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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 24 for “"tetratricopeptide"”.

  1. Understanding tetratricopeptide repeats of <i>O</i>-GlcNAc transferase

    Gundogdu, MehmetUniversity of Dundee2017

    … factor-1 (HCF-1). OGT contains an N-terminal tetratricopeptide repeat (TPR) domain, with some evidence to suggest that this domain plays a role in substrate and adaptor protein binding. However, our understanding of the mechanisms underlying OGT substrate recognition and specificity remains …

    dundee Repository record

  2. Tetratricopeptide 39C (TTC39C) Is Upregulated During Skeletal Muscle Atrophy and is Necessary for Muscle Cell Differentiation

    Hayes, Caleb, Hayes, Caleb Stevenson, 1989-University of North Florida. Department of Biology

    unf Repository record

  3. The Interplay of RSV and IFITs: A comprehensive analysis of human and bovine Interferon-Induced Proteins with Tetratricopeptide Repeats induction and interaction with human and bovine Respiratory Syncytial Virus

    Varga, MichalUniversity of Cambridge2024

    The interferon-induced proteins with tetratricopeptide repeats (IFITs) are early-response antiviral proteins conserved across vertebrates. Following stimulation of cells, they are amongst the most highly induced genes, although the patterns of induction kinetics of individual IFIT proteins are …

    cambridge Repository record

  4. Crosstalk of TTC5 cofactor and the estrogen receptor in breast cancer

    Ashtiani, F2026

    … motifs, interacts with cofactorssuch as TTC5 (tetratricopeptide repeat domain 5) which is a 440 amino acid protein,predicted to have 6 TPR (tetratricopeptide repeat) motifs and 4 LXXLL motifs, which areknown to mediate protein-protein interactions. TTC5 has been shown previously tointeract with …

    salford Repository record

  5. A study on human IFIT3 modulation of IFIT1 protein stability

    Leong, Xin YunUniversity of Cambridge2021

    Interferon-induced proteins with tetratricopeptide repeats (IFITs) are expressed in both interferon-dependent and interferon-independent manners in cells after pathogen-associated molecular pattern recognition by the pathogen recognition receptors. Four IFITs (IFIT1, IFIT2, IFIT3 and IFIT5) have …

    cambridge Repository record

  6. Biochemical and Structural Studies of the Role of FKBP(L)s in the fly and Mammalian Circadian Cycle

    Agyekum, Kwaku BoadiUniversity of Missouri -- Kansas City2017

    … domain that interacts with DOUBLETIME and tetratricopeptide repeats at its C-terminal region that may mediate protein-protein interaction. We used similar techniques to identify BDBT vertebrate functional homologues FKBP51, FKBP52 and FKBPL. In vitro kinase assays showed that all three …

    umkc Repository record

  7. EXAMINING THE ROLE OF THE XAB2 PROTEIN IN HOMOLOGOUS RECOMBINATION

    Neherin, Kashfia2015

    … HDR and SSA events. XAB2 protein contains 15 tetratricopeptide repeat (TPR) motifs, which likely enable protein-protein interactions. While XAB2 is speculated to have a role in transcription coupled repair and pre-mRNA splicing, its role in HR pathway is uncertain. The overall hypothesis for …

    csusb Repository record

  8. Mutationsanalyse des intraflagellaren Transportprotein-Gens hTg737 bei Patienten mit Situsanomalien und hereditären Nierenerkrankungen

    Greiner, Eva Judith

    … eine Größe von 833 AS und weist 10 Kopien eines Tetratricopeptide Repeats (TPR) auf. Es existieren zwei Mausmodelle mit Defekten in Tg737. Mäuse, die homozygot für die Insertionsmutation Tg737orpk sind, weisen renale und hepatische Fehlbildungen sowie Skelettanomalien und einen Hydrocephalus auf. …

    freiburg-diss Repository record

  9. Characterisation of the plasmodium falciparum HSP70-HSP90 organising protein

    Gitau, Grace WairimuUniversity of Zululand2014

    … Structural domains and motifs such as the tetratricopeptide repeat (TPR) that are conserved across Hop homologues were identified in the PfHop. Data suggested that PfHop is a canonical Hop homologue of the P. falciparum. Recombinant PfHop was heterologously expressed in Escherichia coli (E. …

    zulu Repository record

  10. Structural Insights into the Mechanisms Controlling the Modification and the Readout of Histone H3.1

    Davarinejad, HosseinUniversité d'Ottawa / University of Ottawa2023

    … understood. In this work, we characterized the tetratricopeptide repeat (TPR) domain of TONSOKU (TSK), a DNA damage response protein, as a variant-specific reader for histone H3.1 and established a role for H3.1 in replication-coupled DNA repair via the homologous recombination pathway. Using …

