? bond of tyrosine in a reaction catalysed by the radical S-adenosyl-L-methionine (SAM) enzyme, tyrosine lyase (ThiH). The aromatic by-product of this reaction in vivo was unequivocally …
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Pharmacophore-directed retrosynthesis (PDR) and Density functional theory studies applied to the potent ion channel inhibitor waixenicin A : synthetic studies toward a more stable salarin C congener, thia-salarin C, through the lens of PDR.
… that replacing the endocyclic oxazole with a thiazole would reduce the rate of the Wasserman rearrangement, as previously shown in simpler systems, improving the stability while ideally not altering the potent anticancer activity given the minor change in conformation as determined by DFT. …
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I. A search for organic compounds as colorimetric quantitative reagents for inorganic ions ; II. A study of the reaction between 2 acetamino 6 amino benzo thiazole and chloroiridic acid
The reaction between 2 acetamino 6 amino benzo thiazole and chloroiridio acid is not sensitive enough to be of importance as a colorimetric quantitative reaction. IrCl₆-- can be detected with this organic compound if iridium is present in as much as 0.02 mg. per ml. of solution providing ferric …
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Studies of thiamine biosynthesis
… (Hmp-PP) and 4-methyl-5-(?-hydroxyethyl)thiazole phosphate (Thz-P). The thiazole moiety is biosynthesised from 1-deoxyxylulose-5-phosphate, tyrosine, and cysteine, and at least six genes are required including thiH, thiG, thiS, and thiF. Whilst in aerobes, the C2-N3 fragment of Thz-P …
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Analysis of the effect of various ligands on the hydrolysis of ruthenium (III) complexes and interpretation of kinetics of hydrolysis profiles by UV-visible spectrophotometry
… ligands utilized in this project are imidazole, thiazole, and 1H-1,2,4-triazole. Among these, ruthenium imidazole has passed the Phase I clinical trials. For the ruthenium-imidazole (RIM) complex and the ruthenium-thiazole (RTZ) complex, rates of the hydrolysis reaction are determined by fitting …
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Reactions of 4-chloro-2,6-dimethoxypyrimidine and 2-chlorothiazole with carbanion nucleophiles
… Photostimulated reaction of 2-chlorothiazole (2) with the potassium enolate of pinacolone proceeds by a radical-chain mechanism to give the substitution product resulting from chloride displacement. However, when 2 is allowed to react with pinacolone enolate in the dark a completely …
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NONCOVALENT INTERACTION OF PLATINUM PLANAR AMINE COMPOUNDS WITH TRYPTOPHAN: A STRATEGY TO INTERFERE WITH P53-MDM2 INTERACTIONS AND TARGETING RETROVIRAL ZN FINGER-DNA INTERACTION (HIV NCP7)
… group or extending the π system of pyridine or thiazole by means of a benzene ring (quinoline and benzothiazole) was found to enhance the π-π interaction with N-acetyl tryptophan.</p>
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Metabolic Stability And Pharmacokinetics In Lead Optimization Of Potential Anti-Psychostimulant Pharmacotherapies
… [3-(4-(4-cyclohexylpiperazin-1-yl)butyl)benzo[d]thiazole-2(3h)-thione] a highly selective sigma receptor antagonist using a validated UPLC/MS method. However due to its poor in vivo and in vitro performance further research was halted. Several analogs were then synthesized by blocking the …
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