Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"tetrazole"”.
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In vitro metabolism of tetrazole aminoquinolines and derivatives of metergoline and fusidic acid
… during the early development of aminoquinoline tetrazoles, and derivatives of metergoline and fusidic acid as potential antiplasmodial and/or antimycobacterial agents.
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The Solid State Simulation of the Structure and Vibrational Modes of Organic, Hybrid Organometallic and Inorganic Species Using the CRYSTAL09 Code.
… three studies involving the use of 5-(4-pyridyl)tetrazole, and lastly (3) the crystal structure and simulation of α,α,α’,α’-tetrabromo-p-xylene. The studies involving 5-(4-pyridyl)tetrazole are comprised of (a) the comparison of a new polymorph to previously published crystallographic information …
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Synthesis and Coordination Studies of Novel Heteroaryl Tetrazoles
… studies of an array of heteroaryl 5-substituted tetrazole ligands. A family of 5-substituted pyridyl tetrazole ligands with various functionalities tethered to the tetrazole moiety were prepared and fully characterised. These ligands were reacted with various MX2 salts (M = Cu, Ni, Co, Zn; X = …
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Towards the synthesis of hyacinthacines
… with benzaldehyde using (S)-5-pyrrolidin-2-yl-1H-tetrazole as organocatalyst is described and it results in the formation of the dehydrated aldol adduct in moderate selectivity. The organocatalytic aldol reaction of CS and C2V-symmetrical dioxanones is also demonstrated and in most cases …
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Design, Synthesis and Evaluation of Organic and Metal Based Antimicrobial Agents
… well-known carboxylic acid bioisostere, the (1H)-tetrazole, and (2) a hydroxamic acid. Both the (1H)-tetrazole and hydroxamic acid derivatives were found to exhibit bacteriostatic activity similar to that of their carboxylic acid analogues. Finally, the synthesis of a family of dioganotin(IV) …
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Synthesis and characterization of diverse copper halide complexes with a range of heterocyclic ligands
… and 5-(4-chlorophenyl)-1H-tetrazole. The second utilized Cu(CH3CN) with mixed ligands specifically 3,5-diphenolpyrazole and pyrazine, as well as 3,5-(tert)-butylpyrazole and pyrazine. Complex synthesis occurred via solvent-mediated routes using the Schlenk technique and …
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The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents
… to design NCEs based on quinoline-, PA-824-, and tetrazole-scaffolds, which exhibit in vitro antiplasmodial and antimycobacterial activity.
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1,3-Disubstituted-tetrahydro-β-carbolines: A New Method for Stereochemical Assignment and Synthesis of Potential Antimalarial Agents
… bioavailability profile. The total synthesis of tetrazole (trans-23a) and phosphonic acid ((±)-62a) derivatives of 1a is discussed in detail. The tetrazole analog 23a was previously synthesized in the Carlier group as a diastereomeric mixture of cis and trans isomers (dr = 3:7), and it was tested …
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Sintesi di molecole organiche enantiomericamente arricchite con l'uso della catalisi organica
… catalysts, for example L-proline, L-pyrrolidine tetrazole and so on. This is important because is necessary to found news synthetic methods to produce pyridines nucleus that are very important building block for drugs. Following it is illustrated a preliminary result of a new methodological …
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New methodology for the organocatalysed α-Amination reaction
… agent and (S)-(-)-5-(2-pyrrolidinyl)-1H-tetrazole as the preferred organocatalyst. The desired aminated products were obtained in high yields and enantioselectivities. The reaction showed broad substrates cope in its application to ketals, dioxolanes and lactols. A hydrazide N-N bond …
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On the design and further applications of iridium (I) complexes in hydrogen isotope exchange processes
… of a novel method for ortho-HIE in unprotected tetrazoles under basic conditions, revealing a rare account of N-H tetrazole C-H activation and a new mode of reactivity for Kerr group HIE catalysts. Towards predictive catalyst design, a combined experimental and theoretical model has been …
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An excursion into the synthesis of novel flavanones
… returned the aldol product using (S)- proline tetrazole as organocatalyst. Several experiments on optimization were conducted to identify the best stoichiometry/conditions as ketone (4): aldehyde (1): catalyst (10%): DMSO (2): H2O (2) at room temperature for three days, which returned the …
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An Investigation into Clinically Relevant Determinants of Azole Resistance in Candida albicans
… of our clinical collection to the new tetrazole antifungals VT-1161 and VT-1598, which have been reported to exhibit potent activity against azole-resistant C. albicans and a host of other fungal species. We additionally investigated determinants of resistance to the two new agents by …