Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 54 for “"tertiary amine"”.
-
Reductive metabolism of aliphatic tertiary amine n-oxides.
… concerning the feasibility of using aliphatic tertiary amine N-oxides as antiarrhythmic agent prodrugs. Lignocaine was selected as a candidate for prodrug development, because the N-oxide is a non-active, polar derivative of lignocaine and the drug of choice for ventricular arrhythmia, a …
-
Metal Complexes of Fourteen-Membered Macrocyclic Ligands Containing Tertiary Amine Donors
Made available in DSpace on 2014-12-13T20:09:48Z (GMT). No. of bitstreams: 1 7607004.pdf: 6033610 bytes, checksum: e74be4a28edcc1a186ddfcbb3f73c9dd (MD5) Previous issue date: 1975
-
Visible-light-mediated synthetic strategies for the synthesis of α-tertiary amine derivatives
The α-tertiary amine—a nitrogen atom with an α-carbon bearing three C–C bonds—is a motif that is widely prevalent in pharmaceutical materials and natural products. As a result of the fully substituted α-centre, compounds bearing this fragment have a high degree of structural complexity. This …
-
The photoredox-catalysed generation and reaction of alkyl α-amino radicals for α-tertiary amine synthesis
… focused on the synthesis of α-trialkyl-α-tertiary amines, exploiting photo-reductively generated alkyl α-amino radicals as intermediates. The first project describes the development of a multicomponent method for the photoredox-mediated synthesis of α-trialkyl α-tertiary amines (ATAs). …
-
New methodology for the synthesis of chiral, non-racemic a-tertiary amine centres: application to the synthesis of the marine alkaloid lepadiformine
… quaternary carbon bearing an α-nitrogen (an α-tertiary amine or ATA) continues to be an active area of modern research in current synthetic organic chemistry. As a privileged biological scaffold, ATAs are widespread amongst bioactive natural products, providing an inspiration in their complex …
-
Fabrication, analysis, application, and characterization of core-containing microparticles and hydrophilic microfluidic devices produced via the primary- and in situ tertiary-amine catalyzed Michael addition of multifunctional thiols to multifunctional acrylates
The objective of this research was to investigate amine-catalyzed thiol-acrylate chemistry for various novel applications that could fully utilize the untapped potential of this useful and robust chemistry. The use of this chemistry in each application solved a problem, improved on a disadvantage …
-
Development of new dendritic ligands for copper mediated Atom Transfer Radical Polymerization (ATRP) of methyl methacrylate
… functionalized dendrimers. Analogous secondary amine functionalized dendrimers were also synthesized by reducing the abovementioned imine functionalized dendrimers using sodium borohydride. The ligands produced were characterized by 13C / 1H NMR, and infra-red spectroscopy as well as elemental …
-
Chelated fluoroboron cations : synthesis and multinuclear nmr studies
… (DD)BF2+, where DD is a saturated polydentate tertiary-amine or polydentate aromatic ligand, has been systematically studied by using multinuclear solution and solid state nuclear magnetic resonance spectroscopy and fast atom bombardment mass spectrometry. Three new methods of synthesis of …
-
The Photochemistry of 3- and 4-Nitro Phenyl Azides
… azides in inert and reactive solvents was examined. Photolysis of nitrophenyl azides in solution at room temperature or in a frozen glass at 77 K gives triplet nitrenes. The products of the reaction of triplet nitrenes depend on the power of the light source. Triplet 4-nitrophenyl nitrene …
-
Approaches to the synthesis of diazabiphenylenes
… two dilactams were reduced to the corresponding amines cis,trans,cis-4,10-diazatricyclo[6,4,0,0 2,7]-dodecane and cis,trans,cis-3,9-diazatricyclo[6,4,0,0 2,7]-dodecane, with diborane, the structures of which were established on the basis of their spectroscopic properties and also those of their …
-
Synthesis and Characterization of Zwitterion-Containing Acrylic (Block) Copolymers for Emerging Electroactive and Biomedical Applications
… 2-(Dimethylamino)ethyl acrylate (DMAEA), a tertiary amine-containing acrylic monomer, exhibited radical chain transfer tendency toward itself, which is undesirable in controlled radical polymerization processes. We employed a higher [RAFT] : [Initiator] ratio of 20 : 1 to minimize the impact …
-
New axially chiral amine organocatalysts
… is reported for the synthesis and use of tertiary amine organocatalysts based on the now ubiquitous binaphthyl backbone. The tertiary amines synthesized were shown to be effective nitrogen transfer reagents in the asymmetric aziridination of chalcone substrates, with enantiomeric excesses …
-
Palladium(II)-Catalysed sp 3 C–H Functionalisation of Hindered Amines and its Application in Synthesis of Astemizole Analogues
… C–H carbonylation of hindered secondary amines is described. Central to this strategy is the temporary conversion of simple ketones into hindered secondary amines that facilitates a sterically promoted palladium-catalysed C–H activation. A range of functional groups are shown to be …
-
Asymmetric synthesis of amines by the catalytic enantioselective additions of hydrazoic acid to ketenes
… to hindered ketenes, en route to enantioenriched amines. The addition of HN3 to a ketene is likely occurring by the Bronsted acid catalysis mechanism. The evidence in support of the Bronsted acid catalysis mechanism include stereochemical and spectroscopic results, which are consistent with data …
-
Electro-catalytic reactions
… electrocatalytic ECL reaction of Ru(bpy)32+ with tertiary amines in particular with codeine as a model compound was investigated. The aim of the work was to develop a portable drug testing device, that gave good sensitivity and reproducibility. The Ru(bpy)32+ was immobilized within the sol-gel …
-
Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles
… and 75 were targeted to elucidate the effects of tertiary amine functionalization on gene delivery efficacy. Means of characterization included gel permeation chromatography (GPC), dynamic light scattering (DLS), electrophoresis, and in vitro gene expression and toxicity studies. As a result from …
-
Transfer of alkyl groups in novel amidine dications and other superelectrophiles
… analogue XVII with phenyl residues on the tertiary amine allowed for isolation and characterisation of amidinium dication XVIII. The reaction protocol was subsequently applied to derivatives of 2-(alkylthio)phenylformamides XIX which underwent alkyl transfer to yield benzothiazolium salt …
-
Applications of Molecular Switching and Logic
… fluorophore and an aliphatic tertiary amine as the H+ receptor where necessary. The H+-induced fluorescence enhancement factors are signatures which identify a given bead type within a mixed population when examined with a fluorescence microscope. Therefore, molecular …
-
Studies on the oxidative degradation of fluphenazine decanoate in oily solution
… demonstrated to catalyse oxidation of the tertiary amine centres in the molecule, a finding contrary to reports in the literature. In addition, the catalytic effect was shown to be related to the pKa value of the acid. Benzyl alcohol is commonly added as a preservative to oily formulations …
Page 1 of 3