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Showing 1 to 2 of 2 for “"thiamine metabolism"”.
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Molecular biology of B vitamin metabolism genes and their regulation in Phaeodactylum tricornutum
Thiamine (Vitamin B1) in its diphosphate form is an essential cofactor for virtually all organisms. Thiamine biosynthesis is an expensive metabolic process involving suicidal and low-turnover enzymes, and many organisms have lost the ability to synthesise thiamine and depend on an exogenous source. …
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The Role of Nutrient Availability in Therapeutic Response of Leukemia
… asparagine synthesis. Our approach revealed thiamine pyrophosphate kinase 1 (TPK1), which converts vitamin B1 (thiamine) into the cofactor thiamine pyrophosphate (TPP), as a metabolic dependency under ASNase treatment. In glutamine-anaplerotic leukemia cells, we found that TPP availability …