Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"tetramic acids"”.
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Total synthesis of naturally occurring glycosylated tetramic acids
… first synthesis of a naturally occurring 3-acyl tetramic acid glycoconjugate was investigated. An endofungal metabolite called epicoccamide D was synthesized for the first time. This was accomplished in 19 steps resulting in a 17% overall yield. The total synthesis was built on a modular base to …
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Synthesis and Evaluation of Tetramic Acids as Antimicrobial Agents
… exhibiting antimicrobial activity possess a tetramic acid (2,4-pyrrolidinedione) functional group. As their antibacterial mechanism of action is different from that of many of the currently available antibiotics, these compounds have potential to serve as a basis for a pharmacophore in …
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The Design and Synthesis of β-Keto Vinyl Sultams and Macrocyclic β-Keto Vinyl Sultams: Novel Analogs of Tetramic Acids
… Similarly, natural products possessing the tetramic acid core structural motif have emerged as a rich chemotype due to their potent and broad biological activities. Several bioactive tetramic acid-containing compounds have been reported with a variety of activities, including antibacterial, …
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Molecular Recognition of Nucleic Acids
… was unsuccessful. Friedlander condensation with tetramic acids was shown to be a viable method for construction of the tricyclic portion of a CG host.
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Towards the Synthesis of Magnesidin
… chelate of the 3-hexanoyl and 3-octanoyl tetramic acid derivatives isolated from <em>Psuedomonas magensiorubra</em>. Its activity against grampositive bacteria was found to be a specific target for Gingivitis, a dental plaque.Although the synthesis of magnesidin has been reported earlier, …
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Synthesis and Spectroscopic Study of Anticancer agent A-007 Prodrugs and Progress Towards the Synthesis of Tetramic acid Antibiotics
… prodrugs are presented in this dissertation. Tetramic acid (2, 4 pyrrolidine-2, 4-dione ring system) containing compounds have been found to display a remarkable diversity of biological activities and have attracted the interest of medicinal and synthetic chemists. Magnesidin …