Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"testicular dysgenesis"”.
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Reproductive health effects due to pesticide exposure amongst boys in the rural Western Cape, South Africa
… fertility. Cryptorchidism, hypospadias, testicular cancer and poor sperm quality (testicular dysgenesis syndrome) have also been reported to be associated with these endocrine-disrupting chemicals. This study therefore aims to investigate the adverse reproductive health effects of …
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Role of androgens in testicular development and dysgenesis
… hypospadias) or in young adulthood (testicular germ cell cancer and low sperm counts), are common and may be increasing in incidence. These disorders have a common fetal origin and share risk factors; consequently they are hypothesized to comprise a testicular dysgenesis syndrome …
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BMP Signaling Regulates Germ Cell Pluripotency, Sexual Differentiation, and Cancer Susceptibility
Testicular germ cell tumors are the most common malignancy found in young men between the ages of 14-40. While these tumors are highly curable with cisplatin based combined chemotherapies, the treatments come with very detrimental side effects and ultimately fail in up to 15% of patients. These …
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The impact of genetic, environmental and life-style factors on male reproductive function
… than in Denmark. In parallel, the incidence of testicular cancer (TC) and of congenital malformations of male genital organs is significantly higher in Denmark as compared to Finland. Previous studies have shown an association between decreased sperm quality and risk of TC. Recently, it was …
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The activin a pathway in fetal testis development and dysgenesis in the mouse
… epithelium recapitulated the fetal testis cord dysgenesis present in Inhba-/- mice, indicating the Sertoli cells are likely the direct targets of activin A signaling. I have thus identified a novel mesenchymal-epithelial crosstalk in the developing testes wherein interstitial fetal Leydig cells …