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Showing 1 to 2 of 2 for “"thermodynamic determinants"”.
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Analysis of the thermodynamic determinants of protein fold specificity in the denatured state ensemble
Although the thermodynamic control of protein folding has been known for decades, a complete understanding of the thermodynamic determinants that defining protein folds is still elusive. In this regard, it is becoming clear that focusing only on the native states of protein folds will be …
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Ester bond formation in bacterial adhesins
… techniques we explored the steric, chemical, and thermodynamic determinants of bond formation in Cpe0147. Site-directed mutagenesis experiments confirm a serine protease-like mechanism, whereby a histidine abstracts a proton from the bond forming threonine, and a stabilising aspartic acid plays a …