Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"tetrahydroquinoline"”.
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Synthesis of the Natural Alkaloids Angustureine, Cuspareine, Galipeine, Galipinine using α-Aminocycloalkyl Copper Reagents
<p> Tetrahydroquinolines (THQs) are a group of N-heterocyclic molecules derived from natural sources. They show a wide range of interesting biological activity and have been the basis for a variety of different medications including antibacterial and antiparasitic drugs. The Hancock alkaloids, …
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Investigation of bioactive scaffolds as antimicrobials
… for this compound class. These were the tetrahydroquinoline and N-methyl tetrahydroquinoline variants, which have not been synthesised before. The identification of these gives an opportunity further to explore the potential antimicrobial activity of ascididemin derivatives.
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Synthese neuer QUINAPHOS-Derivate und deren Einsatz in der asymmetrischen Katalyse
… in 2-position of the 1,2-dihydro- and 1,2,3,4-tetrahydroquinoline backbone, respectively, the suitable diastereomers for the asymmetric hydrogenation of functionalised olefins could be separated from the crude products in 55-62% yield. These isolated diastereomers were characterised by means of …
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Sorption of organic compounds on oil shale materials and sorption of selected chemicals on a Western soil
… organic compounds (2-Hydroxynaphthalene, 1,2,3,4-Tetrahydroquinoline, and 2,3,5-Trimethylphenol) was evaluated by batch and column sorption studies. In addition, the sorption capacity of the western soil for selected inorganic agents (arsenic, cadmium, calcium, potassium, iron, ammonium, fluoride, …
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Modular Methods for the Synthesis of α-Tertiary and α-Branched Alkylamines via Visible-Light-Mediated Radical Generation
… unique spirocyclic tetrahydronaphthyridine and tetrahydroquinoline scaffolds. Mechanistic studies inform the proposal of a redox-neutral catalytic cycle involving generation of a key α-amino radical. In the second method, α-branched amines are prepared from alkyl primary amines, alkyl aldehydes …
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Synthetic strategies for potential trypanocides
… P2 motif was attached to a trypanocidal tetrahydroquinoline (THQ) protein farnesyl transferase (PFT) inhibitor, with limited success. The P2 strategy was also applied to a non-selective, trypanocidal, quinol moiety. The quinol moiety was attached to diaminotriazine and benzamidine P2 …
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Medicinal nitro compounds
… photolysis of 1-(o-nitrobenzoyl)-1,2,3,4-tetrahydroquinoline and only Q-nitrosobenzoic acid was characterised. A mechanism to account for the formation of the aforementioned products is included in Chapter III.The N-oxidation of the hypnotic drug methaqualone has been examined (Chapter …
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Assessment of coal liquefaction behavior through product characterization with hyphenated chromatographic/spectroscopic methods
… Runs performed at Kerr McGee examined the use of tetrahydroquinoline (TBQ) as a process solvent with a Wyoming coal. Liquefaction activities were assessed through determinations of coal conversion to both solvent-soluble products and distillate yields. Per the in-house liquefaction studies, a …
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Studies on extensions of tert-amino effect: Ring-fusion to bridged biaryls and steroids
… 2 reactions, an ortho-vinyl tert-aniline gives a tetrahydroquinoline via C-C bond formation between the beta-vinyl carbon and the alfa-methylene carbon of the amino group; the reaction could be extended to heterocyclic and bi- and tri-aryl analogues of anilines to obtain novel medium or larger …
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… structure-activity relationships (SAR) of the tetrahydroquinoline scaffold of JW-2-107, including screening the new JW-2-107 analogs against a panel of human cancer cell lines including three p53WT cell lines and one p53 mutant cell line. Among the thirty-one newly synthesized JW-2-107 analogs, …
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New methodologies and approaches to reaction discovery in transition metal catalysis
… including carbazole, phenothiazines, and tetrahydroquinoline. The utility of this methodology is highlighted by the one-pot synthesis of a member of the pyrrolophenanthridone class of alkaloid natural products. In another set of studies, a new approach to the use of high-throughput, …