Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"tetrasaccharide"”.
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I. Microwave-Influenced Diversity-Oriented Synthesis Of Biologically Relevant Small & Natural-Product-Like Molecules Via Multicomponent Coupling Reactions Ii. Synthetic Studies Toward The Total Synthesis Of The Repeating Tetrasaccharide Unit Of Zwitterionic Polysaccharide Ps A1
… the total synthesis of the repeating tetrasaccharide unit of zwitterionic polysaccharide PS A1 using different strategies. PS A1 is known to modulate T-cell response via MHC-II pathway and shown to prevent tumor growth. The synthesis is quite challenging and we have been able to …
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Fluorous assisted one-pot oligosaccharide synthesis and chemical synthesis of homogeneous heparan sulfate proteoglycan
… product is achieved. A trisaccharide and a tetrasaccharide are synthesized using this method. Hpearan sulfate proteoglycans (HSPGs), including syndecans and glypicans, are ubiquitous components of mammalian cell surface and extracellular matrix and they play important roles in various …
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Structure and Metabolism of Heparin and Heparan Sulfate
… products, primarily disaccharides and tetrasaccharides, were then end-labeled by reduction with sodium borotritide and purified to homogeneity using a combination of BioGel P-2 chromatography and strong anion exchange HPLC. The unknown components of both the disaccharide and …
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Structural analysis of capsular polysaccharides produced by some emerging Klebsiella pneumoniae serotypes
… three uronic acids and is made up of a tetrasaccharide backbone chain with two terminal monosaccharide residues, thus a 4 + 1 + 1 RU type. In contrast, KL107 CPS was found to be identical to serotype K2, having a tetrasaccharide RU, with a trisaccharide backbone chain and a single …
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I. Sulfonium-Mediated Oxidative Glycosylation of Glycal Donors for the Synthesis of C(2)-Hydroxy-Beta-Glycosides. II. Hypervalent Iodine (iii)-Mediated Oxidative Glycosylation of Glycal Donors for the Synthesis of C(2)-Acyloxy-Beta-Glycosides. III. Efforts Toward the Synthesis of Immunologic Adjuvant Qs-21a(api)
… the saponin, which includes a trisaccharide, a tetrasaccharide, a triterpene and an acyl side chain were accomplished leading to the assembly of these four components to provide the fully protected QS-21Aapi.
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Chemical aspects of some ovine hepatogenous photosensitization diseases
… 2121 and 557 mg/kg respectively). The furostenol tetrasaccharide, (25R/S)-furost-5-ene-3β,22α,26-triol 3-O-{O-α-L-rhamnopyranosyl-(1→2)-O-[O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranosyl}-26-O-β-D-glucopyranoside, was isolated from a USA collection of P. virgatum. …
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Toward the automated synthesis of carbohydrates and glycosaminoglycans
… and the proteoglycan linkage region tetrasaccharide were synthesized in a fully automated fashion. The efforts towards the synthesis of two glycosaminoglycans - hyaluronic acid and chondroitin sulfate - are discussed. The work focuses on the discovery of a glycosylating agent suitable …
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Monosialylgangliosides from human meconium: characterization using specific anti-oligosaccharide antibodies
… antibodies. Structural analyses of two sialyl[³H]tetrasaccharide alditols obtained in this way were carried out with sequential enzymatic degradation using specific exoglycosidases. The products of enzymatic digestions were identified by cochromatography in paper with known standards. Data …
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Synthesis of Novel Antimycobacterials and a Fluorescent Sensor for Simple Carbohydrates
… compounds. A mannose containing tetrasaccharide from the mannan core of lipoarabinomannan (LAM) of Mycobacterium tuberculosis has been synthesized using α-D-methylmannopyranoside as starting material and Koeings-Knorr reactions to couple saccharides. The synthesis was completed in …
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Detection of colorectal carcinoma-associated antigens using specific antibodies against human milk oligosaccharides
Rabbit antibodies against human milk sialyltetrasaccharide b Galßl—3[NeuAca2—6]GlcNAcßl—3Galßl—4Glc) and sialyltetrasaccharide a (NeuAca2-3Ga|ßl·3GlcNAcß1-3Galßl-4Glc) were used to detect their homologous haptens as gangliosides in the human colorectal carcinoma cell line SW'lll6. …
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Synthesis And Á-Stereoselective Sialylation Of Kdn And Late Stage Modification Of Neuraminic Acid Sialosides
… of a neuraminic acid containing branched tetrasaccharide to a KDN containg tetrasaccharide as well as to a number of other systems.</p>
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Solution and solid-phase synthesis of potential carbohydrate vaccines for leishmaniasis and malaria
… by host macrophages. The synthesis of a unique tetrasaccharide found on the parasite cell surface lipophosphoglycan is described. The synthetic material was used to create two novel immungens that are currently being evaluated in an animal model. New methods were also developed for an automated …
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Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)
… the aberrant enrichment of a unique sulfated tetrasaccharide (Tetra-1) in PDAC tissues from KRAS<sup>G12D</sup>-driven PDAC genetically engineered mice model but not in healthy pancreas from WT-KRAS mice. HS3ST1, a gene encoding for a sulfotransferase enzyme responsible for the synthesis of …
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Structural studies on enzymes involved in uronic acid polysaccharide degradation
… However, the complex structure with the bound tetrasaccharide substrate reveals the difference in the active site and mode of substrate cleavage. Overall, the structures determined as part of this research provide structural templates for a large number of lyases classified into the four …
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MOLECULAR MODELING STUDIES OF HEPARIN AND HEPARIN MIMETICS BINDING TO COAGULATION PROTEINS
… Using in-silico docking techniques, selected tetrasaccharide sequences were found to specifically recognize this triad of amino acids indicating the possibility of specific recognition of thrombin. This hypothesis led to the design of a putative lead sequence that is 50% smaller in size and …
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Biophysical chemistry of lipopolysaccharide specific bacteriophages
… three Salmonella enterica hosts is built from tetrasaccharide repeating units consisting of an identical main chain with a distinguished 3,6 dideoxyhexose substituent that is crucial for P22 tailspike recognition: tyvelose in S. Enteritidis, abequose in S. Typhimurium and paratose in S. …