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Showing 1 to 20 of 134 for “"tetramer"”.
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Characterisation of the (H3-H4)2-tetramer and its interaction with histone chaperones
… the field: the structure of the soluble (H3-H4)2-tetramer, and the conformation of H3 and H4 in complex with histone chaperones.Firstly, we determined the conformation of histones H3 and H4 when in complex with two histone chaperones from S. cerevisaie, Nap1 and Vps75. Within the nucleosome H3 and …
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Structural investigation of teleost immunoglobulin M tetramer assembly and engineering of chimeric antibodies consisting of teleost motifs
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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The stereoselective synthesis of a novel aromatic peptide nucleic acid (APNA) oligomer
… aromatic peptide nucleic acids (APNA). The APNA tetramer 70 was prepared from the amino acid monomer (S)-50 using classical peptide synthesis. Chemical shift differences between the $\sp1$H NMR of monomer (S)-57 and tetramer 70 were observed which suggested that base stacking interactions in the …
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Hydrogen bonded cavity and polymeric nanotubular assemblies from small bicyclic monomers /
… tubular assemblies are held by orthogonal inter-tetramer H-bonding interface, established after tautoleptic aggregation into tetrameric rings. Bis-ureidopyrimidinone monomers were synthesized and their aggregation in solution investigated. Short organic nanotube composed of eight identical …
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Cisplatin-induced nucleosome and RNA polymerase II modification mediate cellular response to the drug
… of chromatin, is composed of a histone (H3/H4)₂ tetramer flanked by two H2A/H2B dimers, around which is wrapped 146 base pairs (bp) of DNA. The (H3/H4)₂ tetramer plays a central role in the structural integrity and positioning of the nucleosome core particle. Site- specifically platinated …
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Characterization of effect of tryptophan ontrp repressor subunit association using fluorescence spectroscopy
… others suggested that trp repressor exists as tetramer and higher order oligomeric forms, as well as the active dimer. Thus, the main objective of this research was to characterize the effect of tryptophan on the association of trp repressor subunits in order to determine whether the equilibria …
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Supramolekulinių vamzdelinių struktūrų sintezė biciklo[3.3.1]nonano pagrindu /
… unit, forms very stable hydrogen bonded tetramers via self-complementariness of its two tautomeric forms. The new term, tautoleptic aggregation, is introduced for describing this type of aggregation. The supramolecular tetramer undergoes reversible stacking in non-polar solvents resulting …
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Identification and characterisation of HLA-DRB1*0101 restricted CD4+ T cell epitopes in the major grass pollen allergens Phl p 1 and Phl p 5
… of epitope mapping: in silico prediction, tetramer guided epitope mapping and human HLA-DR1 transgenics. I investigated recognition of HLA-DR1-restricted CD4+ T cell epitopes in allergic and non-allergic individuals and characterised epitope-specific CD4+ T cells, according to cell surface …
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Glycan characterizations with application in metal ion binding, the 1918 influenza virus neuraminidase formation and human receptors
… of the 1918 influenza virus (H1N1) has active (tetramer) and inactive forms (monomer/dimer) with difference residing in their N-glycosylations. A structural analysis was carried out on the released N-glycans from both tetramer and dimer forms. Significant amounts of fucosylated N-linked …
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Characterization of a platinum-substituted keggin anion and studies of robust, hydrogen-bonded polyanion aggregates
… salt as [n-C4H9)4N]4SiPtW11O40H2. The tetrameric platinomolybdate [(PtMo6O24)4H21(H5O2)2][(n-C4H9)4N]9 (H2TET TBA9) was prepared from the reaction of K2Pt(OH)6 with K2MoO4 and acidification of the reaction solution to pH 2.32 with HNO3. A single-crystal X-Ray diffraction study showed …
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Folding-Driven Synthesis of Dynamic Covalent Oligomers Joined by Imine Linkages
… longer half-life compared with the imine tetramer. The folding process could affect either the protonation or attack of water in the hydrolysis mechanism. Similar trends were observed for imine reduction experiments.
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Crystal Structures of Helical Columnar pi-Conjugated Systems and Biodegradable Polyester
… is based on four-molecule repeat units (tetramers). There are 24 molecules and two turns in a 45.51 Å period of the distorted 6-fold helix. The tetramer is comprised of 2 dimers (two boat-shaped molecules placed side-by-side) facing each other in the tetramer. The rotation angle between …
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Crystallographic studies of the metal-responsive transcription factor NikR
… quaternary arrangement of the functional NikR tetramer, consisting of two dimeric Ribbon-Helix-Helix (RHH) DNA-binding domains separated by a tetrameric regulatory domain that binds metal ions (MBD). NikR is the only known metal- responsive member of the RHH family of transcription factors, and …
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Identification of rat NKT cells and molecular analysis of their surface receptor mediated activation
… und konnten mittels a-GalCer beladenen Maus-CD1d Tetramer visualisiert werden. Wie in der Maus wurden in der Ratte NKRP1A+TZR+ Zellen vorwiegend in der Leber gefunden, waren aber fünfmal weniger häufig. F344 Ratten NKT Zellen waren darüber hinaus im Gegensatz zu den CD4+ oder CD4-CD8- Maus NKT …
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A novel model system for the study of anti-tumour T-cell memory
… ß-gaI<sup>876-884</sup> peptide/MHC class I tetramer stainings identified the bone marrow as the major compartment for the long-term persistence of memory T-cells, as ß-gaI<sup>876-884</sup> specific T -cells occurred at elevated frequencies in this microenvironment as compared to the spleen …
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Studies on the Proteolytic Activation of the Membrane Enzyme, Pyruvate Oxidase
… from Escherichia coli. The enzyme is a tetramer of four apparently identical subunits with a molecular weight of 60,000 each. Amino acid analysis reveals that only 46% of the amino acid residues are hydrophobic. The specific activity of the enzyme is enhanced about 25-fold when assayed …
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Computer Methods for Investigating Hydrogen-Bonded Equilibria in Alcohols
… closed cyclic and open chain dimers, trimers and tetramers. Ab initio calculations were carried out on these components using six basis sets up to the restricted Hartree Fock 6-31 l++G(3df,3pd) level. Relevant calculated infrared wavenumber and intensity values, O-H...O bond lengths and hydrogen …
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Development of an αᵥβ₆-Binding Peptide for In Vivo Applications: Modulation of Serum Stability and Biodistribution
… of renal accumulation). The N-termini of tetrameric H2009.1 peptide were capped by acetylation or by unnatural amino acids. This capping significantly increased the half-life of H2009.1 tetramer in human serum. In vivo near-infrared fluorescence (NIRF) imaging shows that N-terminal capping …
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The Interactions for the RBP Receptor, Stimulated by Retinoic Acid Gene 6
… characterised. STRA6-ICL3 was found to form a tetramer. The native Im7 is monomeric; therefore, the domain conferred tetrameric behaviour. These data suggest that native STRA6 is likely to occur as a tetramer and that at least some of the oligomerization sites are located on this large …
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Oligomers of beta-L-arabinosides of hydroxyproline : synthesis of the carbohydrate epitope of the Art v 1 allergen
… Boc-([â-L-Araf]Hyp)3-OAll, in 35% yield. The tetramer, Boc-([â-L-Araf]Hyp)4-OAll was produced using a [2+2] strategy in 49% yield. We’ve installed terminal amides on the oligomers to best mimic the extended peptide found in the natural allergen. Production of oligomer-specific building blocks …
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