Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"tetherin"”.
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Mechanism and Evolutionary Origins of HIV-1 Virion Entrapment by Tetherin
<p>The cellular restriction factor, tetherin, prevents HIV-1 and other enveloped virus particles from being disseminated into the extracellular milieu by infiltrating their envelopes and by physically crosslinking them to the cell surface. However, the mechanisms underlying virion retention have …
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Paleovirological Analyses of Endogenous Retroviruses and Host Innate Immune Effectors
… we investigated the origins and evolution of tetherin, an orphan antiviral protein with no known homologs. We found that tetherin function is encoded by genes that exhibit no sequence homology and share only a common architecture and location in modern jawed vertebrate genomes, indicating an …
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Analysis of factors that affect pseudotyping in retroviruses
… it down-modulates native targets, CD4 and BST-2/tetherin. We take advantage of a novel CRISPR-Cas9 technique to present here that [beta]TrCP is a necessary host factor for Vpu to target GaLV Env, CD4, and BST-2/tetherin. The role and structure of Env cytoplasmic tails are largely unknown among …
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The Tansmembrane Associations of HIV-1 Vpu and its Human Targets
… and PVR receptors and the restriction factor tetherin, downregulation occurs through direct interaction of the proteins’ transmembrane (TM) domains. The mechanism through which a single TM domain can interact with a wide range of targets that share no obvious interaction motifs is poorly …
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VIRUS-HOST INTERACTIONS AND THE IMPACT ON HOST CELLULAR MECHANISMS
… in counteracting the interferon-stimulated gene tetherin. This study applied various molecular techniques with the aim of deciphering the interactions between pathogen and host and thereby unraveling how NiV strategically evades certain antiviral functions. Second, proteomic analyses revealed …
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Role of viral vectors in candidate HIV vaccine-induced immune responses
… of HIV restriction genes, particularly TRIM5 and tetherin. Taken together, our findings reveal a previously unappreciated role for vector-induced immune responses in HIV vaccination and provide new insights for rationale design of candidate HIV vaccines.
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Proteomic Investigation of Interferon Alpha Stimulation and Viral Regulation to Identify Candidate Antiviral Restriction Factors
… I molecules and the known restriction factor Tetherin, to be consistently upregulated by IFN at the cell surface in all donors for both cell types. Additional proteomic screens investigated the effects of vaccinia virus (VACV) infection, quantifying ~9000 human proteins over a single …