Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"theranostic"”.
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CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
… and intraoperative visualization (termed <em>theranostic)</em> were of focus. Confocal microscopy was employed to characterize<em> in vitro </em>specificity of chlorotoxin, a 4 kDa scorpion venom peptide, and rBSG, the recombinant 25 kDa non-glycosylated extracellular domain of …
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Theranostic applications of fluorescent liquid crystalline nanoparticles
… this direction. One of the most interesting is theranostic, which calls for the design of platforms capable of combining therapeutic and diagnostic functionalities. In this optic, we explored the potential of monoolein-based cubosomes and hexosomes as nanocarriers for theranostic purposes. Our …
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Multifunctional Hybrid Theranostic Nanoplatforms for Cancer Imaging and Therapy
… and applications of multifunctional hybrid theranostic nanoplatforms, integrating imaging and therapeutic capabilities into a single nanoparticle system. The hybrid nanoparticles combine the stability and multifunctionality of inorganic materials with the biocompatibility and degradability …
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OPTIMIZATION OF THE PRODUCTION OF TERBIUM RADIONUCLIDES FOR THERANOSTIC APPLICATIONS
… radioactivity in 1934. Among the developments, theranostics has emerged as a promising approach combining diagnostics and therapy using radiopharmaceuticals labeled with chemically identical radionuclide pairs. In particular, the terbium isotopes 149Tb, 152Tb, 155Tb, and 161Tb have shown great …
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Theranostic nanoparticles for the management of inflammatory diseases and conditions
… benefits. This thesis presents a novel theranostic (therapeutic + diagnostic) nanoparticle platform for the treatment and diagnosis of atherosclerosis. Given the anti-inflammatory effects of statins when cells are directly treated, the aim of this nanoparticle platform was to target …
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Synthesis, Characterization, and Evaluation of Novel BODIPY Dyes With Theranostic Applications
… boron neutron capture therapy offers promise as theranostic agents. Additionally, BODIPY derivatives that absorb and emit in the near-IR regions of the electromagnetic spectrum and bear radioisotopes suitable for radioimaging techniques are of great interest. Chapter 1 is a concise overview of …
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Hybrid Nano-systems Based on PEGylate Porphyrins: Synthesis, Characterization and Theranostic Applications
Following the modern lines of development in theranostic field, this PhD research project focuses mainly on the field of oncological therapies where the primary purpose of the research is to increase the effectiveness of treatments and to decrease the undesirable toxic side effects of current …
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A drug-free theranostic approach for localized and systemic diseases via nanoparticles
… and hence a subfield in nanomedicine called “theranostic” advened in recent years. However, the obstacles in the translation of the nanoparticles such as batch to batch variation during scale-up, the lack of control over cargo release and particle instability slowed their application in real …
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Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer
Nanoparticle mediated photothermal ablation of cancer is a promising technique that utilizes light energy to destroy cancer cells. Specifically, nanoparticles that absorb in the near infrared (NIR) region of light, 700 - 900 nm, are optimal because these wavelengths are an absorption minimum for …
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Inverted micelles: a novel method of theranostic agent encapsulation for enhanced nano-delivery
… solution for packaging an expansive set of theranostic agents for high-throughput intracellular delivery, which offers numerous advantages over liposomes and other contemporary encapsulation modalities. This encapsulation method works by using a simple 2-step phase-transfer chemistry. The …
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Co-opting disease pathology for personalized medicine; utilizing endogenous biomaterials to generate theranostic nanoparticles
… a means for improvement on previous biomimetic theranostics.
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A next generation theranostic nano-platform for sustained and enhanced inhibition of cancer stem cells
Primary tumor extermination and conventional chemotherapy are proved to be inefficient in cancer therapy in that they preferentially abolish differentiated cells whilst leaving behind treatment resistant, tumorigenic cancer stem cells (CSCs). CSCs are validated to be the root cause of therapeutic …
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Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… on a single nanomedicine platform, referred as theranostics. A stable 19F MRI visible nanoemulsion platform was developed, incorporating celecoxib for COX-2 inhibition and near-infrared fluorescent dye(s) for fluorescence imaging. We hypothesized that inhibition of COX-2 in macrophages using a …
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Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… on a single nanomedicine platform, referred as theranostics. A stable 19F MRI visible nanoemulsion platform was developed, incorporating celecoxib for COX-2 inhibition and near-infrared fluorescent dye(s) for fluorescence imaging. We hypothesized that inhibition of COX-2 in macrophages using a …
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THERANOSTIC PLATINUM-BASED COMPLEXES FOR GLIOBLASTOMA TREATMENT AND EVALUATION OF THEIR LOADING AND RELEASE FOR DRUG DELIVERY
Il glioblastoma multiforme (GBM), il tumore al seno triplo negativo (TNBC) e l’adenocarcinoma duttale pancreatico (PDAC) appartengono ad una categoria di tumori conosciuta come tumori orfani. I tumori orfani sono estremamente rari, rappresentano meno dell’1% del numero totale di tumori umani, in …
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Comprehensive integration of safety, optimization, and regulation in ¹⁷⁷Lu-based theranostic radiopharmaceuticals: from production to dose assessment
… cancer diagnosis and treatment. The advent of theranostic radionuclides, enabling both diagnostic and targeted radiotherapy with a single radionuclide, merges two nuclear medicine fields, enhancing personalized targeted radiotherapy through internal dosimetry. Among these agents, the …
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DEVELOPMENT OF A NANOPARTICLE-BASED PLATFORM FOR THE DELIVERY OF THERANOSTIC AGENTS TO TUMOR TISSUE: TOWARD CLINICAL TRANSLATION
The selective delivery of anticancer agents to tumor tissue remains a major challenge in oncology, as many clinically effective drugs are limited by poor tumor specificity and dose-limiting systemic toxicity. Previous studies from the laboratory have explored the use of tumor-derived and …
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Synergistic development of an engineered biodegradable theranostic probe and lymph node organ-on-a-chip to study nanoparticle-lymphatic interactions
… and metastasizes into lymph nodes. Theranostic (therapeutic + diagnostic) nanoparticles have been used in a variety of applications, including the detection and treatment of cancer metastases in lymph nodes. However, accumulation in the liver remains a major concern with any …
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Alchemistic Polymers for the Delivery of Therapeutic Agents in Treatment of Pediatric Tracheomalacia
… blended with preexisting polymers to formulate theranostic nanoparticles for a three month delivery of an anti-inflammatory agent. The optimized polymer platform is synthesized using a contrast medium and an antibiotic to inhibit bacterial infection up to two weeks. Thus the combination of the …
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Hybrid organic-inorganic nanomaterials for applications at the biointerfaces
… years, the application of nanomaterials (NMs) as theranostic devices, which combine diagnostic and therapeutic features, has gained a tremendous interest and development. Still, the major challenge is the understanding of the many and often complex processes that occur during the interaction of …
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