Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"the RNA recognition motif"”.
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Investigation of the interactions in RNA recognition motif-RNA complexes: small molecule inhibitors and kinetics of dissociation
The RNA recognition motif (RRM) is the most abundant RNA binding domain that is found in all organisms. RRM-containing proteins participate in most steps of gene expression, including translation, splicing, modification and transport of RNA. This dissertation aims to help understand the …
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Investigation of the dynamics and conformational changes of the U1A protein
The U1A-SL2 RNA complex is a model system for studying interactions between RNA and the RNA recognition motif (RRM), which is one of the most common RNA binding domains. Despite extensive studies conducted to study the origins of U1A-RNA affinity and specificity, little is known about the kinetics …
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Mechanisms of Human LARP6 Nuclear Export
The La Related Protein 6 (LARP6) regulates the expression of type I collagen synthesis by binding to the encoding mRNA. However, the molecular mechanism of ligand binding and cellular localization is not fully understood. Understanding the mechanisms of LARP6 regulation requires knowledge of where …
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Exploring Protein -Rna Interactions With Site-Directed Mutagenesis and Phage Display
"The importance of RNA as a mediator of genetic information is widely appreciated. RNA molecules also participate in the regulation of various post-transcriptional activities, such as mRNA splicing, editing, RNA stability and transport. Their regulatory roles for these activities are highly …
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Exploring Protein-Rna Interactions With Site-Directed Mutagenesis and Phage Display
The importance of RNA as a mediator of genetic information is widely appreciated. RNA molecules also participate in the regulation of various post-transcriptional activities, such as mRNA splicing, editing, RNA stability and transport. Their regulatory roles for these activities are highly …
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Exploring protein-RNA interactions with site-directed mutagenesis and phage display
The importance of RNA as a mediator of genetic information is widely appreciated. RNA molecules also participate in the regulation of various post-transcriptional activities, such as mRNA splicing, editing, RNA stability and transport. Their regulatory roles for these activities are highly …
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Characterization of the Association of mRNA Export Factor Yra1 with the C-terminal Domain of RNA Polymerase II in vivo and in vitro
<p>The unique C-terminal domain (CTD) of RNA polymerase II (RNAPII), composed of tandem heptad repeats of the consensus sequence YSPTSPS, is subject to differential phosphorylation throughout the transcription cycle. Several RNA processing factors have been shown to bind the appropriately …
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Effects of BRCA1-Mediated Ubiquitination of HuR on RNA Metabolism in Breast Cancer
<p>BRCA1, a gene encoding for the tumor suppressor protein BRCA1, is involved in DNA repair as well as many other important cellular processes. BRCA1, together with BARD1 (BRCA1 Associated RING Domain 1) also functions as an E3 ubiquitin (Ub) ligase. BRCA1 mutation in the RING domain, which is …
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Molecular and functional characterisation of circadian clock regulated RNA-binding proteins from Arabidopsis thaliana
The clock-regulated small RNA-binding protein AtGRP7 (Arabidopsis thaliana glycinerich RNA-binding protein) influences its own circadian oscillations by negative autoregulation at the post-transcriptional level, presumably by binding to its own transcript. The present work analyses the RNA-binding …