Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"tetramerization"”.
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Selectivity in subunit composition of EnaNASP tetramers
… ability to form tetramers via a highly conserved tetramerization domain located at the Cterminus of all EnaNASP proteins. The potential formation of mixed tetramers may combine the unique aspects of each paralog into one molecule. Here, I describe a series of immunoprecipitation experiments to …
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Characterization in cochlea of KCTD12/PFET1, an intronless gene with predominant fetal expression
… fetal expression containing a single tetramerization domain (PFET1, HUGO-approved symbol KCTD]2) was identified from the Morton fetal cochlear cDNA library. KCTD12/Kctd]2 is an evolutionarily conserved intronless gene encoding a 6 kb transcript in human and three transcripts of …
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A biophysical and biochemical approach to understanding the interplay between Quaternary structure and function of human calprotectin
… consequences of Ca(II) binding and tetramerization. We found that the heterotetramer exhibited significant resistance to enzymatic proteolysis compared to the heterodimer. Using NMR spectroscopy, we observed that the dynamics of CP change significantly upon Ca(II) binding small, yet …
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Circadian Control of Cell Cycle Progression
… p53 from binding to DNA. This implies that the tetramerization of p53 may also be another factor in Per2's ability to bind to p53. A truncated p53 lacking the last 30 amino acids that theoretically increase p53's ability to form a tetramer showed a drastic reduction in binding to Per2 5, 6. On …
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Mechanisms of Telomere End Protection by TRF2
… formed by regions in its Hinge and Myb domains. Tetramerization is necessary for t-loop formation by TRF2, as a TRF2 mutant lacking part of its second dimerization domain properly localizes to telomeres but is deficient in suppressing ATM and cNHEJ. The ability of this mutant to suppress ATM and …
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Synthesis of symmetric and asymmetric water-soluble porphyrin derivatives
… confirmed by NMR and X-Ray crystallography. Tetramerization of excess butanopyrrole and several aldehydes also afforded novel metallo-butanocorroles and metallo-benzocorrole. The structures of these compounds are also analysed using MS (MALDI), NMR and X-Ray crystallography.
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A. Discovery of novel reactivity under the Sonogashira reaction conditions B. Synthesis of functionalized BODIPYs and BODIPY-sugar conjugates
… terminal alkynes underwent self-trimerization or tetramerization. In an alternative approach to access substituted enediynes, treatment of alkynes with trisubstituted (Z)-bromoalkenyl-pinacolboronates under Sonogashira coupling conditions was found to give 1,2,4,6-tetrasubstituted benzenes instead …
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P53 Dimers Elicit Unique Tumor Suppressive Activities Through An Altered Metabolic Program
… transcription factor, mutation of the p53 Tetramerization Domain (TD) is a mechanism by which cancers abrogate wild-type (WT) p53 function. p53 TD mutations result in a protein that preferentially forms monomers or dimers. These are also normal p53 states under basal cellular conditions. …
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The Challenge of Selectivity in Ethylene Oligomerization: Ligand Design and Metal Valence States
… Commercial systems producing selective tri/tetramerization, non-selective oligomerization and polymerization are all based on this metal with the exception of a few systems based on other transition metals (Zr, Ti, Ni etc.). This versatility raises interesting questions about chromium’s …
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Genetic exploration of exercise associated sudden death in racehorses
… genes, aquaporin 4 (AQP4) and potassium channel tetramerization domain containing 1 (KCTD1) on the region in chromosome 8, showed potential relevance to dysrhythmia development. Specific Aim 2: This study aimed to identify causative variants in arrhythmogenic candidate genes for EASD in …
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Cardiac Calsequestrin Phosphorylation And Trafficking In The Mammalian Cardiomyocyte
… for CSQ2. The fusion protein exhibited a tetramerization-dependent trafficking predicted to be very similar to CSQ2 polymerization-dependent trafficking with high and low secretory compartment Ca2+ concentrations leading to polymerization and monomerization, respectively. </p> <p> </p> …
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Determination of fatty acid synthesis intermediates in escherichia coli and bacillus subtilis
… identified interactions within the dimerization/tetramerization interface that compensate for each other and showed that the wildtype FabG predominantly exists as a dimer but functions as a tetramer. The mutation also rendered the enzyme extremely sensitive to calcium in vitro and conferred …
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Making Molecular Movies: Using Single-Molecule Techniques to Unveil Hidden Features of Protein-Chromatin Interactions
… They have also shown that its helicase and tetramerization activities are dependent on an intact C-terminal domain (CTD), which are all required to confer mycobacterial resistance; however, the mechanisms behind the CTD and what its role is in resistance had remained unknown. We used smCFFM …