Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"tetramic"”.
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Total synthesis of naturally occurring glycosylated tetramic acids
… first synthesis of a naturally occurring 3-acyl tetramic acid glycoconjugate was investigated. An endofungal metabolite called epicoccamide D was synthesized for the first time. This was accomplished in 19 steps resulting in a 17% overall yield. The total synthesis was built on a modular base to …
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Synthesis and Evaluation of Tetramic Acids as Antimicrobial Agents
… exhibiting antimicrobial activity possess a tetramic acid (2,4-pyrrolidinedione) functional group. As their antibacterial mechanism of action is different from that of many of the currently available antibiotics, these compounds have potential to serve as a basis for a pharmacophore in …
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Keteneylidenetriphenylphosphorane as a 'C2O building block' in the synthesis of highly functionalised tetramic and tetronic acids
Naturally occurring 4-hydroxy-pyrrol-2(5H)-ones and 4-hydroxy-furan-2(5H)-ones are known to possess a wide range of biological activities such as anti-viral and tumour inhibition. For this reason, the synthesis of a number of these compounds was attempted, namely Tenuazonic Acid, Reutericyclin and …
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The Design and Synthesis of β-Keto Vinyl Sultams and Macrocyclic β-Keto Vinyl Sultams: Novel Analogs of Tetramic Acids
… Similarly, natural products possessing the tetramic acid core structural motif have emerged as a rich chemotype due to their potent and broad biological activities. Several bioactive tetramic acid-containing compounds have been reported with a variety of activities, including antibacterial, …
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Synthesis and Spectroscopic Study of Anticancer agent A-007 Prodrugs and Progress Towards the Synthesis of Tetramic acid Antibiotics
… prodrugs are presented in this dissertation. Tetramic acid (2, 4 pyrrolidine-2, 4-dione ring system) containing compounds have been found to display a remarkable diversity of biological activities and have attracted the interest of medicinal and synthetic chemists. Magnesidin …
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Syntheses of natural bioactive 3-acyltetramic acids and derivatives
… the side chain). Therefore, a L tyrosine derived tetramic acid was coupled to different side chains, which were synthesised separately, by applying varying 3 acylation conditions. Macroetherification via palladium catalysis and subsequent deprotection provided the desired macrocycles. The second …
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Molecular Recognition of Nucleic Acids
… was unsuccessful. Friedlander condensation with tetramic acids was shown to be a viable method for construction of the tricyclic portion of a CG host.
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Development And Applications Of Thioacids In Peptide Chemistry And Exploration Of Methods Toward The Stereochemical Elucidation And Synthesis Of Virgineone
… section of chapter one reviews the importance of tetramic acid containing natural products, and the various methods for their formation, and continues with an overview of stereoselective methods for â-mannosylation, such as are required for the total synthesis of virgineone, a novel glycosylated …
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Towards the Synthesis of Magnesidin
… chelate of the 3-hexanoyl and 3-octanoyl tetramic acid derivatives isolated from <em>Psuedomonas magensiorubra</em>. Its activity against grampositive bacteria was found to be a specific target for Gingivitis, a dental plaque.Although the synthesis of magnesidin has been reported earlier, …
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Protective effect of dietary antioxidants and plant extracts on acute inflammation and hepatotoxicity in vitro
… may also play a vital role on stabilizing the tetramic structure of TTR and thereby prevent amyloidosis diseases. Lipoic acid represents in this study unique function against inflammation and hepatotoxicity. Despite the protective effect demonstrated by investigated substances, attention should …
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The Design and Synthesis of Novel Antimicrobial Agents for Use in the Battle Against Bacterial Resistance
<p>There is an ever increasing need to develop new antimicrobial agents with novel mechanisms of action. These new agents will help to combat the steady rise of antibiotic-resistant bacteria which are becoming more and more difficult to treat due to the dwindling number of antibiotics available to …