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Showing 1 to 20 of 27 for “"the heat shock response"”.
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Are thermotolerance and heat acclimation related through the heat shock response?
Thermotolerance (cellular adaptations that allow survival after an acute, severe heat exposure) and heat acclimation (systemic adaptations that improve heat dissipation following chronic heat exposure) have traditionally been considered separate phenomena. However, recent studies in animals suggest …
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Regulation of The Heat Shock Response By Thiol-Reactive Compounds In The Yeast Saccharomyces Cerevisiae
<p>Cells govern their activities and modulate their interactions with the environment to achieve homeostasis. The heat shock response (HSR) is one of the most well studied fundamental cellular responses to environmental and physiological challenges, resulting in rapid synthesis of heat shock …
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Coordination Between Autophagy and the Heat Shock Response: Evidence From Exercise in Animals and Humans
… health and homeostasis often hinges on the ability of intracellular regulatory systems to sustain the quality and function of these diverse, structurally complex macromolecules. Correct protein function depends on correct form, and during periods of destabilizing cellular stress, protein …
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The heat shock response in embryonic and young of the year juvenile round whitefish (prosopium cylindraceum)
I investigated the effects of acute, increased temperatures on round whitefish embryos at the protruding mouth stage and young-of-the-year (YOY) juveniles at 3.5 months post hatch by characterizing the kinetics of the heat shock response (HSR). The HSR provides protection from a variety of …
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The impact of acute heat exposure on the heat shock response (HSR) between males and females
While acute heat stress induces genomic changes in immune cells of young adults, the influence of ovarian hormones on the molecular response remains unclear, despite their documented role in thermoregulation. This study investigated the molecular response to acute heat stress in males (n=11), …
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The heat-shock response in <i>Serpula s</i>pecies at the cellular and molecular level
The study focuses on the effects of heat stress on <i>Serpula lacrymans</i> and <i>S. himantioides</i> (which have been previously shown to be relatively thermosensitive and thermotolerant respectively) in relation to the heat shock response. A part of this response is the production of heat-shock …
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Plasticity of the heat shock response and development of thermotolerance during embryonic development of Lake Whitefish (Coregonus clupeaformis)
Thermal discharge produced by industrial facilities has the potential to impact development of fish by increasing background temperature of the surrounding area. The overall objectives of this study were to: 1) Examine the interplay between how temperature and frequency of heat shock and post-heat …
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The Pursuit of Unshocking Hsp90 Inhibitors: Development of Gedunin and Cruentaren A as Chemical Leads
Abstract: The 90 kDa heat shock protein (Hsp90) is a molecular chaperone that is critical cellular survival and growth under both typical and stressful conditions. Hsp90 is responsible for the maturation and stability of more than 200 client proteins involved in a diverse assortment of cellular …
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REDOX PROTEOMICS, THIOL HOMEOSTASIS AND NEUROPHYSIOLOGICAL CORRELATIONS IN AGING AND NEURODEGENERATION
The terms "aging" and "neurodegeneration" are often used in a broad and generalized manner. Actually, they are particularly complex and multifaceted processes, involving different biochemical systems. Increasing evidence supports the notion that reduction of cellular expression and activity of …
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Assessing The Therapeutic Viability of Hsc70 in ALS
… neurodegenerative disease, characterized by the denervation of the neuromuscular junction and death of motor neurons. When cells face stressful insult the heat shock response is activated in an attempt to reduce intracellular calamity. The heat shock response is identified by the increased …
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Inducción térmica del inicio de la replicación cromosómica en Escherichia coli
A shift-up of ten or more degrees in the growth temperature of an Escherichia coli culture causes induction of extra rounds of chromosome replication. This heat-induced replication (HIR) initiates at oriC, is transitory, requires RNase H1 and RecA and requires neither RNA polymerase activity nor de …
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Redox Sensing By Yeast Hsp70 Facilitates Modulation of Protein Quality Control and The Cytoprotective Response
… diseases. One factor linked to formation of these aggregates is damage sustained to proteins by oxidative stress. Cellular protein homeostasis (proteostasis) relies on the ubiquitous Hsp70 chaperone family. Hsp70 activity has been previously shown to be modulated by modification of two key …
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Stress response of porphyromonas gingivalis
The heat shock response of Porphyromonas gingivalis was examined by one-and two-dimensional polyacrylamide gel electrophoresis after metabolic labeling with (14C)-amino acids. When P. gingivalis cells were shifted from 37°C to 42°C, elevated synthesis of four proteins with the apparent molecular …
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Mechanisms Underlying The Heterogeneous Sensitivities of Cancer Cells to Proteasome Inhibitors
<p>The mechanisms underlying cellular response to proteasome inhibitors have not been clearly elucidated in solid tumor models. Evidence suggests that the ability of a cell to manage the amount of proteotoxic stress following proteasome inhibition dictates survival. In this study using the …
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Discovery of heat shock protein90 inhibitors using structured-based virtual screening
Alzheimer's disease (AD) is the most common irreversible dementia, caused by accumulation of protein aggregates in the central nervous system, with symptoms that include memory loss and behavioural abnormalities. Cholinesterase inhibitors (ChEIs) and N-methyl-D-aspartate receptor (NMDAR) …
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Autophagy During and Following Dynamic Exercise in Young Adults: Influence of Exercise Intensity
Autophagy plays a critical role in the cell’s response to exercise-induced cell stress. Exercise intensity and elevations in tissue temperature are known to modulate autophagic activation, however, the relationship is still unclear. Thus, we investigated the effect of increasing intensities of …
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Thiol-Based Misfolding: Linking Redox Balance to Cytosolic Proteostasis
<p>The eukaryotic cytosolic proteome is vulnerable to changes in proteostatic and redox balance caused by temperature, pH, oxidants and xenobiotics. Cysteine-containing proteins are especially at risk as the thiol side chain is subject to oxidation, adduction and chelation by thiol-reactive …
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Neuronal Protection by a Novel C-terminal Hsp90 Modulator
… and aggregated proteins, indicating that the protein quality control machinery is compromised. Enhancing the activity of molecular chaperones such as the `heat shock' proteins (Hsp's) that re-fold or signal degradation of damaged proteins may help remove protein oligomers/aggregates and …
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Leveraging HSF1 chemical-genetic tools to elucidate mechanisms of proteostasis
… and trafficking mechanisms collectively termed the proteostasis network. This network assists folding and maintains optimal protein localization and concentration. While the components and organization of this network are generally well-established, our understanding of how protein folding …
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Bistability, Synthetic Biology, and Antibiotic Treatment
<p>Bistable switches are commonly observed in the regulation of critical processes such as cell cycles and differentiation. The switches possess two fundamental properties: memory and bimodality. Once switched ON, the switches can remember their ON state despite a drastic drop in stimulus levels. …
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