Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"the common marmoset"”.
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String-Pulling by the Common Marmoset
… routinely perform complex motor tasks with their hands. This thesis develops a string-pulling task to investigate skilled motor control in the common marmoset (Callithrix jacchus). In the first study, we analyzed 15 marmosets of varying ages in their home cages using single-camera markerless …
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Modelling the Neuropsychopharmacology of Obsessive-Compulsive Disorder in the Common Marmoset (Callithrix jacchus)
This thesis extends the understanding of the neural and neurochemical contributions to two forms of behavioural adaptation, reversal learning and contingency degradation, in which stimulus/action–reward contingencies are altered. The results are interpreted within the psychological framework of the …
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Studies of immune biology of the common marmoset: a novel non-human primate transplant model.
… anti-donor immunity and immune tolerance. DC are therefore an important target for potential tolerance-inducing therapies, which must be validated in non-human primate models before clinical trials. The common marmoset is a small, New World primate which our group is developing as a novel …
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Characterising trait anxiety in the common marmoset (Callithrix jacchus): investigations into behavioural, psychophysiological and cognitive phenotypes
The major aim of my thesis project has been to develop a non-human primate model of trait anxiety, using a new world monkey, the common marmoset. The first step was to identify animals high or low in trait anxiety. Based on the findings that high trait-anxious individuals display …
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Differential contributions of subregions of the dorsal anterior cingulate cortex to negative emotion in the common marmoset
The dorsal anterior cingulate cortex (dACC) has been implicated in a broad range of cognitive and emotional functions, including the processing of negative emotion. Furthermore, abnormalities in dACC activity have been associated with anxiety and depression, disorders in which negative emotion is …
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Finding Common Ground: The Common Marmoset as a Model to Accessing and Providing Insight into the Social Brain
<p>Utilizing the immense strengths of the common marmoset (Callithrix jacchus) as a model organism, we executed three efforts with the common goal of revealing key insights into dissecting the social brain. First, we examined the hypothesis that there is a neural, functional architecture underlying …
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Examining the role of the anterior and posterior orbitofrontal cortex in emotional regulation in the common marmoset (Callithrix jacchus)
The dysfunction and structural abnormalities of the orbitofrontal cortex have been reported in a number of affective disorders, including depression and several anxiety disorders. However, research has largely centred around reward-guided decision-making and economic choice, as opposed to how it …
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Computed tomography of the thorax and abdomen of the clinically normal common marmoset (Callithrix jacchus)
The aim of this study was: 1) to describe the computed tomographic thoracic and abdominal anatomy in the clinically normal common marmoset; 2) to describe the normal reference range of Hounsfield units (HU) of major abdominal and thoracic organs; 3) to refine the computed tomography (CT) protocol; …
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A Behavioral Study on the Adult Marmoset Interference Control in Spatial Working Memory
… is associated with neurodevelopmental disorders. The common marmoset (Callithrix jacchus) is an ideal non-human animal model for studying WM disorders. Previous studies of marmoset WM have used a touch-screen self-ordered sequencing task (SOST), which resembles an n-back paradigm and targets …
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Transcriptomic Signatures of Projection Class Neurons for Vocal Control
<p>Vocal learning is the ability to modify acoustic structure and syntax of vocalizations. This rare trait is thought to have independently evolved three times in birds and five times in mammals. Vocal learning species exhibit an underlying convergence in brain circuitry, including a direct, …
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Serotonin and Threat: from Gene to Behaviour
… depression and anxiety disorders. This raises the question: why are some more vulnerable to experiencing negative emotions associated with threat than others? As serotonin has been implicated as a key neuromodulator of emotion, the thesis addresses this question by adopting a multi-systems …
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Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease
… (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that is a leading non-traumatic cause of disability in young adults. The 18 kDa Translocator Protein (TSPO) is a mitochondrial protein and positron emission tomography (PET)-imaging target that is highly upregulated …
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The role of ventrolateral prefrontal cortex in performance of spatial self-ordered response sequences in the marmoset
The ventrolateral prefrontal cortex (vlPFC) in primates plays an important role in cognitive control and working memory, but as argued in the Introduction its contribution to those aspects of goal-directed behaviour such as planning and executing spatial response sequences requires further …
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The role of frontal-striatal circuits in instrumental behaviour
… and it can be habitual, whereby a stimulus in the environment can trigger a response regardless of the outcome. Behavioural output can be a mixture of goal-directed and habitual aspects and there may be a competitive balance between these dual influences. Degrading contingencies between actions …
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Trophoblast specification and differentiation potential in early human and non-human primate embryogenesis
Implantation is mediated by trophoblast, the outer layer of the early embryo. Trophoblast is an extraembryonic tissue that gives rise to the placenta, which sustains fetal growth and development. Human embryo implantation and early trophoblast development have remained elusive due to the …
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The role of ventromedial and dorsolateral prefrontal cortex in physiological and behavioural dysfunction in non-human primates, of relevance to mood and anxiety disorders
The research presented in this thesis investigates the causal role of area 25 of the subcallosal anterior cingulate cortex and area 46 of the dorsolateral prefrontal (dlPFC) cortex in depression- and anxiety-like behaviour in a non-human primate, the common marmoset. Depressed patients show …
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Marmoset emotional regulation during adolescence and adulthood, with a particular focus on risk-taking and the role of the subgenual anterior cingulate cortex in motivation and affective biases
… in exploratory behaviour and risk-taking. These behavioural and neurobiological changes are particularly evident in primates, where social groups and relationships are complex, and maturation of the prefrontal cortex (PFC) is prolonged, lasting from childhood into early adulthood. The PFC …