Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"therapeutic drug monitoring"”.
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Development of biosensors for biomarker detection and clinical therapeutic drug monitoring
… remains a gap in the effective diagnosis and the monitoring of diseases to achieve therapeutic success. Current laboratory analysis methods such as mass spectrometry, HPLC and MRI are complex, have high turnaround time, require expertise, are expensive and restricted to laboratory setting. In this …
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The clinical role of therapeutic drug monitoring of antiretrovirals : a Cochrane systematic review
The objective of this study is to evaluate whether ARV TDM reduces mortality and morbidity of adult patients on cART.
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Introducing clinical pharmacology to hepatitis C therapy. Lessons learned from studies on therapeutic drug monitoring and drug-drug interactions
Contains fulltext : 142579.pdf (Publisher’s version ) (Open Access)
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Therapeutic drug monitoring of anti-TNF biologics in patients with Crohn's disease at Groote Schuur Hospital, Cape Town, South Africa
… (UC) and Crohn's disease (CD). The advent of Therapeutic Drug monitoring (TDM) in recent years has allowed further optimisation of their use. TDM involves the measurement of serum trough levels (TLs) and anti-drug antibodies (ADAs), with higher serum drug concentrations and the absence of ADAs …
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Using electronic methods of adherence monitoring and therapeutic drug monitoring (TDM) to eliminate discordance between antiretroviral adherence and virological failure
… to improve outcomes. We explored ideal adherence monitoring methodology for a large public sector ART clinic in Cape Town. Methods: We designed a randomised controlled study for ART-naïve individuals to determine whether text messaging after a missed dose would improve adherence recorded by an …
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Development of novel extraction and separation methods for the determination of anthracyclines and taxanes simultaneously from biological matrices
… to patients and that accurate measurement of drug levels during chemotherapy is proven to be more beneficial to patients, currently no chromatographic method exists for the measurement of any anthracycline and taxane drugs in a single assay. It would be useful to carry out therapeutic drug …
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Optimisation of analytical methods for monitoring monoclonal antibody therapy in Inflammatory Bowel Disease
… Infliximab and adalimumab. However, low drug levels and immunogenicity (development of anti-drug antibodies) are associated with treatment failure. Therapeutic drug monitoring, using drug and anti-drug antibody measurements improves treatment outcomes. This thesis aims to optimise and …
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Innovative analytical methods for Central Nervous System Drug analysis in biological fluids
… number of central nervous system (CNS) drugs have been approved and introduced on the market for the treatment of many psychiatric and neurological disorders, including psychosis, depression, Parkinson disease and epilepsy. Despite the great advancements obtained in the treatment of CNS …
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Quantitation of Anti-Infectious Disease Molecules Utilizing Paper Spray Mass Spectrometry
… agents increases the likelihood of therapeutic failure and resistance. Dosing optimization, while an attractive approach to combat these issues, is difficult to implement due to the different pharmacokinetics of each individual. These limitations highlight the inadequacies of a …
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Development of a HPLC method for the determination of methotrexate (MTX) and MTX-polyglutamates of red blood cells: A dissertation submitted in partial fulfilment of the requirements for the Degree of Bachelor of Science with Honours at Lincoln University
… arthritis (RA). Patient response to, the drug and development of side effects are poorly understood. There is large a variation in clinical response between patients and this influences the dose requirement. Therefore, there is a need for therapeutic drug monitoring to ascertain clinical …
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Determination of total, unbound, and intracellular concentrations of the antiretroviral drugs Efavirenz, Lopinavir, and Ritonavir
… lopinavir, and ritonavir are antiretroviral drugs used for the treatment of HIV in South Africa. Plasma concentrations of these drugs are routinely monitored to ensure efficacy, minimise adverse effects, and adjust dosing. However, variability exists in patient treatment response and …
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Human Genetics, Psychotropic Drugs, and Acts of Violence
… the pharmacological properties of the prescribed drugs or the interaction between the drugs and the enzymes that are primarily responsible for their metabolism (cytochrome P450s) could cause these reactions. Given that acts of violence could be medication-induced, the role of the rate of drug …
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Nonlinear mixed-effects modelling of drug-drug interactions between antiretroviral therapy and tuberculosis treatment
… treatment of HIV and TB often results in drug-drug interactions (DDIs), mediated especially by rifampicin, a key component of the TB regimen and potent enzyme and transporter inducer. These DDIs may compromise treatment safety and efficacy, potentially leading to therapeutic failure and …
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Therapeutisches Drug-Monitoring von Nevirapin : Bedeutung in der Therapie der HIV-Infektion
Nevirapin ist ein Nicht-Nukleosidaler Reverse Transkriptase Inhibitor, welcher seit 1996 in der Therapie der HIV-Infektion eingesetzt wird. Im wissenschaftlichen Labor des Schwerpunktes Hepatologie/Infektiologie der Medizinischen Klinik und Poliklinik II des Universitätsklinikums Würzburg werden im …
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Optimising linezolid use for drug-resistant tuberculosis: pharmacokinetics, toxicity, and resistance
… for more effective, safe, and well-tolerated drugs. Linezolid is a repurposed oxazolidinone antimicrobial with bactericidal activity against M. tuberculosis. Guidelines recommend linezolid as a preferred antituberculosis agent for RR-TB, and it is widely used in national programmes. The major …
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Monitorización farmacoterapéutica de inhibidores de tirosina quinasa en pacientes oncológicos.
… “Monitorización Terapéutica de Fármacos” (TDM, Therapeutic Drug Monitoring). Los inhibidores de tirosin quinasa son fármacos orales administrados a dosis fijas de forma general, además de presentar una alta variabilidad inter e intraindividual debido a sus características farmacocinéticas, por …
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Pharmacokinetic-Pharmacogenetic-and-Pharmacodynamic Adherence Relationships in Cohort South African HIV Infected Children on Lopinavir-and Nevirapine-Based Regimens
… and genetic polymorphism relevant to both drugs Methods: Cox proportional hazard regression modelling for multiple failure events was used to estimate the crude and adjusted hazard effect of lopinavir (Pre-and Post-randomization) and nevirapine(Post-randomization) concentrations and/or …
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Simultaneous quantification of first-line anti-tuberculosis drugs and metabolites in human plasma
… in Africa and Asia (1). Therapy recommended for drug sensitive TB consists of a cocktail of isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (EMB), all given in a 2-month intensive phase, followed by only INH and RIF in a 4-month continuation phase. Clinical studies seeking to …
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Evaluation of adherence to antiretroviral therapy using efarivenz as a marker
… non-adherence may lead to the development of HIV drug resistance, which may lead to virologic failure and treatment failure. Therapeutic drug monitoring (TDM) has been reported to be the most efficient method to assess treatment adherence in HIV individuals, since it quantifies the concentration …
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