Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 221 for “"therapeutic strategy"”.
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Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Acute Myeloid Leukemia
Inhibition of mitochondrial translation as a therapeutic strategy for acute myeloid leukemia Marko Škrtić Doctor of Philosophy Institute of Medical Science University of Toronto 2012 Abstract Intro: Acute myeloid leukemia (AML) therapies have remained unchanged for 20 years, and thus new therapies …
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Molecular Basis of Prion Pathogenesis and Development of a Novel Therapeutic Strategy
… and more importantly may provide a novel strategy for therapy that is beneficial at the clinical phase of the disease.
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Repurposing itraconazole as a novel and promising therapeutic strategy for pancreatic cancer
… can provide sustainable access to cost-effective therapeutic options for cancer. Accordingly, this thesis has examined repurposing itraconazole, which is an inexpensive and well-tolerated oral antifungal agent currently in use clinically as a novel treatment for pancreatic cancer. We utilised a …
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Intermittent fasting as a therapeutic strategy for alzheimer’s disease: behavioral and molecular evidence
… populations. This dissertation examines IF as a therapeutic strategy for AD, focusing on behavioral parameters and molecular evidence. Chapter 1 provides a thorough review of the current literature from human and animal studies examining the impact of IF on brain health, brain aging, and …
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Modulation of BAZ2 Proteins as a Potential Therapeutic Strategy in Cancer and Neurological Disorders
… prompting us to explore its potential as a therapeutic target. Therefore, we first interfered with BAZ2A pathological functions by hampering through a competitive inhibitor its ability to recognise acetylated lysines (Kac) at the histone tails. Although Kac recognition represents a key BAZ2A …
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Infusing Factor Viii-Expressing Platelets Or Megakaryocytes As A Novel Therapeutic Strategy For Hemophilia A
… this may limit its utility of this strategy. Because of these limitations, we now propose an alternative therapeutic pFVIII strategy of infusing pFVIII-expressing megakaryocytes or platelets. We envision that such a product would be generated beginning with induced-pluripotent stem …
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Biography from childhood to adulthood: mirroring as an educative and therapeutic strategy in caring for carers
… 1971) was effective as an educative and therapeutic strategy for a carer on a one-to-one basis.<br/><br/>Underpinned by humanistic, person-centred principles (Rogers 1951; 1961), fortnightly life review sessions alternated with opportunities for narrative writing during the sixmonth …
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Myc and Cyclin T1 co-expression as a therapeutic strategy for cardiac repair following myocardial infarction
… adult CD1 mice and Lewis rats. Assessment of the therapeutic efficacy of Myc and Ccnt1 co-expression was based on long-term cardiac function studies in the context of both genetic expression as well as acute and delayed treatment with Myc-Ccnt1 mRNA after permanent LAD ligation in mice and rats. …
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The development of a novel therapeutic strategy for the treatment of prostate cancer by targeting metabolic signalling
… resistant prostate cancer (CRPC), for which few therapeutic options exist. Therefore, there is a great need to identify and characterize novel therapeutic targets for this stage of the disease. Cancer cells undergo alterations that allow them to survive and proliferate, and metabolic …
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Mechanistic study on the therapeutic strategy to enhance glioma cell death through inhibition of proteasome and lysosome
… are currently attempting to develop novel therapeutic strategies for malignant gliomas. Recent studies show that dysregulation of protein maintenance has been considerably linked to many diseases. Therefore, protein degradation system has become a platform for drug targeting, and …
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Using pro-vitamin A carotenoids as a therapeutic strategy to reduce the burden of obesity and atherosclerosis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Concomitant Targeting of The Mtor/Mapk Pathways: Novel Therapeutic Strategy In Subsets of Non-Small Cell Lung Cancer
… co-mutational settings, exposing a unique therapeutic vulnerability. Our <em>in vitro</em> and <em>in vivo</em> data testing concomitant pharmacologic inhibition of both pathways (PI3K/AKT/mTOR and MAPK) via AZD2014 (mTORC1/2 inhibitor) and selumetinib (MEK1/2) resulted in synergistic …
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Diagnostic and Therapeutic Strategy in Patients with Pyogenic Liver Abscess // Диагностично-терапевтична стратегия при пациенти с пиогенен чернодробен абсцес
Абсцесът на черния дроб принадлежи към тежките гнойни заболявания и се счита за един от сложните за решаване проблеми на хепатобилиарната система. Честотата на пиогенния чернодробен абсцес (ПЧА) по повод на хепатобилиарна патология по литературни данни е средно от 8 до 16/100000 болни. Основните …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
… CRC mouse models. TASIN-1 may represent a novel therapeutic strategy for colon cancer prevention and intervention.
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
… CRC mouse models. TASIN-1 may represent a novel therapeutic strategy for colon cancer prevention and intervention.
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Inhibition of Vascular Smooth Muscle Cell Migration and Intimal Thickening with Chimeric N-Cadherin Mimetic Peptides: Development of a Novel Therapeutic Strategy for Restenosis
… (EC) death from indiscriminately cytotoxic chemotherapeutic agents. We developed a chimeric peptide with a mimetic domain for neural (N)-cadherin and a matrix- anchoring domain which binds fibronectin that can be delivered to injured blood vessels to inhibit SMC migration while allowing EC …
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Postcholecystectomy Syndrome – an Update of an "Old" Problem. Diagnosis and Modern Therapeutic Strategy // Постхолецистектомичен синдром - актуален поглед върху “стар“ проблем. Диагностика и съвременна терапевтична стратегия
… apply in clinical practice modern diagnostic and therapeutic strategies and treatment methods in patients with PCS in order to optimise outcomes and reduce complications and mortality in operated patients. A retrospective analysis of 1532 patients with GBD and its complications for the period 2011 …
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