Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"theranostic agents"”.
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DEVELOPMENT OF A NANOPARTICLE-BASED PLATFORM FOR THE DELIVERY OF THERANOSTIC AGENTS TO TUMOR TISSUE: TOWARD CLINICAL TRANSLATION
The selective delivery of anticancer agents to tumor tissue remains a major challenge in oncology, as many clinically effective drugs are limited by poor tumor specificity and dose-limiting systemic toxicity. Previous studies from the laboratory have explored the use of tumor-derived and …
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Physical and biological characterisation of clinically relevant combined MRI-radiation exposures with conventional and nanoparticle contrast agents
… provide a unique opportunity for MRI contrast agents to be investigated, not only for the ability to enhance contrast, but for their potential radiosensitising properties to improve radiotherapy treatments. Metal-based nanoparticle contrast agents have a preferential uptake into tumours, …
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Inverted micelles: a novel method of theranostic agent encapsulation for enhanced nano-delivery
… solution for packaging an expansive set of theranostic agents for high-throughput intracellular delivery, which offers numerous advantages over liposomes and other contemporary encapsulation modalities. This encapsulation method works by using a simple 2-step phase-transfer chemistry. The …
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Alchemistic Polymers for the Delivery of Therapeutic Agents in Treatment of Pediatric Tracheomalacia
… such as contrast medium and therapeutic agents. The characterization of these polymers leads to the optimization of a coating platform. Using a factorial design, a library of drug delivery particles for the delivery of an anti-inflammatory agent was generated. The novel polymer containing …
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Synthesis, Characterization, and Evaluation of Novel BODIPY Dyes With Theranostic Applications
… the development of BODIPY based anti-cancer agents and radioimaging dyes has seen little progress. The utilization of fluorescent BODIPYs as photosensitizers for photodynamic therapy, and as boron delivery agents for boron neutron capture therapy offers promise as theranostic agents. …
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Tackling the Bottlenecks in Translational Nanomedicine: Towards Precision in Size Control and Facile Nanoformulation
… vaccines, chemotherapeutics, imaging agents, and theranostic agents.
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Development of Polymeric Nanocarriers for Dual Magnetic Resonance Imaging and Drug Delivery
… these MBIClusters are very sensitive contrast agents. These results indicate that these complexes could be potential theranostic agents for dual imaging and drug delivery. Manganese graft ionomer complexes (MaGICs) comprised of Mn ions and a novel polyaminobisphosphonate-g-PEO copolymer were …
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Amphiphilic hyperbranched polyglycerols for industrial and biomedical applications
… for applications in nanomedicine and industry. Theranostic agents have the potential to provide solutions for the detection, targeting and treatment of cancer and cardiovascular disease, two of the most prevalent medical conditions of developed nations. These agents have been produced from …
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MRI and NMR Investigations of Transport in Soft Materials and Explorations of Electron-Nuclear Interactions for Liquid-State Dynamic Nuclear Polarization
… properties of three different polymeric "theranostic" agents, which combine an imaging functionality on the polymer as well as a DNA/RNA complexation component. These agents are under development to allow real time clinical monitoring of drug delivery and efficacy using MRI. Our NMR method …
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Novel Lanthanide Containing Polymers for Nucleic Acid Delivery and Monitoring of Polyplex Dynamics
… as cancer, heart disease or Alzheimer's disease. Theranostic nanomaterials that combine diagnostic imaging and therapeutic delivery, have potential to minimize the amount of time and dosage required for the treatment. This is achieved via delivery of nanoparticles that carry therapeutic payload as …
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Hepatocellular Carcinoma Image-Guided Intervention: Quantitative Characterization of Reagents For Thermochemical Ablation
… stress in tumor cells. However, these two reagents are not distinguishable from tissues with noninvasive imaging modalities, which makes monitoring the delivery of TCA difficult. Image-guided delivery of TCA can help ensure complete ablation of the tumor and margins for assessment of …