Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"tetraploidy"”.
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Telomere-Driven Tetraploidy and its Relevance to Cancer
… the telomeric proteins POT1a and POT1b leads to tetraploidy in p53/Rb de cient mouse cells. Irreversible telomere deprotection and other forms of persistent DNA damage induce a prolonged G2 phase followed by by-pass of mitosis, re-entry into S phase, and whole genome reduplication. …
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The effects of chromosome number changes on mitotic fidelity and karyotype stability
… found in certain normal tissues and organisms, tetraploidy (four sets of chromosomes) is associated with a number of precancerous lesions and is believed to promote aneuploidy and tumorigenesis. While it is clear that chromosome mis-segregation causes aneuploidy, the effect of aneuploidy on …
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Increased levels of ploidy in A. texanum-dependent A. platineum (JJL) populations in eastern Illinois: conservation implications for the state endangered species
… host instead and has had persistent levels of tetraploidy. This has been shown to be a result of the fertilization of unreduced A. platinuem ova by Ambystoma texanum sperm (JJLTx). More recently at least 6 other A. texanum-dependent A. platineum populations have been discovered in Vermillion …
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The evolution of centrosome and chromosome number in newly formed tetraploid human cells
Tetraploidy – the presence of four copies of the haploid chromosome complement – is common in cancer. There is evidence that ~40% of tumors pass through a tetraploid stage at some point during their development, and tetraploid cells injected in mice are more tumorigenic than their diploid …
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The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway.
… overexpressed it can bypass senescence and the tetraploidy checkpoints that protect against cancer. When the current study was initiated it was unclear as to whether the endogenous overexpression of TBX2 was a cause or consequence of the oncogenic process and whether it may be a suitable …
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Cytogenetics and genome structure in genus Miscanthus, a potential source of bioenergy feedstocks
… the genus Miscanthus experienced an ancestral tetraploidy and chromosome fusion prior to its diversification, but after its divergence from the closely related sugarcane clade. The genetic map for Miscanthus is useful in biological discovery and breeding efforts to improve this emerging biofuel …
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Linkage mapping in tetraploid blackberry (Rubus spp.) using high-throughput genomic sequencing and restriction-site associated DNA sequencing (RAD-seq)
Genomic molecular marker research and linkage mapping in cultivated polyploid species of Rubus, in particular blackberry, has lagged behind diploid members of the genus due to the complex analyses required to deduce allele dosage among homologous and homeologous chromosomes. Traditional techniques …