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Showing 1 to 10 of 10 for “"thalamic reticular nucleus"”.
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Single-cell transcriptomics of the mouse thalamic reticular nucleus
The thalamic reticular nucleus (TRN) is strategically located at the interface between the cortex and the thalamus, and plays a key role in regulating thalamo-cortical interactions. Current understanding of TRN neurobiology has been limited due to the lack of a comprehensive survey of TRN …
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Cellular and Circuit Properties of Slow Oscillations In The Thalamic Reticular Nucleus
<p>During sleep, neurons in the thalamic reticular nucleus (TRN) generate distinct types of oscillatory activity. While the reciprocal synaptic circuits between TRN and sensory thalamic nuclei underlie the generation of sleep spindles, the mechanisms regulating slow (<1 >Hz) forms of thalamic …
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Causal control of the thalamic reticular nucleus using optogenetic and novel chemogenetic approaches
… A key 'guardian' of the gate may be the thalamic reticular nucleus (TRN). The TRN is a primary source of GABAergic input to thalamic relay nuclei. The TRN projects directly to the rest of thalamus, generating feedforward and feedback inhibition. It is therefore positioned to mediate …
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Auditory Processing Deficits in MSH2-KO mice are linked to Aberrant Inhibitory Neuron Function in the Thalamic Reticular Nucleus
… observed a significant decrease in cortical and thalamic cfos expression in <em>Msh2<sup>-/</sup></em><sup>-</sup> mice, indicating a reduction in neural activity compared to WT littermates. To examine possible mechanisms underlying this hypoactivity, we focused on the thalamic reticular nucleus …
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Targeting NMDA Receptors to Tune Corticothalamic Circuit Function
The somatosensory corticothalamic (CT) circuit processes ascending sensory signals, and disruption to the balance of excitation and inhibition (E/I) within CT circuitry leads to absence seizures, sleep disorders, and attention deficits. E/I balance may be restored by independently modulating …
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Biophysical model of core & matrix thalamocortical circuitry in rodents & primates
… between the cortex, thalamus and inhibitory thalamic reticular nucleus compose the thalamocortical system that is responsible for sensory processing and attention, during wakeful states, and sleep spindle generation, during sleep states. The TC system is divided into two sub-circuits, the …
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Brain states and circuit mechanisms underlying sleep and general anesthesia
… I then demonstrate that activation of the thalamic reticular nucleus generates slow wave activity and decreases arousal state, identifying a causal mechanism that generates physiological and behavioral signs of sleep. Finally, I study patients undergoing deep general anesthesia at levels …
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Cortico-thalamic interactions for head direction coding
… areas, the hippocampal formation, and diverse thalamic nuclei. Of these, the anterodorsal thalamus (ADn) is the major avenue by which HD is routed to cortex. In other cortical areas, cortico-thalamic loops have been shown to perform transformations on incoming sensory inputs for learning and …
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Neuronal Nicotinic Receptor Dynamics in Medial Geniculate Body Neurons of Young and Aged Fischer Brown Norway Rats
The medial geniculate body (MGB) is the thalamic nucleus situated between the inferior colliculus (IC) and auditory cortex (AC) in the ascending auditory pathway. It has classically been thought of as a relay station for auditory stimuli; however, we now know that is capable of significantly …
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Dendritic properties of inhibitory thalamic neurons: implications in sub-cortical sensory processing
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2014-06-28T10:00:20Z Item was in collections: Graduate Theses and Dissertations at Illinois (ID: 204) Neuroscience Program Dissertations (ID: 630) No. of bitstreams: 2 Crandall_Shane.pdf: 5543535 bytes, checksum: …