    ottawa-retro Repository record

  11. Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins

    Madden, Sarah KayUniversity of Cambridge2019

    … discovery. The properties of consensus-designed tetratricopeptide repeat proteins (CTPRs) make them very amenable to be rationally-designed into potential new PPI inhibitors. This study sets out to investigate whether this could be achieved through the grafting of binding peptides into the …

    cambridge Repository record

  12. Post-translational regulation of BiP by FICD-mediated AMPylation and deAMPylation

    Perera, Luke AUniversity of Cambridge2021

    … — ATP-bound, domain-docked BiP — with FICD’s tetratricopeptide repeat domain binding a tripartite assembly of BiP’s nucleotide binding domain, docked linker and substrate binding domain, that is unique to the aforementioned Hsp70-state. My studies also shed light on the structural basis of the …

    cambridge Repository record

  13. Engineering mono- and multi-valent inhibitors on a modular repeat-protein scaffold to target oncogenic Tankyrase

    Diamante, AuroraUniversity of Cambridge2020

    … properties. One such repeat motif, the tetratricopeptide repeat (TPR), has already been exploited for biotechnological applications and here the consensus-designed TPR (CTPR) sequence was used as a scaffold to create novel arrays of binding molecules. The platform allows us to display …

    cambridge Repository record

  14. Demonstration of Interactions Among Dif Proteins and the Identification of Kapb as a Regulator of Exopolysaccharide in Myxococcus Xanthus

    Li, ZhuoVirginia Tech2007

    … pathway in M. xanthus. In addition, KapB, a TPR (Tetratricopeptide repeats) protein, was identified as an interacting partner of DifE byY2H library screening. Further analysis demonstrated that the N-terminal half of KapB interacted with the putative P2 domain of DifE. KapB had been previously …

    vt Repository record

  15. Structural Insights into Modification and Export of the Pseudomonas aeruginosa Alginate Exopolysaccharide

    Gheorghita, Andreea Alexandra2023

    … via the outer membrane porin AlgE and the tetratricopeptide repeat-containing protein AlgK. We elucidated the crystal structure of the AlgKX complex and showed that AlgK, AlgX, and the AlgKX complex are capable of binding alginate polymer. In P. aeruginosa, disruption of the AlgKX complex …

    toronto-retro Repository record

  16. Identification of Phosphorylase Kinase Alpha Subunit Binding Partners in Skeletal Muscle

    Archila, Soleil

    … The remaining 5 clones were identified as tetratricopeptide repeat protein 1 (TPR1). TPR1 is an adaptor protein that functions in a wide array of cellular processes and is considered a highly specific adaptor. The results reported herein are intriguing given that PhK is associated with the …

    wku-diss Repository record

  17. Construction and Biological Characterisation of Custom Engineered Protein Degradation Tools.

    Stockton, SianUniversity of Cambridge2022

    … of different AurA- and E3-binding sequences: tetratricopeptide repeats (TPRs), RAD protein, and monobodies. The structures, stabilities and binding of the grafted scaffolds were investigated. Characterisation included circular dichroism spectroscopy to ensure correct folding and thermal and …

    cambridge Repository record

  18. Engineering Synthetic Biomolecular Condensates with Rationally-Designed Modular Repeat Proteins

    Ng, Tin Long ChrisUniversity of Cambridge2025

    … of synthetic condensates based on consensus tetratricopeptide repeat (CTPR) proteins, modular folded non-globular domains, fused with low-complexity domains (LCDs), intrinsically disordered domains that drive phase separation. By systematically engineering a library of LCD-CTPR constructs …

    cambridge Repository record

  19. Strengths and Weaknesses of Hybrid TPR Technology for Obtaining Structural and Mechanistic Insights into TPR Proteins

    Yu, Shanshan2016

    <p>Tetratricopeptide (TPR) repeats are a 34-residue helix-turn-helix motif that when repeated pack into a superhelical structure. TPR domains are frequently found mediating protein-protein interactions, often through a central groove. One protein complex bearing numerous TPR repeats is the Anaphase …

    tenn-hsc Repository record

  20. Molecular pathways controlling DNA damage response

    Alhebshi, H2026

    … has been the focus of intense research. TTC5 (Tetratricopeptide repeat domain 5) or STRAP was identified as p53 cofactor and a key component of the p300/CBP (CREBB binding protein) complex. TTC5 enhances the interaction of JMY (Junction mediating and regulatory protein, p53 co- factor) and …

    salford Repository record

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