Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"therapeutic peptides"”.
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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins
<p>Peptides and proteins are imperative for the human body and play crucial roles in governing various bio-chemical processes. Recent advances in molecular biology and biochemistry helped in understanding the role of these endogenous macromolecules in different pathological and disease conditions. …
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An investigation into the aggregation of therapeutic peptides through adsorption to primary containers
Therapeutic peptides are highly functional drugs currently being investigated for a number of diseases, due to their naturally occurrence in the body, their targeted mechanism and efficacy and tolerability. The four therapeutic peptides under investigation in this thesis; glucagon, liraglutide, …
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Small Therapeutic Peptides: In vitro pharmacokinetics of alpha-carboxyl terminus 11 peptide in rat plasma
… and fail to cure cardiovascular disorders. Small therapeutic peptides are emerging methods to treat diseases ranging from cancer to auto-immune disorders. Due to their nature, they are non-toxic, non-immunogenic, biocompatible and highly target specific. However, because of their small size and …
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Characterization of AG10, a potent stabilizer of transthyretin, and its application in enhancing in vivo half-life of therapeutic peptides
… treatment of these diseases, the development of therapeutic agents that prevent TTR-mediated cardiotoxicity is desired. Here, we report the characterization of AG10 , a potent and selective kinetic stabilizer of TTR. AG10 prevents dissociation of V122I-TTR in serum samples obtained from patients …
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Modeling of Therapeutic Drugs, Polymers, and Self-Assembling Peptides
… groups on designing and testing of new therapeutics and peptide-based materials. In particular, we conducted atomistic molecular dynamics simulations to study systems in three main areas: A) small drugs and therapeutic polymers, B) therapeutic peptides, and C) materials based on …
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One-Carbon Bridge Stapling for use in Peptide-Drug Conjugates
… use in Peptide-Drug Conjugates Bethany M. Cooper Therapeutic peptides lie in between small molecules and therapeutic proteins in terms of their molecular weight and have many advantageous properties, such as high potency and selectivity. Yet one fundamental shortcoming of therapeutic peptides is …
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Studies on the physical stability of a C-terminally amidated variant of GLP-1
… role in the manufacturing and processing of therapeutic peptides. In the process of producing pharmaceutical peptides, molecules are exposed to a wide variety of conditions, some of which enhance aggregation, such as high peptide concentrations. In addition, the long-term physical stability …
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PEGylated Tissue Repair Peptide TP508 Derivatives as Second Generation Drugs for Radiomitigation and Other Systemic Applications
TP508 is a therapeutic peptide that represents a specific receptor-binding domain of human thrombin with many potential clinical applications. However, it shares several weaknesses common to peptides when administered systemically, such as a short circulating half-life and rapid proteolytic …
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Investigation of the Lacticin 481 Synthetase and Its Substrate LctA in the Production of the Antibiotic Lacticin 481
… the enzyme could be utilized to engineer novel therapeutic peptides, further mutational studies were conducted on LctA. Mutation of conserved amino acids within the leader peptide did not abolish LctM activity even though the leader was necessary for full and efficient substrate processing. …
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The development of functionalised stapled peptides as chemical tools to modulate biological processes in platelets and as novel antimicrobial therapeutics targeting Pseudomonas aeruginosa
Peptides are useful modulators of protein-protein interactions (PPIs) and cellular membranes, both of which are traditionally challenging to target using small molecules. Often therapeutic peptides suffer from issues including poor proteolytic stability. Two-component peptide stapling can improve …
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Co-Delivery of Peptide QK and WKYMVm for Minimally Invasive Therapeutic Angiogenesis in Treating Critical Limb Ischemia
… of amputation and mortality. The delivery of therapeutic peptides emerges as a promising alternative, offering the potential to stimulate non-invasive angiogenesis at ischemic sites. However, current delivery platforms still face challenges such as burst release, incomplete delivery, and the …
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Identification and structural bioinformatics of druggable proteins in schistosoma species
… describes the exploration of broad-spectrum therapeutic potentials of Antimicrobial peptides (AMPs) in the design of alternative anti-schistosomal treatment regimen. AMPs are natural antibiotics produced by all living species; they have multifunctional properties and are currently explored as …
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Micro/Nanoencapsulation of Proteins Within Alginate/Chitosan Matrix by Spray Drying
Currently, therapeutic proteins and peptides are delivered subcutaneously, as they are readily denatured in the acidic, protease rich environment of the stomach or gastrointestinal track and low bioavailability results from poor intestinal absorption through the paracellular route. Encapsulation of …
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Role of human β-defensins in human burn wounds
… are a group of recently discovered antimicrobial peptides. The main subtypes include HBD1, 2 and 3 and are individually known to have other functions apart from being anti-microbial. Some of these are inherently expressed while others are induced in response to microbial challenge. Aims - The aim …
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The Development of Methods for Generating Fc-Conjugates and Antibody-Drug Conjugates
Biotherapeutics, such as peptides and proteins, constitute a valuable class of drugs due to their high target specificity and their ability to modulate protein interactions (PPIs), which are often considered ‘undruggable’ by traditional small molecule drugs. Additionally, antibodies possess many …
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Preparation, development and evaluation of novel drug delivery systems for colon targeting
… as potential site for the systemic delivery of therapeutic peptides and proteins. The aim of this work was to develop different colon specific delivery systems by using two model drugs for the treatment of colon diseases: 5-aminosalicylic acid (5-ASA) and metronidazole (MTZ). Two different types …
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Self-assembly of a gonadotropin-releasing hormone antagonist-Teverelix
… for the Pharmaceutical Industry, as many peptides and protein-based drugs have a propensity to self assemble into amorphous or highly structured aggregates. Such processes can occur during the manufacture, purification, processing or even storage of therapeutic peptides, as they are …
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DNA enzymes for tyrosine PEGylation and azido-adenylylation of peptide and protein substrates
… The ability to site-specifically modify peptides and proteins will enable better understanding and applications of these biomolecules. The idea of using DNA enzymes for peptide and protein modification is very attractive, especially considering that DNA enzymes with site selectivity can …
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Exploiting the ‘Complex’ Relationship between Cucurbit[7]uril, Peptides and Gold Nanoparticles for the Development of Biomaterials Suitable for Delivery
… in the formation of materials suitable for therapeutic peptide delivery and diagnostics. Biomedical applications of CB[n] span simple therapeutic complexation leading to increased solubility and circulation times as well as their incorporation into more complex designs. CB[7] exhibits the …