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Showing 1 to 20 of 235 for “"testis"”.
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Defining Tumorigenic Contributions of Meiotic Cancer-Testis Antigens
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Examining the Regulation and Function of Cancer Testis Antigens
Cancer Testis Antigens (CTAs) are a class of genes whose expression is generally restricted to the testis, but are reactivated in cancer cells. The function and regulation of many CTAs are unknown, however several CTAs have been shown to impact tumor cell fitness and correlate with poor prognosis. …
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Analysis of Meiotic Cancer Testis Antigens and Their Contribution to Tumorigenesis
Tumors frequently activate the expression of genes that are only otherwise required for meiosis. These Cancer Testes Antigens (CTAs) have been found to play critical roles in multiple cellular processes when aberrantly expressed in cancer. Here I found that the CTAs SPO11, GAGE and HORMAD1 play …
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Equilibrative Nucleoside Transporter Mediated Drug Disposition Across the Blood-Testis Barrier
The blood-testis barrier (BTB) protects developing germ cells by limiting entry of toxicants. This protective barrier poses a problem for therapeutic disposition to the male genital tract, which may allow viruses or cancer to persist in the testis, and impedes the development of male contraceptives …
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The Effect of Temperature on The Metabolic Activity of Rabbit Testis
Made available in DSpace on 2014-12-05T23:08:01Z (GMT). No. of bitstreams: 1 6303237.pdf: 3132514 bytes, checksum: f56dc4dc63fa46d99d248683f5304151 (MD5) Previous issue date: 1962
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REDOX HOMEOSTASIS IN THE DROSOPHILA TESTIS STEM CELL SELF-RENEWAL AND MAINTENANCE
… stem cell behaviour, using the Drosophila testis germline stem cell (GSC) model. High ROS resulted in the activation of EGFR signaling, which functions to promote GSC differentiation, leading to a GSC loss. By contrast, low ROS caused an over-growth of GSC-like cells. To understand the …
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A Histological Study of Temperature Effects on the Testis of the Fowl
Made available in DSpace on 2014-12-04T22:45:55Z (GMT). No. of bitstreams: 1 0013579.pdf: 4633387 bytes, checksum: 4237a1651c3fa9b7ace5542c65e97d7c (MD5) Previous issue date: 1955
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Determination of the glycosylation requirements for active human testis angiotensin-converting enzyme
Bibliography: leaves 90-98.
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Apical Testis Structure and the Effects of Cadmium Treatment on Spermatogenesis in Drosophila
… related species to study the structure of the testis stem cell niche, as well as other aspects of spermatogenesis. We previously revealed a novel stem cell niche structure in <em>D. pseudoobscura</em>, a distant relative of <em>D. melanogaster.</em> The signaling center of the <em>D. …
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The activin a pathway in fetal testis development and dysgenesis in the mouse
… however, the role of Inhba/activin A during testis morphogenesis is unknown. To investigate whether Inhba is required for testis development in the mouse, I analyzed fetal testis morphogenesis in Inhba-/- mice. In the absence of Inhba expression, I observed significant reductions in Sertoli …
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Palindromes on the human X chromosome : testis-biased transcription, gene conversion and evolution
… studies of the Y chromosome revealed massive, testis-specific palindromes that span 30% of the chromosome and are subject to gene conversion. We conducted studies to determine whether similar palindromes exist on the human X chromosome and, if they exist, to what degree they share the features …
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Peptides of the growth hormone-releasing hormone family: expression, localization, and functions in testis
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Correlative Analysis of Sperm Morphology, Seminiferous Epithelial Area and Testis Weight in the Boar
… taken by digitizing 50 seminiferous tubules per testis. Also, different degrees of histologic changes were determined for each testis from the same tissue sections. Testicular spermiostasis was examined macro and microscopically. Chicago, Illinois was the focal point of measuring temperature …
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Investigation of the cancer testis antigen lactate dehydrogenase C as a CD8 T cell target
… design. In our cohort of HGSC cases, the cancer testis (CT) antigen lactate dehydrogenase C (LDHC) is expressed in 76% of tumours (22/29). As LDHC presents with tumour specificity in women, I hypothesize that LDHC is an immunogenic target in HGSC patients, and that LDHC-specific T cells can be …
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