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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"thiamine"”.
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Studies of thiamine biosynthesis
In Escherichia coli, and other prokaryotes, thiamine (vitamin B1) is assembled by coupling 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate (Hmp-PP) and 4-methyl-5-(?-hydroxyethyl)thiazole phosphate (Thz-P). The thiazole moiety is biosynthesised from 1-deoxyxylulose-5-phosphate, tyrosine, …
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Characterizing Thiamine Status and Mechanisms of Thiamine Supplementation on Subacute Ruminal Acidosis Attenuation in Dairy Cows
… Our teams’ previous research found that thiamine supplementation relieved SARA in dairy cows, but the modes of action of thiamine in SARA attenuation are still unclear. In this context, this thesis was conducted to increase our understanding of relationships between SARA induction and …
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Studies on the biosynthesis of thiamine
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 1959
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Mechanistic aspects of thiamine biosynthesis in escherichia coli
The biosynthesis of the vitamin thiamine is laden with interesting chemistry. In anaerobic bacteria (such as Escherichia coli) a reactive intermediate, dehydroglycine, required for the biosynthesis of the thiazole moiety is derived from cleavage of the C??C? bond of tyrosine in a reaction catalysed …
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Identification and analysis of Arabidopsis thiamine pyrophosphate transporters
Thiamine pyrophosphate (TPP) serves as a cofactor in universal metabolic pathways, including glycolysis, the pentose phosphate pathway (PPP) and the tricarboxylic acid cycle; moreover, it is essential for the proper functioning of all organisms. Recently, several steps of the plant thiamine …
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Interaction between dietary thiamine and lipid in juvenile steelhead trout
Thiamine (vitamin B1) deficiency has been negatively affecting salmonines in the Great Lakes region. This project investigated the hypothesis that thiamine deficiency in steelhead trout is a result of a high lipid diet due to thiamine being used up as an antioxidant to prevent lipid peroxidation. …
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Thiamine deficiency and alcohol exposure both lead to an impulsive phenotype
… the effects of chronic alcohol exposure and thiamine deficiency (or supplementation) in isolation, as well as in concert, to further our understanding of the independent effects of each treatment and how they interact. Our results demonstrated that both chronic alcohol exposure and moderate …
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The design and synthesis of a novel thiamine cofactor for potential biocatalysis
The design and application of enzyme mimics has received more attention due to requirement of green chemistry applications within industry and academia. One way of introducing these modifications is via a cofactor, due to their location within an enzyme’s active site. A number of crucial …
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Structural insights into conformationally-gated reactions catalyzed by thiamine pyrophosphate-dependent enzymes
Thiamine pyrophosphate (TPP)-dependent enzymes utilize TPP as a biological carbanion to initiate reactions on substrates with carbonyl carbon(s), such as pyruvate and 2-oxoglutarate, two central metabolites. This thesis presents structural analyses of three TPP-dependent enzymes. Most …
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A Classical Conditioning Model for Learned Aversions to Tastes Paired With Thiamine Deficiency
Made available in DSpace on 2014-12-10T21:07:27Z (GMT). No. of bitstreams: 1 7212450.pdf: 6181378 bytes, checksum: 90d7a83ece9d80e42b7da75485349db7 (MD5) Previous issue date: 1971
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Studies on the Metabolism of (carbon-14-Labeled)-Thiamine-Hyprochloride in the Rat
Made available in DSpace on 2014-12-05T17:47:18Z (GMT). No. of bitstreams: 1 0009088.pdf: 2555065 bytes, checksum: 6d318d57b31fc21c9c69adfa7b458986 (MD5) Previous issue date: 1954
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Identification and characterization of thiamine biosynthesis, transport, and regulation elements among bacteroides species
Thiamine (vitamin B1) is an essential cofactor for all organisms. Humans primarily acquire thiamine through their diet and thiamine deficiencies have adverse neurological effects. However, the role gut microbes play in modulating thiamine availability is poorly understood. In addition, little is …
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Genetic Engineering of Plant Seeds to Increase Thiamin (Vitamin B1) Content
Thiamine (Vitamin B1) in the form of thiamine pyrophosphate (TPP) is an essential cofactor for the function of numerous enzymes which are involved in central metabolism such as citric acid cycle, pentose phosphate pathway, Calvin cycle, isoprenoid biosynthesis, and branched-chain amino acid …
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Riboflavin and thiamine content of the intestinal tract of cecectomized and non-cecectomized white rats
Thesis (M.S.)--Michigan State College of Agriculture and Applied Science. Dept. of Foods and Nutrition, School of Home Economics, 1949
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Diazepam administration during acute thiamine deficiency attenuates subsequent neuropathology and spatial-memory deficits in rats
Pyrithiamine-induced thiamine deficiency (PTD) in rats causes deficits on a wide variety of spatial-memory tasks. PTD-induced memory deficits are thought to result from damage in areas of the diencephalon that are selectively vulnerable to the metabolic disruption of thiamine deficiency. However, a …
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