Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"the microfluidic chip"”.
-
Characterization of Mixing in a T-style Microfluidic Chip
<p>The goal of this study is to characterize the mixing that occurs in a microfluidic chip. To characterize the mixing, the minimum length to complete mixing and evolution of mixing will be investigated. There are two types of mixing that occur within a microfluidic channel, diffusion and …
-
Development of a Low Cost Handheld Microfluidic Phosphate Colorimeter for Water Quality Analysis
This thesis describes the design, fabrication, and testing process for a microfluidic phosphate colorimeter utilized for water quality analysis. The device can be powered by, and interfaced for data collection with, a common cell phone or laptop to dramatically reduce costs. Unlike commercially …
-
Transverse Isotachophoresis Using Polyacrylamide Gel Electrodes
… numerous unwanted interfering agents is the first step of nearly every laboratory test performed in medicine and biology. Nucleic acids are often of particular interest to doctors and researchers, and although methods currently exist for their isolation, these procedures are costly in …
-
Loop mediated isothermal amplification based detection of equine respiratory pathogens using a portable, smartphone-based setup
… that impact human and animal health. We report the design, construction, and characterization of a multiplexed platform for multiplexed analysis of disease-specific DNA sequences that utilizes a smartphone camera as the sensor in conjunction with a handheld “cradle” that interfaces the phone …
-
A study of bubble wetting on surfaces
In microfluidics, the formation of bubbles within devices obstructs flow and can damage the microfluidic chip or the samples contained therein. This thesis works toward a better understand of bubble wetting on surfaces, so that future microfluidics devices can be designed to be more robust and free …
-
Microfluidic platforms to evaluate the effects of drugs on fertility and proteins on cancer progression – a focus on cisplatin, alpha-smooth muscle actin, and glial cell line-derived neurotrophic factor
The introduction of in vitro systems that can mimic organ physiology and allow studying the progression of diseases such as cancer is necessary to get reliable information about cell responses and test drug efficacy and toxicity. Classical cell culture systems facilitate a wide range of clinical in …
-
Developing a 3D in vitro Model by Microfluidics
… role in providing a platform that mimics the realistic tissue microenvironment for stimulating and characterizing the cellular behavior. In particular, the hydrogel-based 3D <em>in vitro</em> models allow the cells to grow and interact with their surroundings in all directions, thus better …
-
Evaluating Impact of Endothelial Cells on Drug Response of Lung Cancer Spheroids Using Microfluidic Chip
… resistance continues to be a major limitation in the clinical management of non-small cell lung cancer (NSCLC). While most of the existing research has focused on genetic mutations of tumor cells, increasing attention is being paid to the surrounding tumor microenvironment (TME) as a key factor in …
-
Fabrication of self-assembled zein nanoparticles via microfluidic chip and ultrasonic treatment
There are many health-promoting and disease-preventing bioactive compounds that are beneficial for human health, such as curcumin, lycopene, lutein, resveratrol, and apigenin. However, these bioactive compounds have some challenges to be used in the food and pharmaceutical industries because of …
-
Conformable and robust microfluidic force sensors for orthopaedic surgery
… feedback for orthopaedic surgeons is crucial for the accurate positioning of implants during total hip and knee arthroplasty (THA and TKA respectively). During the trial stage of THA, the surgeon manually determines the implant size, positioning, and range of joint motion of the femoral (ball and …
-
Development of a Multi-Component Biosensor for Recombinase Polymerase Amplification-CRISPR/Cas12a-Based Detection of Fusarium oxysporum f. sp. cubense tropical race 4
… is necessary for effective containment. This thesis explores the development of a multi-component biosensing platform that integrates molecular diagnostics and electrochemical detection for sensitive and portable detection of Foc TR4 DNA. The system combines microneedle-based DNA extraction, …
-
Prominent Platforms for the Synthesis of Size-Controllable Polymeric Nanoparticles for Gene Delivery
Gene therapy, a promising and emerging medical approach, involves delivering exoge- nous DNA or RNA into host cells to manipulate their genetic expression profiles. In cancer treatment, targeting gene therapy offers significant advantages over traditional methods, such as precise control of …
-
Development of a portable microfluidic system for monitoring ions river water
Nowadays, there is a growing demand for predictive models that are capable of predicting future trends in water quality which is constantly being affected by environmental changes and industrialisation. The presence of various nutrient contaminants in surface water poses a serious threat to human …
-
X-ray compatible microfluidic platforms for studying protein structure and function
If you can look into the seeds of time, And say which grain will grow and which will not. - Macbeth. Act I, Scene 3. Knowledge of the three dimensional structure of a protein provides insight into its mechanism, as well as into potential sites for drug targeting. Often these insights provide …
-
Acoustofluidic Innovations for Cellular Processing On-Chip
<p>The advent of increasingly proficient cell handling tools has led to a drastic maturation of our understanding of life on the microscale. Thus far, impressive strides have been made towards creating efficient and compact systems for manipulating cells on-chip. Multiple exciting cell handling …