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Showing 1 to 7 of 7 for “"tetrahydroisoquinolines"”.
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Enhancing the cooperative binding properties of1,1'-bis(1,2,3,4-tetrahydroisoquinolines)
The design of partially reduced 1,1'-bisisoquinoline derivatives was investigated with the aim of controlling the conformation about the C1-C1' axis. This would produce ligands with unusual but predictable ligand binding properties, particularly cooperativity. The introduction of ω-aminoalkyl, …
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Studies in the stereoselective synthesis of 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines
… synthesis of 1, 1-disubstituted 1,2,3,4- tetrahydroisoquinolines using Reissert compound chemistry containing chiral acyl auxiliaries was studied with the ultimate goal of synthesizing spirobenzylisoquinoline alkaloids.
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Effects of Smoking and Gender on Tetrahydroisoquinolines and Beta-Carbolines in a Healthy Population and During Alcohol Detoxification
… evaluate the effects of smoking and gender on 1) tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) in a population of healthy subjects and 2) TIQs in an alcohol-dependent population undergoing in-patient detoxification. Comparison in plasma TIQs between the populations was additionally …
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Mechanistic Investigations and Synthetic Development of (-)-Sparteine Mediated Asymmetric Benzylic Lithiation-Substitution Reactions of Secondary Amides
… the synthesis of 1,4-disubstituted dihydro- and tetrahydroisoquinolines. Variation of either substituent is convenient as the 4-position substituent is determined by choice of the electrophile in the lithiation-substitution and the 1-position substituent is introduced prior to cyclization.
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Carbon-nitrogen bond-forming reactions in supercritical and expanded-liquid carbon dioxide media : green synthetic chemistry with multiscale reaction and phase behavior modeling
… nitrogen heterocycles known as tetrahydroisoquinolines and tetrahyrdo-carbolines. Our method involved (1) the in situ carbamation of amines from their reaction with carbon dioxide and a dialkyl carbonate and (2) the Pictet-Spengler cyclization of these carbamates by their …
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Aplicaciones sintéticas de hidrolasas y oxidorreductasas para la preparación de compuestos orgánicos ópticamente activos. Desarrollo de procesos de resolución y asimetrización enzimáticos
… and 3-methyl-1,2,3,4-tetrahydroisoquinolines via chemoenzymatic asymmetric transformations¿. Catal. Sci. Technol. 2012, 2, 1590-1595. Finalmente, en el sexto capítulo se estudia la preparación de 4-alquil-3-metil-3,4-dihidroisocumarinas mediante un proceso ¿one-pot¿ de …
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Tetrahydroisoquinoline Neurotoxins in Parkinson Disease
<p>The goal of this dissertation work was to (1) determine the distribution of several tetrahydroisoquinoline (TIQ) derivatives in rodent, normal human and Parkinson disease (PD) brain, (2) quantify the levels of these TIQ derivatives in common food sources in an effort to link specific food intake …