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Showing 1 to 20 of 32 for “"terpenoid"”.
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Evaluation of camphor derivatives in terpenoid synthesis
… two compounds were evaluated as intermediates in terpenoid synthesis. Addition of an alkenyl unit to (+)-5,6-dehydro-camphor (36) and subsequent anionic oxy-Cope rearrangement of the resulting 1,5-diene (64) provided hydrindenone 66. Ring expansion of 66 provided decalin intermediate 69 which …
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The Synthetic Biology of N2-Fixing Cyanobacteria for Photosynthetic Terpenoid Production
… biofuels, which are secreted from their cells. Terpenoids constitute one of the largest classes of organic molecules on Earth, and are attractive candidates as a fourth generation biofuel and industrial chemical. In cyanobacteria, the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is …
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Identification, Characterization, and Functional Analysis of Terpenoid Specialized Metabolism in Switchgrass (Panicum virgatum) and Carrot (Daucus carota)
Plants produce a large number of specialized or secondary compounds that aid in their reproduction and protection against biotic and abiotic stress. In this work I investigated the metabolism and function of terpenes, the largest class of specialized metabolites, in switchgrass and carrot. …
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Terpenoid metabolites from three dorid nudibranchs and a new bromotryptamine derivative from the Northeast Pacific sponge Plocamissa igzo
Investigation of the terpenoid metabolites present in the extracts of three dorid nudibranchs has led to the isolation of sixteen known and ten new compounds. Structures were determined through extensive spectroscopic analysis. In addition, a new bromotryptamine derived compound was isolated from …
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Control of Substrate Supply to the Chloroplast 2-C-methyl-D-erythritol-4-phosphate Pathway
… (MEP) pathway supplies precursors for plastidic terpenoid biosynthesis, making it a focal point for manipulating terpenoid production in plants. The MEP pathway generates the universal terpenoid intermediates isopentenyl and dimethylallyl diphosphate (IDP and DMADP) from central carbon …
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Time Dependent Uptake of Volatile Organic Compounds on Silica and the Observation and Quantification of Ambient Sesquiterpenes in Virginia
… substituted benzene derivatives and several terpenoid compounds for a silica surface composed of hydroxyl groups and bridging oxygen species. Results for benzene derivatives show an enhancement of the initial γ value of all functionalized compounds relative to benzene, with this initial value …
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DEVELOPING MOLECULAR TOOLS TO IMPROVE TERPENOIDS PRODUCTION IN RHODOSPORIDIUM TORULODIES
Terpenoids produced are usually highly toxic to the host cells, leading to early shut-off of the biosynthesis. Red yeasts, particularly species in Rhodosporidium, were considered high-yielding platform for terpenoids production due to their remarkable potentials for lipid production and their …
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Gene expression and biochemistry of isoprenoid biosynthesis in the glandular secretory trichomes of Artemisia annua
… (BLAST) results suggested a possible function in terpenoid metabolism were investigated by RT-PCR. Known terpenoid biosynthetic enzymes, such as amorpha-4,11-diene synthase showed a high degree of trichome-specific expression. In order to investigate cell specific gene expression within the …
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From Forest Floors to Pharmacology: Elucidating Millipede Defensive Alkaloids for Drug Discovery
… behavior, brood care, and the production of terpenoid alkaloids. Prior to 2020, only 11 alkaloids were known. Herein, a total of 25 new terpenoid alkaloids are reported coming from three different genera, all belonging to the same order. Key findings include the discovery of indolizine and …
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Optimizing nuclear transgene expression and genome editing for high-value compound production in the green microalga Chlamydomonas reinhardtii
… production of valuable compounds like terpenoids is essential to overcome low production in their native hosts and to avoid harsh extraction methods, which produce large amounts of toxic waste. Various organisms were genetically engineered to express various terpene synthases, however, …
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Structure, Function and Applications of Metal-Requiring Enzymes: Carbonic Anhydrase and Epi-Isozizaene Synthase
… substrate binding and catalysis in a bacterial terpenoid cyclase, and enables a comparison of substrate recognition amongst terpenoid synthases from different domains of life. Mutagenesis of aromatic residues in the enzyme active site alters the cyclization template and results in the production …
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On the bicyclic acids of petroleum
… several fused bicyclic acids, as well as some terpenoid-derived drimane and labdane acids. However, identifications were limited somewhat by a lack of reference mass spectra and lack of availability of reference compounds for co-chromatography. A complementary method, based on an historical …
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Isolation and Partial Characterization of the Toxic Substance from EREMOCARPUS SETIGERUS BENTH
… the toxic substance gave a positive terpene-terpenoid test. This leads us to believe that the toxic substance might belong to the triterpenoid series.</p>
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Metabolic engineering for the production of functionalized terpenoids in heterologous hosts
Terpenoids are a large and diverse group of secondary metabolites which natively play essential biochemical roles, and have been adopted for a wide range of uses by humans. These molecules are of interest scientifically due to their often complex structures, as well as commercially, with market …
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Isolation and Structure Elucidation of Antiproliferative and Antiplasmodial Natural Products from Plants
… fractionation, two known antiproliferative terpenoids (2.1 and 2.2) were isolated from Hypoestes sp. (Acanthaceae), four known antiplasmodial liminoids (3.1-3.4) were isolated from Carapa guianensis (Meliaceae), one inactive terpenoid (4.1) was isolated from Erica maesta (Ericaceae), and …
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Phytochemical and toxocological studies of some Botswanan plants used in traditional medicine
… from the plants. A. brevifolia yielded terpenoids, phenolics, phenolic glycosides, a component of procyanidins, a lignan glycoside and sugars. E. axillare yielded terpenoids, a secoiridoid, and sugars, whereas A. mexicana yielded alkaloids. Investigation of C. italica and J. erythropoda …
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Mechanistic investigations on polyprenyl transferases and multi-target antibiotic discovery
Terpenoid biosynthesis plays essential structural and functional roles in almost all life forms. Prenyl transferases, enzymes involved in the isoprenoid metabolism related to prenyl chains, transfer allylic prenyl groups to acceptor molecules. Head-to-tail condensations, usually of allylic …
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The final masquerade: a molecular-based approach to the identification of resinous plant exudates in Roman mortuary contexts in Britain and evaluation of their significance
… chromatography-mass spectrometry has revealed terpenoid biomarkers in sixteen inhumation and two cremation burials. The natural products characterized include European Pinaceae (conifer) resins, Pistacia spp. (mastic/terebinth) resins from the Mediterranean or the Levant and Boswellia spp. …
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An investigation into the rapidly induced chemical responses of Myrica gale to insect herbivory
… a second set sustained capsid bug herbivory. The terpenoid and phenolic profile of leaves from each set was obtained on a weekly basis using GLC and IIPLC respectively. GC-MS was used to identify constituents of the volatile oil. UV, ¹H and ¹³C NMR, El-MS and FAB-tlS were used to identify the …
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